IONPs-induced neurotoxicity via cascade of neuro-oxidative stress, parthanatos-mediated cell death, neuro-inflammation and neurodegenerative changes: Ameliorating effect of rosemary methanolic extract

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101935 - 101935

Published: Jan. 31, 2025

Language: Английский

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Alterations in protein quality control resulting in neurodegeneration and disease

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 123 - 175

Published: Jan. 1, 2025

Language: Английский

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Pharmaceutical 3D Printing Technology Integrating Nanomaterials and Nanodevices for Precision Neurological Therapies

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 352 - 352

Published: March 9, 2025

Pharmaceutical 3D printing, combined with nanomaterials and nanodevices, presents a transformative approach to precision medicine for treating neurological diseases. This technology enables the creation of tailored dosage forms controlled release profiles, enhancing drug delivery across blood−brain barrier (BBB). The integration nanoparticles, such as poly lactic-co-glycolic acid (PLGA), chitosan, metallic nanomaterials, into 3D-printed scaffolds improves treatment efficacy by providing targeted prolonged release. Recent advances have demonstrated potential these systems in conditions like Parkinson’s disease, epilepsy, brain tumors. Moreover, printing allows multi-drug combinations personalized formulations that adapt individual patient needs. Novel approaches, including stimuli-responsive systems, on-demand dosing, theragnostics, provide new possibilities real-time monitoring disorders. Despite innovations, challenges remain terms scalability, regulatory approval, long-term safety. future perspectives this suggest its revolutionize treatments offering patient-specific therapies, improved penetration, enhanced outcomes. review discusses current state, applications, nanotechnology treatment, highlighting need further research overcome existing challenges.

Language: Английский

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Development and characterization of ciprofloxacin-loaded mesoporous silica-coated superparamagnetic iron oxide nanoparticles: Antioxidant, antimicrobial, and anticancer activity

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114589 - 114589

Published: May 1, 2025

Language: Английский

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Parallelized Mechanical Stimulation of Neuronal Calcium Through Cell‐Internal Nanomagnetic Forces Provokes Lasting Shifts in the Network Activity State

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

Abstract Neurons differentiate mechanical stimuli force and rate to elicit unique functional responses, driving the need for further tools generate various stimuli. Here, cell‐internal nanomagnetic forces (iNMF) are introduced by manipulating internalized magnetic nanoparticles with an external field across cortical neuron networks in vitro. Under iNMF, neurons exhibit calcium (Ca 2+ ) influx, leading modulation of activity observed through Ca event rates. Inhibiting particle uptake or altering nanoparticle exposure time reduced neuronal response forces, exposing requirement induce response. In highly active networks, iNMF robustly modulates synchronous network activity, which is lasting repeatable. Using pharmacological blockers, it shown that activates mechanosensitive ion channels influx. Then, contrast transient mechanically evoked ‐activated potassium (K stabilize membrane potential shifts. The findings reveal nanoparticle‐mediated stimulation modulate circuit dynamics, providing insights into biophysics computation.

Language: Английский

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Innovative strategies for overcoming blood-brain barrier challenges in Alzheimer’s disease: A focus on green-synthesized metallic nanoparticles

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: unknown, P. 113604 - 113604

Published: Nov. 1, 2024

Language: Английский

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Revolutionizing healthcare: inorganic medicinal nanoarchitectonics for advanced theranostics

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 10(3), P. 460 - 483

Published: Nov. 22, 2024

Over the last two decades, advancements in nanomaterials and nanoscience have paved path for emergence of nano-medical convergence science, significantly impacting healthcare. In our review, we highlight how these are applied various biomedical technologies such as drug delivery systems, bio-imaging diagnostic therapeutic purposes. Recently, novel inorganic nanohybrid drugs been developed, combining multifunctional with agents (known medicinal nanoarchitectonics). These innovative actively utilized cutting-edge medical treatments, including targeted anti-cancer therapy, photo radiation immunotherapy. This review provides a detailed overview current development status nanoarchitectonics explores potential future directions their advancements.

Language: Английский

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