Exploring the barriers to cervical screening and perspectives on new self-sampling methods amongst under-served groups DOI Creative Commons

Stephanie Gillibrand,

Helen Gibson, Kelly Howells

и другие.

BMC Health Services Research, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 15, 2025

Abstract Background Cervical screening rates have fallen in recent years the UK, representing a health inequity for some under-served groups. Self-sampling alternatives to cervical may be useful where certain barriers prohibit access routine screening. However, there is limited evidence on whether self-sampling methods address known and subsequently increase uptake amongst under-screened Addressing this research gap, study aims understand experiences during attending groups and; explore views of individuals eligible towards (vaginal swabbing urine sampling) as alternative how existing Methods We draw three integrated theoretical frameworks (access primary care services, intersectional feminist perspectives) examine participants’ toward methods. undertook qualitative data collection (interviews focus groups) with 46 participants, facilitated by collaborations VCSE sector which successfully enhanced reach communities. Results Known persist participant groups, but we also find numerous examples good practice needs were met throughout process. Both positive negative tend centre around healthcare professionals, centring use speculum. swab collection) positively received through proponents choice – between method location (which dovetailed convenience) leading greater empowerment. The removal speculum lack invasive examination professional was received. Conclusions Whilst remain are prevalent. Such should implemented more widely ensure consistency patient experience better introduction alongside traditional reduce screening, boost only if they appropriate information sufficient communication. Failure implement without these considerations threaten undermine identified important benefits

Язык: Английский

Epidemiology of HPV-associated cancers past, present and future: towards prevention and elimination DOI
Talía Malagón, Eduardo L. Franco, Romina A. Tejada

и другие.

Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(7), С. 522 - 538

Опубликована: Май 17, 2024

Язык: Английский

Процитировано

37
Effect of the HPV vaccination programme on incidence of cervical cancer and grade 3 cervical intraepithelial neoplasia by socioeconomic deprivation in England: population based observational study DOI Creative Commons
Milena Falcaro, Kate Soldan,

B Ndlela

и другие.

BMJ, Год журнала: 2024, Номер unknown, С. e077341 - e077341

Опубликована: Май 15, 2024

Abstract Objectives To replicate previous analyses on the effectiveness of English human papillomavirus (HPV) vaccination programme incidence cervical cancer and grade 3 intraepithelial neoplasia (CIN3) using 12 additional months follow-up, to investigate across levels socioeconomic deprivation. Design Observational study. Setting England, UK. Participants Women aged 20-64 years resident in England between January 2006 June 2020 including 29 968 with a diagnosis 335 228 CIN3. In HPV was introduced nationally 2008 offered routinely girls 12-13 years, catch-up campaigns during 2008-10 targeting older teenagers <19 years. Main outcome measures Incidence invasive Results women received CIN3 1 30 2020. birth cohort at age adjusted standardised rates follow-up (1 July 2019 2020) were, respectively, 83.9% (95% confidence interval (CI) 63.8% 92.8%) 94.3% (92.6% 95.7%) lower than reference who were never vaccination. By mid-2020, had prevented an estimated 687 CI 556 819) cancers 23 192 (22 163 24 220) CIN3s. The highest remained among living most deprived areas, but large effect all five vaccination, decreased more those from least areas (reductions 40.6% v 29.6% 72.8% 67.7% for 16-18 14-16, respectively). strong downward gradient high low deprivation unvaccinated group no longer present vaccine. Conclusions national previously seen continued follow-up. associated substantially reduced groups, especially routine

Язык: Английский

Процитировано

35
Metasurface Based Surface Plasmon Resonance (SPR) Biosensor for Cervical Cancer Detection with Behaviour Prediction using Machine Learning Optimization Based on Support Vector Regression DOI
Jacob Wekalao,

Mouleeswaran Singanallur Kumaresan,

Srinivasan Mallan

и другие.

Plasmonics, Год журнала: 2024, Номер unknown

Опубликована: Окт. 28, 2024

Язык: Английский

Процитировано

21
The Role of Chronic Inflammation in Pediatric Cancer DOI Open Access

Christine Mella,

Panogiotis Tsarouhas,

Maximillian Brockwell

и другие.

Cancers, Год журнала: 2025, Номер 17(1), С. 154 - 154

Опубликована: Янв. 6, 2025

Inflammation plays a crucial role in wound healing and the host immune response following pathogenic invasion. However, unresolved chronic inflammation can result tissue fibrosis genetic alterations that contribute to pathogenesis of human diseases such as cancer. Recent scientific advancements exploring underlying mechanisms malignant cellular transformations cancer progression have exposed significant disparities between pediatric adult-onset cancers. For instance, cancers tend lower mutational burdens arise actively developing tissues, where cell-cycle dysregulation leads gene, chromosomal, fusion gene development not seen counterparts. As such, findings adult cannot be directly applied cancers, unique mutations inherent etiologies remain poorly understood. Here, we review processes chromosomal instability, tumor microenvironment, tumorigenesis transformation explore current therapeutic interventions maintain and/or restore inflammatory homeostasis.

Язык: Английский

Процитировано

3
Human Papillomavirus Infections and the Role Played by Cervical and Cervico-Vaginal Microbiota—Evidence from Next-Generation Sequencing Studies DOI Open Access
Maria Głowienka, Katarzyna Bagińska, Sebastian Szubert

и другие.

