International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7616 - 7616
Опубликована: Июль 11, 2024
To
date,
more
than
400
types
of
human
papillomavirus
(HPV)
have
been
identified.
Despite
the
creation
effective
prophylactic
vaccines
against
most
common
genital
HPVs,
viruses
remain
among
prevalent
pathogens
found
in
humans.
According
to
WHO
data,
they
are
cause
5%
all
cancers.
Even
frequent
persistent
and
recurrent
benign
lesions
such
as
warts.
HPVs
resistant
many
disinfectants
relatively
unsusceptible
external
conditions.
There
is
still
no
drug
available
inhibit
viral
replication,
treatment
based
on
removing
or
stimulating
host
immune
system.
This
paper
presents
systematics
HPV
differences
structure
between
different
genetic
types,
lineages,
sublineages,
literature
GenBank
data.
We
also
present
pathogenesis
diseases
caused
by
HPV,
with
a
special
focus
role
played
E6,
E7,
other
proteins
development
cancerous
lesions.
discuss
further
prospects
for
infections,
including,
others,
substances
that
block
entry
into
cells,
inhibitors
early
proteins,
some
plant
origin
well
new
possibilities
therapeutic
vaccines.
Frontiers in Public Health,
Год журнала:
2021,
Номер
8
Опубликована: Янв. 20, 2021
Diagnosed
in
more
than
90%
of
cervical
cancers,
the
fourth
deadliest
cancer
women,
human
papillomavirus
(HPV)
is
currently
most
common
pathogen
responsible
for
female
cancers.
Moreover,
HPV
infection
associated
with
many
other
diseases,
including
cutaneous
and
anogenital
warts,
genital
upper
aerodigestive
tract
The
incidence
prevalence
these
pathologies
vary
considerably
depending
on
factors
genotype,
regional
conditions,
study
population,
anatomical
site
sampled.
Recently,
features
cervicovaginal
microbiota
are
found
to
be
HPV-related
presenting
a
novel
approach
identify
high-risk
women
through
both
blood
samples.
Overall,
repartition
data
show
that
related
diseases
prevalent
developing
countries.
available
(2-,
4-,
9-valent)
vaccines
based
virus-like
particles,
despite
their
proven
effectiveness
safety,
present
some
limitations
terms
system
development
cost,
transport
cold
chain,
oncogenic
variants.
In
addition,
vaccination
programs
face
challenges,
leading
considerable
burden
diseases.
Therefore,
even
though
new
(9-valent)
vaccine
seems
promising,
next-generation
as
well
awareness
budget
reinforcements
immunization
needed.
Nature Communications,
Год журнала:
2018,
Номер
9(1)
Опубликована: Окт. 10, 2018
Abstract
Patients
with
densely
innervated
tumors
suffer
increased
metastasis
and
decreased
survival
as
compared
to
those
less
tumors.
We
hypothesize
that
in
some
tumors,
nerves
are
acquired
by
a
tumor-induced
process,
called
axonogenesis.
Here,
we
use
PC12
cells
an
vitro
neuronal
model,
human
tumor
samples
murine
vivo
models
test
this
hypothesis.
When
appropriately
stimulated,
extend
processes,
neurites.
show
patient
release
vesicles,
exosomes,
which
induce
neurite
outgrowth.
Using
cancer
mouse
compromised
exosome
than
controls.
Moreover,
pharmacological
blockade
of
similarly
attenuates
innervation.
characterize
these
sensory
nature
demonstrate
axonogenesis
is
potentiated
the
exosome-packaged
axonal
guidance
molecule,
EphrinB1.
These
findings
indicate
released
exosomes
innervation
containing
EphrinB1
potentiate
activity.
Journal of General Virology,
Год журнала:
2021,
Номер
102(3)
Опубликована: Янв. 11, 2021
Persistent
infection
with
high-risk
human
papillomaviruses
(HR-HPVs)
is
the
causal
factor
in
over
99
%
of
cervical
cancer
cases,
and
a
significant
proportion
oropharyngeal
anogenital
cancers.
The
key
drivers
HPV-mediated
transformation
are
oncoproteins
E5,
E6
E7.
Together,
they
act
to
prolong
cell-cycle
progression,
delay
differentiation
inhibit
apoptosis
host
keratinocyte
cell
order
generate
an
environment
permissive
for
viral
replication.
also
have
roles
mediating
evasion
immune
response,
enabling
persist.
Moreover,
prolonged
within
cellular
established
by
HR-HPV
can
lead
acquisition
genetic
mutations,
eventually
culminating
malignancy.
In
this
review,
we
outline
many
ways
which
manipulate
environment,
focusing
on
how
these
activities
contribute
carcinogenesis.
