Palladium-Catalyzed Tandem Reaction of β-Ketonitriles with Arylboronic Acids and Dimethyl Sulfoxide: Application to Multicomponent Synthesis of Poly-Substituted Pyridines

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

The Pd-catalyzed multicomponent tandem reaction of β-ketonitriles, arylboronic acids and DMSO was efficiently developed, enabling access to a variety poly substituted pyridines. protocol shows excellent chemoselectivity, generating nicotinonitriles or symmetrical tetrasubstituted pyridines under different conditions by cyclization enaminone intermediates with β-ketonitriles enolates, respectively, does not require extra ammonias. This method boasts notable advantages, such as the use commercially available easily prepared substrates, simple conditions, broad substrate scope, good functional group tolerance.

Язык: Английский

---

Facile Approach to Diverse Diarylmethane Scaffolds via DBU-Catalyzed 1,6-Addition Reaction: Discovery of an Antibacterial Agent

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Herein, a DBU-catalyzed 1,6-Michael addition of para-quinone methides (p-QMs) under mild reaction conditions with high efficiency (turnover number up to 103) and good excellent yields is reported. The transformation proceeds smoothly range nucleophiles, providing diverse diarylmethane scaffolds efficiency. Mechanistic studies revealed that DBU an proton acceptor donor can promote the methanol p-QMs. A preliminary investigation was also conducted antibacterial properties products.

Язык: Английский

---

Strain-Releasing Hydrogenation of Donor–Acceptor Cyclopropanes and Cyclobutanes via Electrochemical Site Selective Carbonyl Reduction

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

An acid or hydrogen gas-free electrochemical protocol is established for the hydrogenation of strained rings (cyclopropane and cyclobutane) at room temperature atmospheric pressure. The mechanistic study revealed that reaction was initiated via reduction carbonyl group. methodology highly specific toward such as cyclopropane cyclobutane, which exhibit broad functional group tolerance.

Язык: Английский

---

Electro-promoted radical-radical cross-coupling reaction to synthesize sulfonamides

Tetrahedron, Год журнала: 2024, Номер 168, С. 134315 - 134315

Опубликована: Окт. 20, 2024

Язык: Английский

---

Precisive Incorporation of Multiple Nitrogen Sources into Benzoxazoles via an Iodine-Mediated Electrochemical Four-Component Reaction

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

An iodine-mediated electrochemical four-component reaction was developed to construct aromatic C-N bonds by making use of a simple nitrogen source, such as NH

Язык: Английский

---