Advancing Cancer Therapy with Quantum Dots and Other Nanostructures: A Review of Drug Delivery Innovations, Applications, and Challenges

Cancers, Год журнала: 2025, Номер 17(5), С. 878 - 878

Опубликована: Март 4, 2025

Nanotechnology, particularly quantum dots (QDs), has ushered in a transformative era the pharmaceutical and medical industries, offering notable opportunities for nanoscale advancements. These particles, known their exceptional optical properties confinement, have emerged as indispensable tools cancer drug delivery bioimaging. This review delves into various conjugation techniques with QDs, including covalent linking, non-covalent conjugation, click chemistry, disulfide linkage, pH-sensitive linkage. Each method provides distinct advantages, such enhanced stability, reversibility, specificity, controlled release. Moreover, QDs demonstrated significant promise oncology by efficiently delivering drugs to cancerous tissues while minimising systemic toxicity. Investigations applications different cancers, blood, brain, cervical, breast etc., reveal efficacy targeted delivery, real-time imaging, improved therapeutic outcomes. However, challenges potential toxicity, pharmacokinetics, targeting specificity must be addressed fully harness benefits of therapy. Future research should focus on developing biocompatible optimising techniques, elucidating safety profiles long-term effects biological systems. Overall, represent promising frontier treatment, multifaceted capabilities that hold outcomes reduced side across cancers.

Язык: Английский

---

The role of graphene quantum dots in cutting‐edge medical therapies

Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(9)

Опубликована: Сен. 1, 2024

Abstract Graphene quantum dots (GQDs), owing to their unique optical, electrical, and chemical properties, have emerged as promising nanomaterials for various biomedical applications. This review provides a comprehensive overview of the latest advancements in utilization GQDs tissue engineering, wound healing, drug delivery systems, other therapies. The inherent properties GQDs, including high biocompatibility, tunable photoluminescence, significant surface area, make them ideal candidates enhancing medical treatments diagnostics. In improve mechanical biological performance scaffolds, promoting cell proliferation differentiation. For enhance antimicrobial activity facilitate faster regeneration. Their potential DDS is highlighted by ability deliver therapeutic agents efficiently, ensuring targeted controlled release. Additionally, play crucial role therapies, particularly cancer treatment, efficacy reducing side effects. While offer diagnostics, challenges such understanding long‐term cytotoxicity at higher concentrations, need standardized synthesis methods remain critical areas further research. also discusses future directions opportunities emphasizing transformative advancing modern healthcare solutions. insights presented here contribute expanding field GQD research, highlighting significantly patient outcomes drive innovations.

Язык: Английский

---

Recent breakthroughs in graphene quantum dot-enhanced sonodynamic and photodynamic therapy

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(29), С. 7041 - 7062

Опубликована: Янв. 1, 2024

Water-soluble graphene quantum dots (GQDs) have recently exhibited considerable potential for diverse biomedical applications owing to their exceptional optical and chemical properties.

Язык: Английский

---

Graphene Quantum Dots from Natural Carbon Sources for Drug and Gene Delivery in Cancer Treatment

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10539 - 10539

Опубликована: Сен. 30, 2024

Cancer therapy is constantly evolving, with a growing emphasis on targeted and efficient treatment options. In this context, graphene quantum dots (GQDs) have emerged as promising agents for precise drug gene delivery due to their unique attributes, such high surface area, photoluminescence, up-conversion biocompatibility. GQDs can damage cancer cells exhibit intrinsic photothermal conversion singlet oxygen generation efficiency under specific light irradiation, enhancing effectiveness. They serve direct therapeutic versatile platforms capable of being easily functionalized various targeting molecules agents. However, challenges achieving uniform size morphology, bandgap engineering, scalability, along minimizing cytotoxicity the environmental impact production, must be addressed. Additionally, there need more comprehensive understanding cellular mechanisms release processes, well improved purification methods. Integrating into existing systems enhances efficacy traditional treatments, offering less invasive options patients. This review highlights transformative potential in while acknowledging that researchers overcome broader application.

