Development of novel Paullone-based PROTACs as Anticancer agents DOI

Manda Srinivas,

Vamsee Krishna Chatakonda,

Vinod G. Ugale

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141273 - 141273

Published: Dec. 1, 2024

Language: Английский

Antioxidant, and enzyme inhibition effects of chia (Salvia hispanica) seed oil: A comprehensive phytochemical screening using LC-HR/MS DOI Creative Commons

Muzaffer Mutlu,

Zeynebe Bingöl,

Eda Mehtap Özden

et al.

Electronic Journal of Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity DOI Creative Commons
Hamada H. H. Mohammed,

Sherif A. Abdel‐Fattah,

Hesham M. Hassan

et al.

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: April 4, 2025

Introduction: Carbonic anhydrase IX (CA IX) is a tumor-associated enzyme involved in cancer progression and survival. Targeting CA with selective inhibitors like SLC-0111 has shown therapeutic potential. This study aimed to develop novel 4-pyridyl analog ( Pyr ) of enhanced anticancer activity. Methods: was synthesized using tail-based design characterized by NMR. Its cytotoxicity tested against normal cell lines. inhibition, cycle effects, apoptosis induction, protein expression changes were evaluated. Molecular docking ADMET predictions assessed binding drug-like properties. Results Discussion: showed toward cells potent inhibition. It induced G0/G1 arrest, apoptosis, modulated p53, Bax, Bcl-2 levels. Docking confirmed strong binding, analysis indicated good oral bioavailability. These results support as promising candidate.

Language: Английский

Citations

0
Some Novel Oxirane-Thiirane Derivatives: Synthesis, Molecular docking and Enzymatic Inhibition for Therapeutic Potential DOI
Vagif Farzaliyev, Adem Ertürk,

A.T. Huseynova

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Language: Английский

Citations

0
Computer aided design of CGA-N9 derived peptides based on oligopeptide transporters and their antifungal evaluations DOI
Yan Fu, Yiqing Sun, Shaojie Zhang

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 160, P. 108485 - 108485

Published: April 17, 2025

Language: Английский

Citations

0
Comprehensive Insights into Carbonic Anhydrase Inhibition: A Triad of In vitro, In silico, and In vivo Perspectives DOI
Ahmed A. Allam, Hassan A. Rudayni, Noha Ahmed

et al.

Enzyme and Microbial Technology, Journal Year: 2025, Volume and Issue: 189, P. 110657 - 110657

Published: April 17, 2025

Language: Английский

Citations

0
Development of novel Paullone-based PROTACs as Anticancer agents DOI

Manda Srinivas,

Vamsee Krishna Chatakonda,

Vinod G. Ugale

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141273 - 141273

Published: Dec. 1, 2024

Language: Английский

Citations

0