A BODIPY-Naphtholimine-BF2 Dyad for Precision Photodynamic Therapy, Targeting, and Dual Imaging of Endoplasmic Reticulum and Lipid Droplets in Cancer
JACS Au,
Год журнала:
2024,
Номер
4(8), С. 2838 - 2852
Опубликована: Июнь 5, 2024
Currently,
effective
therapeutic
modalities
for
pancreatic
ductal
adenocarcinoma
(PDAC)
are
quite
limited,
leading
to
gloomy
prognosis
and
∼6-months
median
patient
survival.
Recent
advances
showed
the
promise
of
photodynamic
therapy
(PDT)
PDAC
patients.
Next
generation
photosensitizers
(PS)
based
on
"organelle-targeted-PDT"
provide
new
paradigm
in
field
precision
medicines
address
current
challenge
treating
PDAC.
In
this
investigation,
we
have
constructed
a
novel
PS,
named
as
Язык: Английский
Amino‐Terephthalonitrile Based Single Benzene Fluorophores Bearing Amino Esters and Lipids for Selective Biothiol Sensing and Bioimaging
Asian Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Abstract
We
report
here
the
preparation
of
eight
new
AmTN
SBFs
which
feature
amino
esters
with
an
N‐terminal
fluorophore
and
also
lipophilic
dyes,
consisting
a
push‐pull
moiety.
Spectrofluorimetric
NMR
titration
investigations
reveal
preference
terephthalonitirle
ring
in
mono
AmTNs
towards
rapid
sensing
N‐acetyl
cysteine,
as
opposed
to
dipeptide
carnosine.
This
has
significance
field
bioanalysis
whereby
could
show
their
potential
thiol
platforms.
Also,
one
green
emissive
featuring
two
cyclohexyl
units
proved
its
worth
fluorescence
imaging
using
C2
C12
cells,
where
it
localized
electively
inside
cell
cytoplasm
at
concentration
1
μM.
Язык: Английский
A novel FRET-based fluorescent probe capable of simultaneously imaging lipid droplets and the endoplasmic reticulum with two distinct fluorescence signals in HeLa cells
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy,
Год журнала:
2025,
Номер
unknown, С. 126262 - 126262
Опубликована: Апрель 1, 2025
Язык: Английский
Fluorescence Lifetime Imaging: A Novel Approach to Simultaneous Visualizing Lipid Droplets and Endoplasmic Reticulum Polarity in Live Cells and Fatty Liver
Sensors and Actuators B Chemical,
Год журнала:
2024,
Номер
unknown, С. 136699 - 136699
Опубликована: Сен. 1, 2024
Язык: Английский
A novel fluorescent probe for viscosity and polarity detection in real tobacco root cells and biological imaging
Yuan He,
Long-Ke Li,
Maohua Wang
и другие.
Photochemical & Photobiological Sciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Multi-Organelle Imaging with Dye Combinations: Targeting the ER, Mitochondria, and Plasma Membrane
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
Multi-organelle
imaging
allows
the
visualization
of
multiple
organelles
within
a
single
cell,
allowing
monitoring
cellular
processes
in
real-time
using
various
fluorescent
probes
that
target
specific
organelles.
However,
limited
availability
fluorophores
and
potential
spectral
overlap
present
challenges,
many
optimized
designs
are
still
nascency.
In
this
work,
we
synthesized
sulfonamide-based
organic
emit
blue,
green,
red
regions
to
different
sub-cellular
By
utilizing
binary
mixtures,
successfully
demonstrated
organelles,
such
as
endoplasmic
reticulum,
plasma
membrane,
mitochondria
HeLa
cells,
dual
reticulum
A549
lung
carcinoma
cells
with
help
blue
red-emitting
without
any
spillover.
Additionally,
these
photostable
allowed
precise
cell
staining
differentiation,
structural
features,
live
dynamics.
This
approach
mixtures
can
gain
traction
for
studies
investigations.
Язык: Английский