Using Graph Neural Networks to Predict Positions of the Absorption Maxima of a Number of Dyes DOI
Mikhail M. Lukanov, Alexander A. Ksenofontov

Russian Journal of Physical Chemistry A, Journal Year: 2024, Volume and Issue: 98(14), P. 3342 - 3346

Published: Dec. 1, 2024

Language: Английский

Heavy-atom-free π-twisted photosensitizers for fluorescence bioimaging and photodynamic therapy DOI Creative Commons
Darío Puchán Sánchez, Korentin Morice, Monika Mutovska

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(33), P. 8107 - 8121

Published: Jan. 1, 2024

Schematic illustration of the twisted π-conjugated system strategy to achieve enhanced fluorescence emission and ROS generation efficiency.

Language: Английский

Citations

4
The Aggregation and Disaggregation Behavior of Chain Aromatic Hydrocarbon Derivatives Modulated by pH and act as Efficient Fluorescence Quencher for Polycyclic Aromatic Hydrocarbons DOI
Weijian Xue,

Xiangyu Ling,

Huiqian Li

et al.

Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0
Organelle-Specific Thiochromenocarbazole Imide Derivative as a Heavy-Atom-Free Type I Photosensitizer for Biomolecule-Triggered Image-Guided Photodynamic Therapy DOI Creative Commons

Karolina Saczuk,

Ahmad Kassem,

Marta Dudek

et al.

The Journal of Physical Chemistry Letters, Journal Year: 2025, Volume and Issue: 16(9), P. 2273 - 2282

Published: Feb. 24, 2025

Modern photodynamic therapy (PDT) demands next-generation photosensitizers (PSs) that overcome heavy-atom dependency and enhance efficacy beyond traditional, highly oxygen-dependent type II mechanisms. We introduce herein TCI-NH, as a thiochromenocarbazole imide derivative designed for I action. Upon light activation, TCI-NH efficiently favors superoxide (O2•-) PS-centered radical formation instead of singlet oxygen (1O2) generation. Its high luminescence efficiency selective localization in both the endoplasmic reticulum mitochondria enable precise, image-guided PDT. Notably, interactions with biomolecules, such serum albumin or DNA, TCI-NH's emission by up to 40-fold amplify generation 5-fold. With negligible dark toxicity, this results ∼120 nM photocytotoxicity along an impressive phototherapeutic index exceeding 200. Real-time live-cell imaging revealed rapid, light-triggered cytotoxicity characterized apoptotic body extensive cellular damage. its small size, heavy-atom-free structure, exceptional, organelle specificity, therapeutic efficacy, sets new benchmark anticancer

Language: Английский

Citations

0
Field Detection of Multiple Infectious Diseases with Naked Eye Using Plasmonic-Enhanced Fluorescent Nanoparticles DOI
Xuan Tan,

Jingkai Yang,

Ying Liu

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Accurately diagnosing infectious diseases in a resource-limited setting is major challenge. Plasmonic materials, via localized surface plasmon resonance (LSPR), have greatly enhanced fluorescence signal and detection sensitivity. However, traditional plasmonic-enhanced methods largely rely on near-infrared or visible-light fluorophores with small Stokes shift, limiting naked-eye visibility without filters. In this study, we developed novel plasmonic silver film (pSilverF) to enhance large allowing for improved biomarker sensitivity under observation. Integrated bright fluorescent nanoparticles, designed multiplexed assay detecting Hepatitis C Virus (HCV), B (HBV), Human Immunodeficiency (HIV) antibodies, achieving sensitivities down 0.0032, 0.023, 0.168 NCU/mL, respectively. cohort of 68 clinical samples, our method achieved 100% specificity HIV HCV 96% HBV detection. Notably, the results can be visualized by naked eye directly captured standard mobile phone camera any modification analysis using RGB image splitting. This platform demonstrated potential field multiple simple settings, providing useful tool disease control communities areas limited medical resources.

Language: Английский

Citations

0
Molecular Strategies for Constructing Epoxy‐Type Afterglow Probes in Disease Diagnosis and Treatment DOI

Maocheng Zuo,

Yidan Hu,

L. Xiao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Epoxy‐type afterglow luminescence is a cascade reaction of photochemical defects caused as result the formation and release epoxy intermediates, exhibiting continuous phenomenon that remains intrinsic after excitation, with extremely impressive signal‐to‐background ratio (SBR) level in vivo. Afterglow based on this epoxy‐type mechanism ideally suited for applications developments diagnosis treatment biological diseases. In tutorial review, work aims to deeply elaborate mechanisms materials present application imaging Lastly, future perspectives potential challenges technology preclinical diagnostic, therapeutic, predictive analyses, well clinical translations are discussed.

Language: Английский

Citations

0
A DIE responsive fluorescent probe for phthalate and its application in test paper and hydrogel detection platforms DOI

Lu-Yu Li,

Zekai Li,

Jing Shu

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126403 - 126403

Published: May 1, 2025

Language: Английский

Citations

0
Using Graph Neural Networks to Predict Positions of the Absorption Maxima of a Number of Dyes DOI
Mikhail M. Lukanov, Alexander A. Ksenofontov

Russian Journal of Physical Chemistry A, Journal Year: 2024, Volume and Issue: 98(14), P. 3342 - 3346

Published: Dec. 1, 2024

Language: Английский

Citations

0