A Versatile Composite Hydrogel with Spatiotemporal Drug Delivery of Mesoporous ZnO and Recombinant Human Collagen for Diabetic Infected Wound Healing DOI

Ye Wu,

Cheng Hu, Yaxing Li

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Diabetic wounds are increasingly common and challenging to treat due high infection risks in a high-glucose environment. Effective treatment requires wound dressings that combat infections, while promoting angiogenesis skin regeneration. This study presents hydrogel-based drug delivery system made from cellulose designed accelerate diabetic healing by eliminating bacterial infections. The hydrogel, formed linking phenylboronic acid-grafted oxidized methylcellulose (POMC) with poly(vinyl alcohol) (PVA), exhibits self-healing injectable properties. It is further enhanced adding type I recombinant human collagen (rhCOL1) stimulate cell growth mesoporous zinc oxide (mZnO) for antibacterial anti-inflammatory effects. Upon application, the hydrogel degrades under pH/ROS stimuli, releasing mZnO rhCOL1 controlled manner matches stages. In vivo tests show effectively eliminates bacteria, reduces inflammation, promotes rapid regeneration, making it promising solution treating wounds.

Language: Английский

A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials DOI Creative Commons
Hoon Choi, Wan-Sun Choi,

Jin-Oh Jeong

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 693 - 693

Published: Oct. 25, 2024

Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.

Language: Английский

Citations

10
Metal-based antimicrobial agents in wound Dressings: Infection management and the challenge of antibiotic resistance DOI

Haihong Peng,

Derong Dong, Sizhou Feng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160726 - 160726

Published: Feb. 1, 2025

Language: Английский

Citations

0
Breathable core–shell microneedle patches for diabetic wound treatment DOI Creative Commons
Lu Fan, Yu Wang, Li Wang

et al.

Materials Futures, Journal Year: 2025, Volume and Issue: 4(2), P. 025402 - 025402

Published: April 23, 2025

Abstract Microneedles have demonstrated valuable applications in diabetic wound management. Many endeavors are devoted to developing microneedles with well-designed structures and enhanced functions. Herein, we present an elaborate microneedle patch breathability for healing by a multi-step replication method. The consists of breathable porous supporting substrate core–shell tips involving poly (vinyl alcohol) shells loaded antimicrobial peptides (PVA@AMPs shell) crosslinked Gelma cores encapsulated exosomes (Gelma@exo core). PVA was ROS-responsive linker, which results degradation the shell inflammatory microenvironment, thus inducing release AMPs inhibit bacteria. Further, continuously from exposed Gelma@exo core, promoting tissue regeneration regulating immune response. Besides, high porosity makes patches more suitable chronic wounds. Based on these features, it that exhibits desirable performance vivo animal tests. Thus, believe proposed remarkable potential related fields.

Language: Английский

Citations

0
A Versatile Composite Hydrogel with Spatiotemporal Drug Delivery of Mesoporous ZnO and Recombinant Human Collagen for Diabetic Infected Wound Healing DOI

Ye Wu,

Cheng Hu, Yaxing Li

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Diabetic wounds are increasingly common and challenging to treat due high infection risks in a high-glucose environment. Effective treatment requires wound dressings that combat infections, while promoting angiogenesis skin regeneration. This study presents hydrogel-based drug delivery system made from cellulose designed accelerate diabetic healing by eliminating bacterial infections. The hydrogel, formed linking phenylboronic acid-grafted oxidized methylcellulose (POMC) with poly(vinyl alcohol) (PVA), exhibits self-healing injectable properties. It is further enhanced adding type I recombinant human collagen (rhCOL1) stimulate cell growth mesoporous zinc oxide (mZnO) for antibacterial anti-inflammatory effects. Upon application, the hydrogel degrades under pH/ROS stimuli, releasing mZnO rhCOL1 controlled manner matches stages. In vivo tests show effectively eliminates bacteria, reduces inflammation, promotes rapid regeneration, making it promising solution treating wounds.

Language: Английский

Citations

0