Precisive Incorporation of Multiple Nitrogen Sources into Benzoxazoles via an Iodine-Mediated Electrochemical Four-Component Reaction DOI

Tong Li,

Kai Li, Jiajia Yu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

An iodine-mediated electrochemical four-component reaction was developed to construct aromatic C-N bonds by making use of a simple nitrogen source, such as NH

Language: Английский

Palladium-Catalyzed Tandem Reaction of β-Ketonitriles with Arylboronic Acids and Dimethyl Sulfoxide: Application to Multicomponent Synthesis of Poly-Substituted Pyridines DOI

Ge Zeng,

Shi-Yan Wang,

Weiping Han

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

The Pd-catalyzed multicomponent tandem reaction of β-ketonitriles, arylboronic acids and DMSO was efficiently developed, enabling access to a variety poly substituted pyridines. protocol shows excellent chemoselectivity, generating nicotinonitriles or symmetrical tetrasubstituted pyridines under different conditions by cyclization enaminone intermediates with β-ketonitriles enolates, respectively, does not require extra ammonias. This method boasts notable advantages, such as the use commercially available easily prepared substrates, simple conditions, broad substrate scope, good functional group tolerance.

Language: Английский

Citations

0
Facile Approach to Diverse Diarylmethane Scaffolds via DBU-Catalyzed 1,6-Addition Reaction: Discovery of an Antibacterial Agent DOI Creative Commons
Pingda Ren, Yifei Li,

Shi-Yan Wang

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Herein, a DBU-catalyzed 1,6-Michael addition of para-quinone methides (p-QMs) under mild reaction conditions with high efficiency (turnover number up to 103) and good excellent yields is reported. The transformation proceeds smoothly range nucleophiles, providing diverse diarylmethane scaffolds efficiency. Mechanistic studies revealed that DBU an proton acceptor donor can promote the methanol p-QMs. A preliminary investigation was also conducted antibacterial properties products.

Language: Английский

Citations

0
Strain-Releasing Hydrogenation of Donor–Acceptor Cyclopropanes and Cyclobutanes via Electrochemical Site Selective Carbonyl Reduction DOI

Nakshatra Banerjee,

Rakesh Kumar,

Biswadeep Manna

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

An acid or hydrogen gas-free electrochemical protocol is established for the hydrogenation of strained rings (cyclopropane and cyclobutane) at room temperature atmospheric pressure. The mechanistic study revealed that reaction was initiated via reduction carbonyl group. methodology highly specific toward such as cyclopropane cyclobutane, which exhibit broad functional group tolerance.

Language: Английский

Citations

0
Electro-promoted radical-radical cross-coupling reaction to synthesize sulfonamides DOI
Hang Gong,

Hongmei Fu,

Chao Lü

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 168, P. 134315 - 134315

Published: Oct. 20, 2024

Language: Английский

Citations

0
Precisive Incorporation of Multiple Nitrogen Sources into Benzoxazoles via an Iodine-Mediated Electrochemical Four-Component Reaction DOI

Tong Li,

Kai Li, Jiajia Yu

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

An iodine-mediated electrochemical four-component reaction was developed to construct aromatic C-N bonds by making use of a simple nitrogen source, such as NH

Language: Английский

Citations

0