Investigating novel tubulin polymerization inhibitors: design, synthesis, LC/MS cellular permeability, in silico studies, and in vitro assessment DOI
Iman A. Y. Ghannam, Islam H. Ali, Rasha Z. Batran

et al.

Medicinal Chemistry Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Language: Английский

Unveiling the potential of isatin-grafted phenyl-1,2,3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments DOI

Heba A. Elsebaie,

Maha-Hamadien Abdulla,

Zainab M. Elsayed

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 151, P. 107626 - 107626

Published: July 10, 2024

Language: Английский

Citations

8
Design, synthesis and computational studies of new azaheterocyclic coumarin derivatives as anti-Mycobacterium tuberculosis agents targeting enoyl acyl carrier protein reductase (InhA) DOI Creative Commons
Rasha Z. Batran, Ahmed Sabt, Jarosław Dziadek

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(30), P. 21763 - 21777

Published: Jan. 1, 2024

In this study, we designed and synthesized a series of coumarin derivatives as antitubercular agents targeting the enoyl acyl carrier protein reductase (InhA) enzyme. Among compounds, tetrazole derivative 4c showed most potent effect with minimum inhibitory concentration value (MIC) 15 μg mL-1 against Mtb H37Rv could also inhibit growth mutant strain (ΔkatG). Compound was able to penetrate Mtb-infected human macrophages suppress intracellular tubercle bacilli. Moreover, target InhA enzyme an IC50 0.565 μM, which superior reference inhibitor triclosan. Molecular docking compound within active site revealed importance 4-phenylcoumarin ring system moiety for activity. Finally, physicochemical properties pharmacokinetic parameters were investigated.

Language: Английский

Citations

6
Undescribed diterpenes from Euphorbia mauritanica L. as modulators of the breast cancer resistance: Mechanistic and in silico studies DOI

Ahmed F. Essa,

Mai M. Elghonemy,

Rehab F. Taher

et al.

Phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 114418 - 114418

Published: Jan. 1, 2025

Language: Английский

Citations

0
Synthesis and Mechanistic Insights of Coumarinyl-Indolinone Hybrids as Potent Inhibitors of Leishmania major DOI
Rasha Z. Batran, Manal S Ebaid, Sherry N. Nasralla

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117392 - 117392

Published: Feb. 1, 2025

Language: Английский

Citations

0
Exploring antitubercular activity of new coumarin derivatives targeting enoyl acyl carrier protein reductase (InhA): Synthesis, biological evaluation and computational studies DOI
Manal S Ebaid,

Małgorzata Korycka-Machała,

Moataz A. Shaldam

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142074 - 142074

Published: March 1, 2025

Language: Английский

Citations

0
New coumarin linked thiazole derivatives as antimycobacterial agents: Design, synthesis, enoyl acyl carrier protein reductase (InhA) inhibition and molecular modeling DOI
Asmaa F. Kassem, Ahmed Sabt,

Małgorzata Korycka-Machała

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107511 - 107511

Published: May 31, 2024

Language: Английский

Citations

3
Biosynthesis of selenium nanoparticles as a potential therapeutic agent in breast cancer: G2/M arrest and apoptosis induction DOI Creative Commons
Basant A. Ali, Rasha M. Allam, Mohamed S. Hasanin

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101792 - 101792

Published: Oct. 25, 2024

Language: Английский

Citations

2
Ursolic acid interaction with transcription factors BRAF, V600E, and V600K: a computational approach towards new potential melanoma treatments DOI
Giovanny Aguilera-Durán,

Stephanie Hernández-Castro,

Brenda V. Loera-García

et al.

Journal of Molecular Modeling, Journal Year: 2024, Volume and Issue: 30(11)

Published: Oct. 10, 2024

Language: Английский

Citations

0
Investigating novel tubulin polymerization inhibitors: design, synthesis, LC/MS cellular permeability, in silico studies, and in vitro assessment DOI
Iman A. Y. Ghannam, Islam H. Ali, Rasha Z. Batran

et al.

Medicinal Chemistry Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Language: Английский

Citations

0