Copper and metformin double-doped polydopamine nanoparticles for tumor photothermal therapy DOI Creative Commons
Yunfeng Luo, Wenkai Zhang,

Muge Gu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract The anti-tumor potentials of copper and metformin have been wildly studied. Excessive intracellular could lead cancer cells to cuproptosis, while activate adenosine monophosphate-activated protein kinase (AMPK) decrease ATP generate reactive oxygen species (ROS). This study integrated ably form a polydopamine nanoparticle (CMP NPs) through coordination bonds. CMP NPs showed high photothermal efficiency efficacy both in vitro vivo experiments. effective therapy (PTT) not only inhibited the growth primary tumors but also generated an in-situ tumor vaccine-like function by immunogenic cell death restrain regrowth secondary tumors, showing promising PTT for malignant solid tumors.

Language: Английский

Biomolecule-based engineered nanoparticles for Cancer Theranostics DOI

Narayanan Parthasarathy,

Ramar Thangam, Babu Rithisa

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489

Published: Feb. 3, 2025

Language: Английский

Citations

1
Nano Copper‐chelate Triggers Cuproptosis‐like Death in Fungi and Synergizes with Microneedles for Enhanced Biofilm Removal DOI Open Access

Xing Ge,

Shuyue Deng,

Lei Chen

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Fungal infections pose a significant global public health threat, particularly candidemia and biofilm formation. Current antifungal drugs have limitations due to their toxicity drug resistance. Ion interference therapy, cuproptosis, shows potential for disease treatment. Herein, nano copper-chelate Cu(DDC)2@BSA (CDB) is synthesized research the mechanism of cuproptosis-like death investigated. Initially, CDB demonstrates strong inhibitory effect on multiple fungi exhibits activity against two fluconazole-resistant clinical isolates. The decrease in ATPase mitochondrial membrane indicates that may involve dysfunction. Subsequently, transcriptome analysis reveals alterations genes related copper ions transport regulation, oxidative phosphorylation, function. Additionally, overload observed, along with an increase heat shock protein 70 levels lipoic acid synthetase expression. Given biofilms hinder penetration, quaternary ammonium chitosan microneedles are employed combination penetrate barrier enhance effect. Overall, this study provides new insight into presents promising strategy fungal infection treatment through microneedle delivery system.

Language: Английский

Citations

0
Spatially Targeted Triple Amplification of Oxidative Stress for Enhanced Tumor Therapy via Effective Modulation of Metal Ion Valence States DOI

Jing Yu,

Chen Wang,

Fan Zhao

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Defect‐Rich MoO3‐X@CuO2 Nanosheets Mediated Ultrasound‐Enhanced Cuproptosis Antibacterial Activity and M2 Macrophage Reprogramming for Optimizing Diabetic Wound Repairment DOI
Yutang Li, Yi Wang, Yandong Wang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Abstract Diabetic wounds are often plagued by persistent bacterial infections, which exacerbate inflammation and impair healing processes such as collagen deposition fibroblast migration. Conventional antibiotic therapies frequently prove ineffective can even hinder wound repair. To address these challenges, biodegradable MoO 3‐x @CuO 2 ion disruptors (MCO IDs) that for comprehensive diabetic treatment is developed. The MCO IDs generate a burst of multimodal reactive oxygen species (ROS) effectively penetrate defenses disrupt redox homeostasis. Released copper ions induce proteotoxic stress‐like death targeting lipoylated iron–sulfur cluster proteins. Transcriptomic metabolomic analyses reveal this mechanism systematically inhibits energy metabolism gene expression, suppressing proliferation. Following eradication, the released promote macrophage repolarization to M2 phenotype, mitigating chronic stimulating healing. Furthermore, enhance management, portable dressing (PVA‐MCO) fabricated electrospinning polyvinyl alcohol (PVA) incorporating IDs. In vivo studies demonstrate PVA‐MCO eliminates pathogenic bacteria promotes deposition, angiogenesis, epithelialization, thereby accelerating This multifaceted therapeutic strategy offers promising solution managing infections promoting

