Copper and metformin double-doped polydopamine nanoparticles for tumor photothermal therapy DOI Creative Commons
Yunfeng Luo, Wenkai Zhang,

Muge Gu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 16, 2024

Abstract The anti-tumor potentials of copper and metformin have been wildly studied. Excessive intracellular could lead cancer cells to cuproptosis, while activate adenosine monophosphate-activated protein kinase (AMPK) decrease ATP generate reactive oxygen species (ROS). This study integrated ably form a polydopamine nanoparticle (CMP NPs) through coordination bonds. CMP NPs showed high photothermal efficiency efficacy both in vitro vivo experiments. effective therapy (PTT) not only inhibited the growth primary tumors but also generated an in-situ tumor vaccine-like function by immunogenic cell death restrain regrowth secondary tumors, showing promising PTT for malignant solid tumors.

Язык: Английский

Biomolecule-based engineered nanoparticles for Cancer Theranostics DOI

Narayanan Parthasarathy,

Ramar Thangam, Babu Rithisa

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 530, С. 216489 - 216489

Опубликована: Фев. 3, 2025

Язык: Английский

Процитировано

1
Recent research progress on metal ions and metal-based nanomaterials in tumor therapy DOI Creative Commons

Yongcheng Xu,

Aikebaier Reheman,

Wenhua Feng

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Фев. 7, 2025

Tumors, as a disease that seriously threatens human health, have always been major challenge in the field of medicine. Currently, main methods tumor treatment include surgery, radiotherapy, chemotherapy, etc., but these traditional often certain limitations. In addition, recurrence and metastasis are also difficult problems faced clinical treatment. this context, importance metal-based nanomaterials therapy is increasingly highlighted. Metal-based possess unique physical, chemical, biological properties, providing new ideas for can achieve targeted tumors through various mechanisms, reducing damage to normal tissues; they serve drug carriers, improving stability bioavailability drugs; at same time, some photothermal, photodynamic, other characteristics, which be used phototherapy tumors. This review examines latest advances application within past 5 years, presents prospective insights into future applications.

Язык: Английский

Процитировано

0
Nano Copper‐chelate Triggers Cuproptosis‐like Death in Fungi and Synergizes with Microneedles for Enhanced Biofilm Removal DOI Open Access

Xing Ge,

Shuyue Deng,

Lei Chen

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Fungal infections pose a significant global public health threat, particularly candidemia and biofilm formation. Current antifungal drugs have limitations due to their toxicity drug resistance. Ion interference therapy, cuproptosis, shows potential for disease treatment. Herein, nano copper-chelate Cu(DDC)2@BSA (CDB) is synthesized research the mechanism of cuproptosis-like death investigated. Initially, CDB demonstrates strong inhibitory effect on multiple fungi exhibits activity against two fluconazole-resistant clinical isolates. The decrease in ATPase mitochondrial membrane indicates that may involve dysfunction. Subsequently, transcriptome analysis reveals alterations genes related copper ions transport regulation, oxidative phosphorylation, function. Additionally, overload observed, along with an increase heat shock protein 70 levels lipoic acid synthetase expression. Given biofilms hinder penetration, quaternary ammonium chitosan microneedles are employed combination penetrate barrier enhance effect. Overall, this study provides new insight into presents promising strategy fungal infection treatment through microneedle delivery system.

Язык: Английский

Процитировано

0
Strategy of “Controllable Ions Interference” for Boosting MRI-Guided Ferroptosis Therapy of Tumors DOI

Zhen Chang,

Zhiyu Liang, Lan Yu

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Chemotherapy for oral squamous cell carcinoma (OSCC) is often marred by the development of multidrug resistance and systemic adverse effects. Metal ion interference therapy (MIIT) has risen as an innovative strategy to disrupt intracellular metal equilibrium in tumor cells, potentially overcoming drug resistance. However, effectiveness cancer treatment that relies on delivering single ions site constrained. To address this, we have developed a therapeutic nanoplatform employing hollow mesoporous manganese dioxide nanoparticles (HMON) which harness chelating properties tannic acid control loading release Zn2+ Pt2+, i.e., Zn@CDDP@HMON. In acidic microenvironment, Pt2+ strategically released from can inhibit mitochondrial respiration activate NADPH oxidases (NOXs), respectively, increasing superoxide anion (O2•–) hydrogen peroxide production (H2O2). The Mn4+ consumes glutathione (GSH) generate Mn2+, reacts with H2O2 Fenton-like reaction, producing hydroxyl radicals (•OH) inducing lipid peroxidation (LPO). depletion GSH also inhibits GPX4 activity, sensitizing cells ferroptosis. Furthermore, reduced Mn2+ facilitates T1-MRI imaging, allowing real-time monitoring distribution accumulation tumors.

Язык: Английский

Процитировано

0
Spatially Targeted Triple Amplification of Oxidative Stress for Enhanced Tumor Therapy via Effective Modulation of Metal Ion Valence States DOI

Jing Yu,

Chen Wang,

Fan Zhao

и другие.

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Therapeutic application of nanosystems-based metalloptosis for enhanced tumor radiotherapy DOI

Meili Chen,

Ling Chen,

Kun Mao

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 536, С. 216666 - 216666

Опубликована: Апрель 10, 2025

Язык: Английский

Процитировано

0
Copper and metformin double-doped polydopamine nanoparticles for tumor photothermal therapy DOI Creative Commons
Yunfeng Luo, Wenkai Zhang,

Muge Gu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 16, 2024

Abstract The anti-tumor potentials of copper and metformin have been wildly studied. Excessive intracellular could lead cancer cells to cuproptosis, while activate adenosine monophosphate-activated protein kinase (AMPK) decrease ATP generate reactive oxygen species (ROS). This study integrated ably form a polydopamine nanoparticle (CMP NPs) through coordination bonds. CMP NPs showed high photothermal efficiency efficacy both in vitro vivo experiments. effective therapy (PTT) not only inhibited the growth primary tumors but also generated an in-situ tumor vaccine-like function by immunogenic cell death restrain regrowth secondary tumors, showing promising PTT for malignant solid tumors.

Язык: Английский

Процитировано

0