Frontiers in Immunology,
Год журнала:
2022,
Номер
12
Опубликована: Янв. 27, 2022
Human
papillomavirus
(HPV)
is
the
most
common
sexually
transmitted
agent
worldwide.
Early
prevention
with
HPV
vaccination
a
safe
and
effective
method
against
this
disease.
vaccines
provided
more
protection
several
oncogenic
strains.
Three
prophylactic
have
been
approved
to
target
high-risk
types
protect
HPV-related
disorders.
These
existing
are
based
on
recombinant
DNA
technology
purified
L1
protein
that
assembled
form
empty
shells.
The
highly
immunogenic
can
induce
production
of
specific
neutralizing
antibodies.
However,
therapeutic
different
from
these
vaccines.
They
induced
cell-mediated
immunity
transformed
cells,
instead
second
generation
vaccines,
made
alternative
viral
components
using
cost-effective
strategies,
undergoing
clinical
evaluation.
purpose
review
provide
complete
up-to-date
efficiency
each
them
for
readers.
Pathogens,
Год журнала:
2023,
Номер
12(2), С. 298 - 298
Опубликована: Фев. 11, 2023
Cervical
cancer
is
the
fourth
most
common
malignancy
in
females
worldwide,
and
a
leading
cause
of
death
United
Kingdom
(UK).
The
human
papillomavirus
(HPV)
strongest
risk
factor
for
developing
cervical
intraepithelial
neoplasia
cancer.
Across
UK,
national
HPV
immunisation
programme,
introduced
2008,
has
been
successful
protecting
against
HPV-related
infections.
Furthermore,
National
Health
Service
(NHS)
implemented
cytology-based
screening
service
to
all
aged
25
64,
which
observed
decline
incidence.
In
there
an
overall
age-appropriate
coverage
since
April
2010.
2019,
COVID-19
pandemic
disrupted
NHS
programmes,
6.8%
decreased
uptake
from
previous
year.
Engagement
with
also
associated
social
deprivation.
England,
incidence
rates
were
reported
be
65%
higher
deprived
areas
compared
least,
lifestyle
factors
such
as
cigarette
consumption
contributing
21%
cases.
this
article,
we
provide
update
on
epidemiology
cancer,
pathogenesis
transmission,
along
current
prevention
programmes
within
NHS.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2022,
Номер
12
Опубликована: Июль 4, 2022
Persistent
human
papillomavirus
(HPV)
infection
is
recognized
as
the
main
cause
of
cervical
cancer
and
other
malignant
cancers.
Although
early
detection
treatment
can
be
achieved
by
effective
HPV
screening
methods
surgical
procedures,
disease
load
has
not
been
adequately
mitigated
yet,
especially
in
underdeveloped
areas.
Vaccine,
being
regarded
a
more
solution,
expected
to
prevent
virus
consequent
diseases
phases
both
prevention
treatment.
Currently,
there
are
three
licensed
prophylactic
vaccines
for
L1-VLPs,
namely
bivalent,
quadrivalent
nonavalent
vaccine.
About
90%
infections
have
effectively
prevented
with
implementation
worldwide.
However,
no
significant
therapeutic
effect
observed
on
already
existed
lesions.
Therapeutic
vaccine
designed
oncoprotein
E6/E7
activates
cellular
immunity
rather
than
focuses
neutralizing
antibodies,
which
considered
an
ideal
immune
method
eliminate
infection.
In
this
review,
we
elaborate
classification,
mechanism,
clinical
effects
treatment,
order
make
improvements
current
situation
provoking
new
ideas.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Янв. 24, 2025
Abstract
Human
papillomaviruses,
particularly
high-risk
human
have
been
universally
considered
to
be
associated
with
the
oncogenesis
and
progression
of
various
cancers.
The
genome
papillomaviruses
is
circular,
double-stranded
DNA
that
encodes
early
late
proteins.
Each
proteins
crucial
significance
in
infecting
epithelium
host
cells
persistently
supporting
viral
integrating
into
cells.
Notably,
E6
E7
proteins,
classified
as
oncoproteins,
trigger
incidence
cancers
by
fostering
cell
proliferation,
hindering
apoptosis,
evading
immune
surveillance,
promoting
invasion,
disrupting
balance
cellular
metabolism.
Therefore,
targeting
decoding
molecular
mechanisms
which
drive
carcinogenesis
are
great
necessity
better
treat
papillomaviruses-related
applied
clinically
different
facets
papillomavirus-related
cancers,
including
prevention,
screening,
diagnosis,
treatment,
prognosis.
Several
types
prophylactic
vaccines
publicly
utilized
worldwide
greatly
decreased
occurrence
benefited
numerous
people.
Although
therapeutic
developed
tested
clinically,
none
them
officially
approved
date.
Enhancing
efficacy
searching
for
innovative
technologies
remain
critical
challenges
warrant
continuous
research
attention
future.
