IONPs-induced neurotoxicity via cascade of neuro-oxidative stress, parthanatos-mediated cell death, neuro-inflammation and neurodegenerative changes: Ameliorating effect of rosemary methanolic extract
Toxicology Reports,
Год журнала:
2025,
Номер
14, С. 101935 - 101935
Опубликована: Янв. 31, 2025
Язык: Английский
Alterations in protein quality control resulting in neurodegeneration and disease
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 123 - 175
Опубликована: Янв. 1, 2025
Язык: Английский
Pharmaceutical 3D Printing Technology Integrating Nanomaterials and Nanodevices for Precision Neurological Therapies
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 352 - 352
Опубликована: Март 9, 2025
Pharmaceutical
3D
printing,
combined
with
nanomaterials
and
nanodevices,
presents
a
transformative
approach
to
precision
medicine
for
treating
neurological
diseases.
This
technology
enables
the
creation
of
tailored
dosage
forms
controlled
release
profiles,
enhancing
drug
delivery
across
blood−brain
barrier
(BBB).
The
integration
nanoparticles,
such
as
poly
lactic-co-glycolic
acid
(PLGA),
chitosan,
metallic
nanomaterials,
into
3D-printed
scaffolds
improves
treatment
efficacy
by
providing
targeted
prolonged
release.
Recent
advances
have
demonstrated
potential
these
systems
in
conditions
like
Parkinson’s
disease,
epilepsy,
brain
tumors.
Moreover,
printing
allows
multi-drug
combinations
personalized
formulations
that
adapt
individual
patient
needs.
Novel
approaches,
including
stimuli-responsive
systems,
on-demand
dosing,
theragnostics,
provide
new
possibilities
real-time
monitoring
disorders.
Despite
innovations,
challenges
remain
terms
scalability,
regulatory
approval,
long-term
safety.
future
perspectives
this
suggest
its
revolutionize
treatments
offering
patient-specific
therapies,
improved
penetration,
enhanced
outcomes.
review
discusses
current
state,
applications,
nanotechnology
treatment,
highlighting
need
further
research
overcome
existing
challenges.
Язык: Английский
Parallelized Mechanical Stimulation of Neuronal Calcium Through Cell‐Internal Nanomagnetic Forces Provokes Lasting Shifts in the Network Activity State
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 26, 2024
Abstract
Neurons
differentiate
mechanical
stimuli
force
and
rate
to
elicit
unique
functional
responses,
driving
the
need
for
further
tools
generate
various
stimuli.
Here,
cell‐internal
nanomagnetic
forces
(iNMF)
are
introduced
by
manipulating
internalized
magnetic
nanoparticles
with
an
external
field
across
cortical
neuron
networks
in
vitro.
Under
iNMF,
neurons
exhibit
calcium
(Ca
2+
)
influx,
leading
modulation
of
activity
observed
through
Ca
event
rates.
Inhibiting
particle
uptake
or
altering
nanoparticle
exposure
time
reduced
neuronal
response
forces,
exposing
requirement
induce
response.
In
highly
active
networks,
iNMF
robustly
modulates
synchronous
network
activity,
which
is
lasting
repeatable.
Using
pharmacological
blockers,
it
shown
that
activates
mechanosensitive
ion
channels
influx.
Then,
contrast
transient
mechanically
evoked
‐activated
potassium
(K
stabilize
membrane
potential
shifts.
The
findings
reveal
nanoparticle‐mediated
stimulation
modulate
circuit
dynamics,
providing
insights
into
biophysics
computation.
Язык: Английский
Innovative strategies for overcoming blood-brain barrier challenges in Alzheimer’s disease: A focus on green-synthesized metallic nanoparticles
Inorganic Chemistry Communications,
Год журнала:
2024,
Номер
unknown, С. 113604 - 113604
Опубликована: Ноя. 1, 2024
Язык: Английский
Revolutionizing healthcare: inorganic medicinal nanoarchitectonics for advanced theranostics
Nanoscale Horizons,
Год журнала:
2024,
Номер
10(3), С. 460 - 483
Опубликована: Ноя. 22, 2024
Over
the
last
two
decades,
advancements
in
nanomaterials
and
nanoscience
have
paved
path
for
emergence
of
nano-medical
convergence
science,
significantly
impacting
healthcare.
In
our
review,
we
highlight
how
these
are
applied
various
biomedical
technologies
such
as
drug
delivery
systems,
bio-imaging
diagnostic
therapeutic
purposes.
Recently,
novel
inorganic
nanohybrid
drugs
been
developed,
combining
multifunctional
with
agents
(known
medicinal
nanoarchitectonics).
These
innovative
actively
utilized
cutting-edge
medical
treatments,
including
targeted
anti-cancer
therapy,
photo
radiation
immunotherapy.
This
review
provides
a
detailed
overview
current
development
status
nanoarchitectonics
explores
potential
future
directions
their
advancements.
Язык: Английский