Regioselective Reversal in One-Pot and Two-Step Reaction of 1-(2-Hydroxyphenyl)-Propargyl Alcohols with Aryl/Alkyl Mercaptan: Construction of 3-(Alkylthio)benzofurans and 2-(Alkylthiomethyl)benzofurans Starting from Identical Materials

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 7, 2024

The Cu(MeCN)4PF6-catalyzed reaction of 1-(2-hydroxyphenyl)-propargyl alcohols with aryl/alkyl mercaptan and subsequent treatment K2CO3 only offered 3-(alkylthio)benzofurans, whereas the stoichiometric-exceeding CuI-mediated DIPEA furnished 2-(alkylthiomethyl)benzofurans high selectivity. amount Cu(I) salts plays a key role in selective formation. This unique protocol for construction two series benzofurans containing alkylthio group proved to be suitable broad substrates 1 2 except aliphatic alkynyl alcohols.

Язык: Английский

New Frontiers in Phosphorothioate Formation: Harnessing Inorganic Phosphorus Sources

Chemical Communications, Год журнала: 2024, Номер 60(99), С. 14691 - 14702

Опубликована: Янв. 1, 2024

This review highlights the latest advancements in synthesis of phosphorothioates and their derivatives from inorganic phosphorus sources, focusing on applicability, mechanisms, current limitations, potential future directions.

Язык: Английский