Research Progress on the Structure and Function, Immune Escape Mechanism, Antiviral Drug Development Methods, and Clinical Use of SARS-CoV-2 Mpro
Molecules,
Год журнала:
2025,
Номер
30(2), С. 351 - 351
Опубликована: Янв. 16, 2025
The
three-year
COVID-19
pandemic
‘has’
caused
a
wide
range
of
medical,
social,
political,
and
financial
implications.
Since
the
end
2020,
various
mutations
variations
in
SARS-CoV-2
strains,
along
with
immune
escape
phenomenon,
have
emerged.
There
is
an
urgent
need
to
identify
relatively
stable
target
for
development
universal
vaccines
drugs
that
can
effectively
combat
both
strains
their
mutants.
Currently,
main
focus
treating
lies
disrupting
virus’s
life
cycle.
protease
(Mpro)
closely
associated
virus
replication
maturation
plays
crucial
role
early
stages
infection.
Consequently,
it
has
become
important
SARS-CoV-2-specific
drugs.
This
review
summarizes
recent
research
progress
on
novel
coronavirus’s
proteases,
including
pivotal
Mpro
cycle,
structure
catalytic
mechanism
Mpro,
self-maturation
escape,
current
methods
developing
antiviral
targeting
key
successfully
entered
clinical
trials.
aim
provide
researchers
involved
systematic
comprehensive
information.
Язык: Английский
The Efficiency of High-Throughput Screening (HTS) and in-silico data analysis during medical emergencies: identification of effective antiviral 3CLpro inhibitors.
Antiviral Research,
Год журнала:
2025,
Номер
unknown, С. 106119 - 106119
Опубликована: Фев. 1, 2025
Язык: Английский
Traditional Chinese medicine as a promising choice for future control of PEDV
Virus Research,
Год журнала:
2025,
Номер
unknown, С. 199572 - 199572
Опубликована: Апрель 1, 2025
Porcine
epidemic
diarrhea
virus
(PEDV)
is
the
major
agent
of
recent
outbreaks
in
piglets,
which
has
caused
huge
economic
losses
to
global
swine
industry.
Since
traditional
vaccine
strategies
cannot
provide
complete
protection
for
development
safe,
effective,
and
economical
antiviral
drugs
urgently
needed.
For
many
years,
Chinese
medicines
(TCMs)
have
been
broadly
applied
viral
infectious
diseases,
exhibiting
advantages
such
as
abundant
resources,
lower
toxicity,
minimal
drug
resistance.
Many
herbal
monomers,
single
extracts
derived
from
these
drugs,
recipes
exhibit
significant
anti-PEDV
effects
vitro
and/or
vivo
by
targeting
multiple
sites
perspectives,
including
inhibition
life
cycle,
anti-inflammation
effects,
enhancement
host
immune
response,
modulation
reactive
oxygen
species,
apoptosis.
However,
date,
no
review
published
on
TCM.
Therefore,
this
summarizes
current
control
PEDV
systematically
analyses
research
progress
TCMs
against
PEDV.
Furthermore,
future
directions
integration
nanotechnology
artificial
intelligence
with
are
also
discussed.
This
will
a
valuable
reference
studies
research.
Язык: Английский