A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials
Gels,
Год журнала:
2024,
Номер
10(11), С. 693 - 693
Опубликована: Окт. 25, 2024
Hydrogels
are
known
for
their
high
water
retention
capacity
and
biocompatibility
have
become
essential
materials
in
tissue
engineering
drug
delivery
systems.
This
review
explores
recent
advancements
hydrogel
technology,
focusing
on
innovative
types
such
as
self-healing,
tough,
smart,
hybrid
hydrogels,
each
engineered
to
overcome
the
limitations
of
conventional
hydrogels.
Self-healing
hydrogels
can
autonomously
repair
structural
damage,
making
them
well-suited
applications
dynamic
biomedical
environments.
Tough
designed
with
enhanced
mechanical
properties,
enabling
use
load-bearing
cartilage
regeneration.
Smart
respond
external
stimuli,
including
changes
pH,
temperature,
electromagnetic
fields,
ideal
controlled
release
tailored
specific
medical
needs.
Hybrid
made
from
both
natural
synthetic
polymers,
combine
bioactivity
resilience,
which
is
particularly
valuable
complex
tissues.
Despite
these
innovations,
challenges
optimizing
biocompatibility,
adjusting
degradation
rates,
scaling
up
production
remain.
provides
an
in-depth
analysis
emerging
technologies,
highlighting
transformative
potential
while
outlining
future
directions
development
applications.
Язык: Английский
Metal-based antimicrobial agents in wound Dressings: Infection management and the challenge of antibiotic resistance
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160726 - 160726
Опубликована: Фев. 1, 2025
Язык: Английский
Breathable core–shell microneedle patches for diabetic wound treatment
Materials Futures,
Год журнала:
2025,
Номер
4(2), С. 025402 - 025402
Опубликована: Апрель 23, 2025
Abstract
Microneedles
have
demonstrated
valuable
applications
in
diabetic
wound
management.
Many
endeavors
are
devoted
to
developing
microneedles
with
well-designed
structures
and
enhanced
functions.
Herein,
we
present
an
elaborate
microneedle
patch
breathability
for
healing
by
a
multi-step
replication
method.
The
consists
of
breathable
porous
supporting
substrate
core–shell
tips
involving
poly
(vinyl
alcohol)
shells
loaded
antimicrobial
peptides
(PVA@AMPs
shell)
crosslinked
Gelma
cores
encapsulated
exosomes
(Gelma@exo
core).
PVA
was
ROS-responsive
linker,
which
results
degradation
the
shell
inflammatory
microenvironment,
thus
inducing
release
AMPs
inhibit
bacteria.
Further,
continuously
from
exposed
Gelma@exo
core,
promoting
tissue
regeneration
regulating
immune
response.
Besides,
high
porosity
makes
patches
more
suitable
chronic
wounds.
Based
on
these
features,
it
that
exhibits
desirable
performance
vivo
animal
tests.
Thus,
believe
proposed
remarkable
potential
related
fields.
Язык: Английский
A Versatile Composite Hydrogel with Spatiotemporal Drug Delivery of Mesoporous ZnO and Recombinant Human Collagen for Diabetic Infected Wound Healing
Biomacromolecules,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Diabetic
wounds
are
increasingly
common
and
challenging
to
treat
due
high
infection
risks
in
a
high-glucose
environment.
Effective
treatment
requires
wound
dressings
that
combat
infections,
while
promoting
angiogenesis
skin
regeneration.
This
study
presents
hydrogel-based
drug
delivery
system
made
from
cellulose
designed
accelerate
diabetic
healing
by
eliminating
bacterial
infections.
The
hydrogel,
formed
linking
phenylboronic
acid-grafted
oxidized
methylcellulose
(POMC)
with
poly(vinyl
alcohol)
(PVA),
exhibits
self-healing
injectable
properties.
It
is
further
enhanced
adding
type
I
recombinant
human
collagen
(rhCOL1)
stimulate
cell
growth
mesoporous
zinc
oxide
(mZnO)
for
antibacterial
anti-inflammatory
effects.
Upon
application,
the
hydrogel
degrades
under
pH/ROS
stimuli,
releasing
mZnO
rhCOL1
controlled
manner
matches
stages.
In
vivo
tests
show
effectively
eliminates
bacteria,
reduces
inflammation,
promotes
rapid
regeneration,
making
it
promising
solution
treating
wounds.
Язык: Английский