Язык: Английский

---

Unveiling the potential of photodynamic therapy with nanocarriers as a compelling therapeutic approach for skin cancer treatment: current explorations and insights

RSC Advances, Год журнала: 2024, Номер 14(30), С. 21915 - 21937

Опубликована: Янв. 1, 2024

Skin carcinoma is one of the most prevalent types carcinomas. Due to high incidence side effects in conventional therapies (radiotherapy and chemotherapy), photodynamic therapy (PDT) has gained huge attention as an alternate treatment strategy. PDT involves administration photosensitizers (PS) cells which produce reactive oxygen species (ROS) on irradiation by specific wavelengths light that result cancer cells' death

Язык: Английский

---

Current views and trends of nanomaterials as vectors for gene delivery since the 21st century: a bibliometric analysis

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Янв. 29, 2025

Gene therapy is garnering increasing support due to its potential for a "once-delivered, lifelong benefit." The limitations of traditional gene delivery methods have spurred the advancement bionanomaterials. Despite this progress, thorough analysis evolution, current state, key contributors, focal studies, and future directions nanomaterials in remains absent. This study scrutinizes articles from Web Science, spanning 1 January 2 000, 31 December 2023, employing various online tools visualization. 21st century has witnessed consistent growth scholarly work domain globally, with notable contributions China US. At same time, Chinese Academy Sciences (CAS), Harvard University, Massachusetts Institute Technology (MIT) emerged as most productive institutions, CAS's academician Weihong Tan becoming field's leading author. While drug nanoparticles (NPs) been central themes two decades, research focus shifted modifying NPs ultrafine particles exploring polymer-hybrid NPs, mRNA vaccines, immune responses, green synthesis, CRISPR/Cas tools. shift marks transition insights provided by offer comprehensive overview field valuable guidance investigations.

Язык: Английский

---

Dual-action approach to oral cancer therapy: integrating HDAC inhibition and photodynamic therapy with LXD191

Lasers in Medical Science, Год журнала: 2025, Номер 40(1)

Опубликована: Фев. 17, 2025

Язык: Английский

---

Multifunctional sorafenib-loaded MXene for enhanced cancer therapy: In vitro and in vivo study based on chemotherapy/photothermal therapy approach

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125492 - 125492

Опубликована: Март 1, 2025

Язык: Английский

---

A holistic review on red fluorescent graphene quantum dots, its synthesis, unique properties with emphasis on biomedical applications

Heliyon, Год журнала: 2024, Номер 10(16), С. e35760 - e35760

Опубликована: Авг. 1, 2024

Graphene quantum dots (GQDs) are an evolving class of carbon-based nanomaterial, seizing tremendous attention owing to their intense optical property, engineered shapes and structures, good photostability. Being a zero-dimensional form carbon structure, GQDs have superior photoluminescent behavior, tunable emission absorption, excellent biocompatibility, low cytotoxicity, hydrophilic nature, modifying surface states. Their water dispersibility functionalized involving heteroatoms various functional groups onto the GQDs, make them particularly suitable for biological applications. Based on absolute luminescence properties, emit blue, green, yellow, red light under ultraviolet irradiation. Amongst three colors, can achieve deeper penetration into tissues, cellular distribution, bio-sensing cell imaging, drug delivery, serves as better candidate photodynamic therapy. The overall objective this review is provide comprehensive overview synthesis methods fluorescence graphene (RF-GQDs), critical comparative analyses spectral techniques used characterization, photoluminescence mechanisms underpinning emission, significance chemically functionalizing GQDs' edges in achieving discussed depth. This also discusses effective applications challenges associated with RF-GQDs examined, providing insights future potential clinical industrial

Язык: Английский

---

Graphene quantum dots as nanotherapeutic agents for triple-negative breast cancer: Insights from 3D tumor models

Coordination Chemistry Reviews, Год журнала: 2024, Номер 523, С. 216247 - 216247

Опубликована: Окт. 7, 2024

Язык: Английский

---