Copper-catalyzed perfluoroalkylation of propargyl gem-dichlorides DOI
Bosheng Liu,

Jinxu Dong,

Qi Zhu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

We developed a method for the copper-catalyzed coupling of propargyl gem -dichlorides with (DMPU) 2 Zn(R f ) to assemble chloro-substituted fluoroalkylated allenes. The reaction proceeds under mild conditions good functional group tolerance.

Language: Английский

Highly regio- and stereo-controlled synthesis of (Z)-4-(trifluoromethyl)-3-(phenylthio)-1-substituted-but-3-en-1-ynes via hydroalkynylation of alkynyl thioethers DOI

Akihiro Koga,

Takeshi Hanamoto

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

We carried out the first reaction of palladium-catalyzed hydroalkynylation alkynylthioethers with terminal acetylenes.

Language: Английский

Citations

0
Trifluoromethyl Group (CF3) Induced Regioselective Larock Indole Synthesis from Unsymmetric β-CF3-1,3-enynes DOI

Yan‐Hua Qiu,

Peng-Xiang Ma,

Wen‐Hao Shao

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

The indole skeleton exists widely in natural products, pharmaceuticals, and materials. We disclose here a trifluoromethyl group induced regioselective Larock synthetic method from unsymmetric 2-CF3-1,3-enynes. presence of is determinable for the regioselectivity. Once CF3 was replaced with methyl or phenyl group, ratio 1:1 to 1:1.4 isomers were obtained. This strategy features good regioselectivity, broad substrate scope, high functional tolerance. protocol reported offers an alternative solution rare 3,4-functionalization products further transformed show distinctive reactivity hydroboration–oxidation hydro-bromination.

Language: Английский

Citations

0
Electrochemical 1,5-chlorosulfonylation and 1,5-hydrosulfonylation of vinylcyclopropanes DOI
Xin Zhang, Wei Li,

Yuxiang Zhou

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(19), P. 5564 - 5572

Published: Jan. 1, 2024

This study reports the electrochemical reaction of vinylcyclopropanes with sulfonyl chlorides, resulting in 1,5-hydrosulfonylation and 1,5-chlorosulfonylation.

Language: Английский

Citations

1
Copper-catalyzed perfluoroalkylation of propargyl gem-dichlorides DOI
Bosheng Liu,

Jinxu Dong,

Qi Zhu

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

We developed a method for the copper-catalyzed coupling of propargyl gem -dichlorides with (DMPU) 2 Zn(R f ) to assemble chloro-substituted fluoroalkylated allenes. The reaction proceeds under mild conditions good functional group tolerance.

Language: Английский

Citations

1