Site-selective cleavage of peptides and proteins targeting aromatic amino acid residues

RSC Advances, Journal Year: 2025, Volume and Issue: 15(12), P. 9159 - 9179

Published: Jan. 1, 2025

This review provides an account of the site-selective cleavage peptides and proteins at aromatic amino acid residues, developed over last seven decades (1958–2024).

Language: Английский

Late-Stage N-Arylation of Tryptophan-Containing Peptides and Drug Molecules via Arylthianthrenium Salts

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

We report herein a mild and efficient method for the late-stage N-arylation of tryptophan tryptophan-containing peptides using readily accessible arylthianthrenium salts through dual photoredox/copper catalysis. Applying this protocol, library noncanonical amino acids N-arylated was facilely prepared. Moreover, protocol enables peptide ligation conjugation, offering convenient access to ligated peptide/drug conjugates. Remarkably, strategy can also be applied modification complex drug molecules.

Language: Английский

Residue-Specific Protein-Glycan Conjugation Strategies for the Development of Pharmaceutically Promising Glycoconjugate Vaccines: A Recent Update

Carbohydrate Research, Journal Year: 2025, Volume and Issue: unknown, P. 109476 - 109476

Published: April 1, 2025

Language: Английский