Russian Journal of Physical Chemistry A, Год журнала: 2024, Номер 98(14), С. 3342 - 3346
Опубликована: Дек. 1, 2024
Язык: Английский
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 30, 2025
Accurately diagnosing infectious diseases in a resource-limited setting is major challenge. Plasmonic materials, via localized surface plasmon resonance (LSPR), have greatly enhanced fluorescence signal and detection sensitivity. However, traditional plasmonic-enhanced methods largely rely on near-infrared or visible-light fluorophores with small Stokes shift, limiting naked-eye visibility without filters. In this study, we developed novel plasmonic silver film (pSilverF) to enhance large allowing for improved biomarker sensitivity under observation. Integrated bright fluorescent nanoparticles, designed multiplexed assay detecting Hepatitis C Virus (HCV), B (HBV), Human Immunodeficiency (HIV) antibodies, achieving sensitivities down 0.0032, 0.023, 0.168 NCU/mL, respectively. cohort of 68 clinical samples, our method achieved 100% specificity HIV HCV 96% HBV detection. Notably, the results can be visualized by naked eye directly captured standard mobile phone camera any modification analysis using RGB image splitting. This platform demonstrated potential field multiple simple settings, providing useful tool disease control communities areas limited medical resources.
Язык: Английский
Процитировано
0
Journal of Fluorescence, Год журнала: 2025, Номер unknown
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
0
The Journal of Physical Chemistry Letters, Год журнала: 2025, Номер 16(9), С. 2273 - 2282
Опубликована: Фев. 24, 2025
Modern photodynamic therapy (PDT) demands next-generation photosensitizers (PSs) that overcome heavy-atom dependency and enhance efficacy beyond traditional, highly oxygen-dependent type II mechanisms. We introduce herein TCI-NH, as a thiochromenocarbazole imide derivative designed for I action. Upon light activation, TCI-NH efficiently favors superoxide (O2•-) PS-centered radical formation instead of singlet oxygen (1O2) generation. Its high luminescence efficiency selective localization in both the endoplasmic reticulum mitochondria enable precise, image-guided PDT. Notably, interactions with biomolecules, such serum albumin or DNA, TCI-NH's emission by up to 40-fold amplify generation 5-fold. With negligible dark toxicity, this results ∼120 nM photocytotoxicity along an impressive phototherapeutic index exceeding 200. Real-time live-cell imaging revealed rapid, light-triggered cytotoxicity characterized apoptotic body extensive cellular damage. its small size, heavy-atom-free structure, exceptional, organelle specificity, therapeutic efficacy, sets new benchmark anticancer
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 18, 2025
Abstract Epoxy‐type afterglow luminescence is a cascade reaction of photochemical defects caused as result the formation and release epoxy intermediates, exhibiting continuous phenomenon that remains intrinsic after excitation, with extremely impressive signal‐to‐background ratio (SBR) level in vivo. Afterglow based on this epoxy‐type mechanism ideally suited for applications developments diagnosis treatment biological diseases. In tutorial review, work aims to deeply elaborate mechanisms materials present application imaging Lastly, future perspectives potential challenges technology preclinical diagnostic, therapeutic, predictive analyses, well clinical translations are discussed.
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(33), С. 8107 - 8121
Опубликована: Янв. 1, 2024
Schematic illustration of the twisted π-conjugated system strategy to achieve enhanced fluorescence emission and ROS generation efficiency.
Язык: Английский
Процитировано
3
Russian Journal of Physical Chemistry A, Год журнала: 2024, Номер 98(14), С. 3342 - 3346
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0