Journal of Neuroscience,
Год журнала:
2014,
Номер
34(19), С. 6624 - 6633
Опубликована: Май 7, 2014
Neural
stem
cells
in
the
adult
mammalian
hippocampus
continuously
generate
new
functional
neurons,
which
modify
hippocampal
network
and
significantly
contribute
to
cognitive
processes
mood
regulation.
Here,
we
show
that
development
of
neurons
from
mice
is
paralleled
by
extensive
changes
mitochondrial
mass,
distribution,
shape.
Moreover,
exercise—a
strong
modifier
neurogenesis—accelerates
neuronal
maturation
induces
a
profound
increase
content
presence
mitochondria
dendritic
segments.
Genetic
inhibition
activity
fission
factor
dynamin-related
protein
1
(Drp1)
inhibits
neurogenesis
under
basal
exercise
conditions.
Conversely,
enhanced
Drp1
furthers
exercise-induced
acceleration
maturation.
Collectively,
these
results
indicate
requires
adaptation
compartment
suggest
are
targets
for
enhancing
neurogenesis-dependent
plasticity.
Current Neuropharmacology,
Год журнала:
2016,
Номер
14(6), С. 610 - 618
Опубликована: Июнь 27, 2016
Background:
Depression
is
the
most
debilitating
neuropsychiatric
disorder
with
significant
impact
on
socio-occupational
and
well
being
of
individual.
The
exact
pathophysiology
depression
still
enigmatic
though
various
theories
have
been
put
forwarded.
There
are
evidences
showing
that
mitochondrial
dysfunction
in
brain
regions
associated
depression.
Recent
findings
sparked
renewed
appreciation
for
role
mitochondria
many
intracellular
processes
coupled
to
synaptic
plasticity
cellular
resilience.
New
insights
revolving
around
impairment
neuroplasticity.
Mitochondria
potential
ATP
production,
Ca2+
signalling
establish
membrane
stability,
reactive
oxygen
species
(ROS)
balance
execute
complex
neurotransmission
plasticity.
So
understanding
concepts
pathogenesis
indubitably
helps
generate
novel
more
targeted
therapeutic
approaches
treatment.
Objective:
review
was
aimed
give
a
comprehensive
insight
Result:
Targeting
enhancing
functions
might
act
as
target
treatment
Conclusion:
Literature
cited
this
highly
supports
As
lead
generation
insults
exaggerate
So,
it
useful
study
relation
mood
disorders,
plasticity,
neurogenesis
show
promiscuous
effects
depressed
patients.
Keywords:
Depression,
Mitochondrial
dysfunction,
Reactive
species,
neurotransmitter,
Mitochondria,
electron
transport
chain.
Neuropsychopharmacology,
Год журнала:
2017,
Номер
43(1), С. 4 - 20
Опубликована: Сен. 1, 2017
Endocannabinoids
(eCBs)
are
amongst
the
most
ubiquitous
signaling
molecules
in
nervous
system.
Over
past
few
decades,
observations
based
on
a
large
volume
of
work,
first
examining
pharmacological
effects
exogenous
cannabinoids,
and
then
physiological
functions
eCBs,
have
directly
challenged
long-held
dogmatic
views
about
communication,
plasticity
behavior
central
system
(CNS).
The
eCBs
their
cognate
cannabinoid
receptors
exhibit
number
unique
properties
that
distinguish
them
from
widely
studied
classical
amino-acid
transmitters,
neuropeptides,
catecholamines.
Although
we
now
loose
set
mechanistic
rules
experimental
findings,
new
studies
continue
to
reveal
our
understanding
eCB
(ECS)
is
continuously
evolving
challenging
conventions.
Here
will
briefly
summarize
findings
current
canonical
view
‘ECS’
address
novel
aspects
how
nearly
can
determine
highly
specific
brain.
In
particular,
focus
push
for
an
expansion
ideas
around
beliefs
that,
while
clearly
true,
may
be
contributing
oversimplified
perspective
at
microscopic
level
impacts
macroscopic
level.
Proceedings of the National Academy of Sciences,
Год журнала:
2015,
Номер
112(50), С. 15486 - 15491
Опубликована: Ноя. 30, 2015
Significance
Within
a
dominance
hierarchy,
low
social
status
strongly
reduces
individual
well-being.
In
socially
living
species,
rank
in
hierarchy
is
determined
through
competitive
encounters.
Despite
the
numerous
health
consequences,
ability
of
personality
traits
to
predispose
individuals
particular
remains
largely
unclear.
Our
work
identifies
trait
anxiety
as
predisposing
factor
subordinate
rank.
We
demonstrate
that
mitochondrial
function
nucleus
accumbens,
brain
region
relevant
for
motivation
and
depression,
critical
mediating
displayed
by
high-anxious
rats.
These
findings
highlight
role
cerebral
energy
metabolism
behavior
point
accumbens
potential
marker
avenue
treatment
mood
disorders.
Current Neuropharmacology,
Год журнала:
2016,
Номер
15(1), С. 166 - 173
Опубликована: Апрель 19, 2016
Synaptic
plasticity
in
the
adult
brain
is
believed
to
represent
cellular
mechanisms
of
learning
and
memory.
Mitochondria
are
involved
regulation
complex
processes
synaptic
plasticity.
This
paper
reviews
current
knowledge
on
regulatory
roles
mitochondria
function
synapses
implications
mitochondrial
dysfunctions
transmission.
First,
importance
distribution
motility
for
maintenance
strengthening
dendritic
spines,
but
also
new
spines/synapses
formation
presented.
Secondly,
major
functions
as
energy
supplier
calcium
buffer
organelles
considered
possible
explanation
their
essential
neuronal
processes.
Thirdly,
effects
potentiation
gene
expression
discussed.
And
finally,
relation
between
age-related
alterations
considered.
It
appears
that
memory
loss
neurodegeneration
during
aging
related
(dys)function.
Although,
it
clear
plasticity,
further
studies
indicated
scrutinize
intracellular
molecular
regulate