Language: Английский

Citations

0
Recent research progress on metal ions and metal-based nanomaterials in tumor therapy DOI Creative Commons

Yongcheng Xu,

Aikebaier Reheman,

Wenhua Feng

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 7, 2025

Tumors, as a disease that seriously threatens human health, have always been major challenge in the field of medicine. Currently, main methods tumor treatment include surgery, radiotherapy, chemotherapy, etc., but these traditional often certain limitations. In addition, recurrence and metastasis are also difficult problems faced clinical treatment. this context, importance metal-based nanomaterials therapy is increasingly highlighted. Metal-based possess unique physical, chemical, biological properties, providing new ideas for can achieve targeted tumors through various mechanisms, reducing damage to normal tissues; they serve drug carriers, improving stability bioavailability drugs; at same time, some photothermal, photodynamic, other characteristics, which be used phototherapy tumors. This review examines latest advances application within past 5 years, presents prospective insights into future applications.

Language: Английский

Citations

0
Strategy of “Controllable Ions Interference” for Boosting MRI-Guided Ferroptosis Therapy of Tumors DOI

Zhen Chang,

Zhiyu Liang, Lan Yu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Chemotherapy for oral squamous cell carcinoma (OSCC) is often marred by the development of multidrug resistance and systemic adverse effects. Metal ion interference therapy (MIIT) has risen as an innovative strategy to disrupt intracellular metal equilibrium in tumor cells, potentially overcoming drug resistance. However, effectiveness cancer treatment that relies on delivering single ions site constrained. To address this, we have developed a therapeutic nanoplatform employing hollow mesoporous manganese dioxide nanoparticles (HMON) which harness chelating properties tannic acid control loading release Zn2+ Pt2+, i.e., Zn@CDDP@HMON. In acidic microenvironment, Pt2+ strategically released from can inhibit mitochondrial respiration activate NADPH oxidases (NOXs), respectively, increasing superoxide anion (O2•–) hydrogen peroxide production (H2O2). The Mn4+ consumes glutathione (GSH) generate Mn2+, reacts with H2O2 Fenton-like reaction, producing hydroxyl radicals (•OH) inducing lipid peroxidation (LPO). depletion GSH also inhibits GPX4 activity, sensitizing cells ferroptosis. Furthermore, reduced Mn2+ facilitates T1-MRI imaging, allowing real-time monitoring distribution accumulation tumors.

Language: Английский

Citations

0
Therapeutic application of nanosystems-based metalloptosis for enhanced tumor radiotherapy DOI

Meili Chen,

Ling Chen,

Kun Mao

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 536, P. 216666 - 216666

Published: April 10, 2025

Language: Английский

Citations

0
Targeted modulation of dual-metal ion homeostasis to induce ER stress and cuproptosis for synergistic breast tumor suppression DOI

Xiaoxian Zhang,

Xuequan Zhang, Jiahui Zhu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163248 - 163248

Published: April 1, 2025

Language: Английский

Citations

0
Copper and metformin double-doped polydopamine nanoparticles for tumor photothermal therapy DOI Creative Commons
Yunfeng Luo, Wenkai Zhang,

Muge Gu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract The anti-tumor potentials of copper and metformin have been wildly studied. Excessive intracellular could lead cancer cells to cuproptosis, while activate adenosine monophosphate-activated protein kinase (AMPK) decrease ATP generate reactive oxygen species (ROS). This study integrated ably form a polydopamine nanoparticle (CMP NPs) through coordination bonds. CMP NPs showed high photothermal efficiency efficacy both in vitro vivo experiments. effective therapy (PTT) not only inhibited the growth primary tumors but also generated an in-situ tumor vaccine-like function by immunogenic cell death restrain regrowth secondary tumors, showing promising PTT for malignant solid tumors.

Language: Английский

Citations

0