Case Studies in Chemical and Environmental Engineering, Год журнала: 2025, Номер unknown, С. 101114 - 101114
Опубликована: Янв. 1, 2025
Язык: Английский
Deleted Journal, Год журнала: 2025, Номер 2(2)
Опубликована: Янв. 13, 2025
This review examines the potential of nanomaterials in revolutionizing food packaging, focusing on their role enhancing barrier properties and extending shelf life packaged foods. Traditional packaging materials often fall short effectively protecting against oxygen, moisture, UV light, resulting diminished quality shorter life. Nanomaterials, including nanoclays, metal oxide nanoparticles (e.g., ZnO, TiO₂), carbon-based graphene, carbon nanotubes), biodegradable options like cellulose nanocrystals, have emerged as promising solutions. These offer exceptional gas moisture properties, antimicrobial effects, protection capabilities. The provides an in-depth exploration various nanomaterials, highlighting distinctive mechanisms; such tortuosity which enhance performance by limiting permeability. It also discusses recent advancements integrating into both flexible rigid systems, well active intelligent that employs nanosensors for real-time monitoring freshness spoilage. Despite potential, challenges toxicity concerns, environmental impacts, economic constraints to large-scale adoption are addressed. emphasizes need future research dual-function can simultaneously improve enable sensing. innovations could transform technologies, promoting enhanced safety sustainability.
Язык: Английский
Процитировано
8
Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114046 - 114046
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
5
Antibiotics, Год журнала: 2025, Номер 14(1), С. 57 - 57
Опубликована: Янв. 9, 2025
Antimicrobial resistance is a critical global challenge in the 21st century, validating Sir Alexander Fleming's warning about misuse of antibiotics leading to resistant microbes. With dwindling arsenal effective antibiotics, it imperative concentrate on alternative antimicrobial strategies. Previous studies have not comprehensively discussed advantages and limitations various strategies, including bacteriophage therapy, probiotics, immunotherapies, photodynamic essential oils, nanoparticles peptides (AMPs) within single review. This review addresses that gap by providing an overview these non-antibiotic highlighting their pros cons, with particular emphasis (AMPs). We explore mechanism action AMPs against bacteria, viruses, fungi parasites. While hold significant promise, application mainstream drug development hindered challenges such as low bioavailability potential toxicity. However, advancements peptide engineering chemical modifications offer solutions enhance clinical utility. Additionally, this presents updates strategies aimed at improving cost, stability selective toxicity through peptidomimetics. These molecules demonstrated activity broad range pathogens, making them valuable candidates for integration into surface coatings prevent device-associated infections. Furthermore, we discuss approaches attaching functionalising surfaces. Finally, recommend comprehensive vivo evaluate efficacy mimetics, investigate synergistic combinations other assess medical devices.
Язык: Английский
Процитировано
4
Antibiotics, Год журнала: 2025, Номер 14(3), С. 221 - 221
Опубликована: Фев. 21, 2025
Background/Objectives: Antimicrobial resistance poses a major public health challenge. The World Health Organization has identified 15 priority pathogens that require prompt development of new antibiotics. This review systematically evaluates the antibacterial most significant bacterial pathogens, currently available treatment options, as well complementary approaches for management infections caused by challenging multidrug-resistant (MDR) bacteria. For carbapenem-resistant Gram-negative bacteria, options include combinations beta-lactam antibiotics and beta-lactamase inhibitors, novel siderophore cephalosporin, known cefiderocol, older like polymixins tigecycline. Treatment Gram-positive bacteria are vancomycin, daptomycin, linezolid, etc. Although stagnated, various agents with properties in clinical preclinical trials. Non-antibiotic strategies encompass antibiotic potentiators, bacteriophage therapy, antivirulence therapeutics, antimicrobial peptides, nanomaterials, host-directed vaccines, antibodies, plant-based products, repurposed drugs, their combinations, including those used alongside Significant challenges exist developing antimicrobials, particularly related to scientific technical issues, along policy economic factors. Currently, alternative not part routine protocols. Conclusions Future Directions: There is an urgent need expedite treating MDR requires multidisciplinary approach involves collaboration across research, healthcare, regulatory bodies. Suggested crucial addressing this challenge should be backed rational use, enhanced infection control practices, improved surveillance systems emerging pathogens.
Язык: Английский
Процитировано
3
The Microbe, Год журнала: 2024, Номер 4, С. 100151 - 100151
Опубликована: Авг. 24, 2024
Язык: Английский
Процитировано
11
The Microbe, Год журнала: 2025, Номер unknown, С. 100281 - 100281
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2
Journal of Nanotheranostics, Год журнала: 2025, Номер 6(2), С. 9 - 9
Опубликована: Март 23, 2025
Antibiotic resistance poses a significant global health challenge, undermining the effectiveness of conventional treatments and increasing mortality rates worldwide. Factors such as overuse misuse antibiotics in healthcare agriculture, along with poor infection control practices, have accelerated emergence resistant bacterial strains. The stagnation development new antibiotics, compounded by economic biological challenges, has necessitated alternative approaches to combat infections. Nanotechnology provides promising solution using nanoparticles (NPs), which bacteria through mechanisms like membrane disruption reactive oxygen species (ROS) generation. Metal-based silver zinc oxide possess intrinsic antimicrobial properties, while polymer- carbon-based enhance drug delivery biofilm penetration. Unlike operate multi-mechanistic pathways, reducing likelihood improving treatment efficacy. This review aims provide an updated, in-depth look at recent advances nanoparticle research targeting antibiotic resistance, discussing different types nanoparticles, action, current challenges opportunities. By exploring evolving role nanotechnology addressing this crisis, intends highlight potential for transform landscape infections inspire further into these innovative solutions.
Язык: Английский
Процитировано
2
Materials Chemistry and Physics, Год журнала: 2025, Номер unknown, С. 130454 - 130454
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Archives of Microbiology, Год журнала: 2025, Номер 207(3)
Опубликована: Фев. 14, 2025
Язык: Английский
Процитировано
1
RSC Medicinal Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Lipopeptide-inspired, short peptide amphiphile-meropenem nanostructures enhance antibiotic efficacy, increase local concentration, reduce dosages, and minimize cytotoxicity, enabling efficient delivery to combat drug-resistant infections.
Язык: Английский
Процитировано
1