Research Progress on the Structure and Function, Immune Escape Mechanism, Antiviral Drug Development Methods, and Clinical Use of SARS-CoV-2 Mpro

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 351 - 351

Published: Jan. 16, 2025

The three-year COVID-19 pandemic ‘has’ caused a wide range of medical, social, political, and financial implications. Since the end 2020, various mutations variations in SARS-CoV-2 strains, along with immune escape phenomenon, have emerged. There is an urgent need to identify relatively stable target for development universal vaccines drugs that can effectively combat both strains their mutants. Currently, main focus treating lies disrupting virus’s life cycle. protease (Mpro) closely associated virus replication maturation plays crucial role early stages infection. Consequently, it has become important SARS-CoV-2-specific drugs. This review summarizes recent research progress on novel coronavirus’s proteases, including pivotal Mpro cycle, structure catalytic mechanism Mpro, self-maturation escape, current methods developing antiviral targeting key successfully entered clinical trials. aim provide researchers involved systematic comprehensive information.

Language: Английский

The Efficiency of High-Throughput Screening (HTS) and in-silico data analysis during medical emergencies: identification of effective antiviral 3CLpro inhibitors.

Antiviral Research, Journal Year: 2025, Volume and Issue: unknown, P. 106119 - 106119

Published: Feb. 1, 2025

Language: Английский

Traditional Chinese medicine as a promising choice for future control of PEDV

Virus Research, Journal Year: 2025, Volume and Issue: unknown, P. 199572 - 199572

Published: April 1, 2025

Porcine epidemic diarrhea virus (PEDV) is the major agent of recent outbreaks in piglets, which has caused huge economic losses to global swine industry. Since traditional vaccine strategies cannot provide complete protection for development safe, effective, and economical antiviral drugs urgently needed. For many years, Chinese medicines (TCMs) have been broadly applied viral infectious diseases, exhibiting advantages such as abundant resources, lower toxicity, minimal drug resistance. Many herbal monomers, single extracts derived from these drugs, recipes exhibit significant anti-PEDV effects vitro and/or vivo by targeting multiple sites perspectives, including inhibition life cycle, anti-inflammation effects, enhancement host immune response, modulation reactive oxygen species, apoptosis. However, date, no review published on TCM. Therefore, this summarizes current control PEDV systematically analyses research progress TCMs against PEDV. Furthermore, future directions integration nanotechnology artificial intelligence with are also discussed. This will a valuable reference studies research.

Language: Английский