Cancers, Год журнала: 2024, Номер 16(2), С. 399 - 399

Опубликована: Янв. 17, 2024

This comprehensive review encompasses studies examining changes in the cervical and cervico-vaginal microbiota (CM CVM) relation to human papillomavirus (HPV) using next-generation sequencing (NGS) technology. HPV infection remains a prominent global health concern, with spectrum of manifestations, from benign lesions life-threatening cancers. The CM CVM, unique collection microorganisms inhabiting cervix/vagina, has emerged as critical player health. Recent research indicated that disruptions characterized by decrease Lactobacillus overgrowth other bacteria, might increase risk persistence progression abnormalities. alteration or CVM been linked higher likelihood dysplasia. NGS technology revolutionized study microbiome, providing insights into microbial diversity, dynamics, taxonomic classifications. Bacterial 16S rRNA gene sequencing, proven invaluable characterizing shedding light on its role infections paving way for more tailored strategies combat diseases. NGS-based offer personalized an individual’s microbiome. knowledge holds promise development novel diagnostic tools, targeted therapies, preventive interventions cervix-related conditions, including cancer.

Язык: Английский

Процитировано

13
Long noncoding RNA MALAT-1: A versatile regulator in cancer progression, metastasis, immunity, and therapeutic resistance DOI Creative Commons

Dexin Xu,

Wenhai Wang, Duo Wang

и другие.

Non-coding RNA Research, Год журнала: 2024, Номер 9(2), С. 388 - 406

Опубликована: Фев. 1, 2024

Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides that do not code for proteins but have been linked to cancer development and metastasis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) influences crucial hallmarks through intricate molecular mechanisms, including proliferation, invasion, angiogenesis, apoptosis, the epithelial-mesenchymal transition (EMT). The current article highlights involvement of MALAT-1 in drug resistance, making it a potential target overcome chemotherapy refractoriness. It discusses impact on immunomodulatory molecules, such as major histocompatibility complex (MHC) PD-L1, leading immune evasion hindering anti-tumor responses. also plays significant role immunology by regulating diverse cell populations. In summary, is versatile regulator, influencing tumorigenesis, chemoresistance, immunotherapy Understanding its precise mechanisms developing targeted therapies, therapeutic strategies targeting show promise improving treatment outcomes. However, further research needed fully uncover biology translate these findings into clinical applications.

Язык: Английский

Процитировано

12
CausalCervixNet: convolutional neural networks with causal insight (CICNN) in cervical cancer cell classification—leveraging deep learning models for enhanced diagnostic accuracy DOI Creative Commons

Zahra Taghados,

Zohreh Azimifar,

Malihezaman Monsefi

и другие.

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 3, 2025

Язык: Английский

Процитировано

1
In silico exploration of novel EGFR-targeting compounds: integrative molecular modeling, docking, pharmacokinetics, and MD simulations for advancing anti-cervical cancer therapeutics DOI Creative Commons
A Isa,

Adamu Uzairu,

Umar Meleh Umar

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 1, 2025

Cervical cancer continues to pose a significant health challenge, especially in resource-limited settings, highlighting the need for development of novel therapeutic agents. This study investigates potential 2,4-diphenyl indenol [1,2-b] pyridinol derivatives as inhibitors targeting epidermal growth factor receptor (EGFR) through computational drug discovery methods. A genetic algorithm-multiple linear regression (GA-MLR) model was created, achieving strong predictive accuracy with R² = 0.9243, Q² 0.8957, CCC 0.9021, and MAE 0.034. Molecular docking studies indicated that ligand 57 displayed highest binding affinity -29.2313 kcal/mol, followed by ligands 111 (-29.1459 kcal/mol) 110 (-29.9082 kcal/mol), all which stabilize key EGFR residues. dynamics (MD) simulations confirmed stability 111, showing an improved free energy -18.2235 kcal/mol. Additionally, pharmacokinetic analysis further validated their favorable ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) properties, supporting drug-like candidates. These findings establish foundation EGFR-targeted therapies cervical cancer.

Язык: Английский

Процитировано

1
Bacterial Species from Vaginal Microbiota Differently Affect the Production of the E6 and E7 Oncoproteins and of p53 and p-Rb Oncosuppressors in HPV16-Infected Cells DOI Open Access
Sabrina Nicolò, Alberto Antonelli, Michele Tanturli

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7173 - 7173

Опубликована: Апрель 12, 2023

Vaginal dysbiosis is characterized by a decrease in the relative abundance of Lactobacillus species favor other species. This condition facilitates infections sexually transmitted pathogens including high risk (HR)-human papilloma viruses (HPVs) involved development cervical cancer. Some vaginal bacteria contribute to neoplastic progression inducing chronic inflammation and directly activating molecular pathways carcinogenesis. In this study, SiHa cells, an HPV-16-transformed epithelial cell line, were exposed different representative microbial communities. The expression HPV oncogenes E6 E7 production oncoproteins was evaluated. results showed that crispatus gasseri modulated basal genes cells oncoproteins. had contrasting effects on E6/E7 gene protein production. increased strains Gardnerella vaginalis and, lesser extent, Megasphaera micronuciformis. contrast, Prevotella bivia decreased protein. A amount p53 pRb found cultures with M. micronuciformis, accordingly, same cultures, higher percentage progressed S-phase cycle compared untreated or Lactobacillus-stimulated cultures. These data confirm L. represents most protective component microbiota against HR-HPV infected while micronuciformis G. may interfere oncogenic process, maintaining viral

Язык: Английский

Процитировано

17
Epidemiology of cervical cancer in Iran in 2016: A nationwide study of incidence and regional variation DOI Creative Commons
Alireza Anjam Majoumerd, Saeed Hosseini,

Seyyed Mohammad Hossein Hosseini

и другие.

Cancer Reports, Год журнала: 2024, Номер 7(2)

Опубликована: Янв. 12, 2024

Cervical cancer is a common, and fatal in women worldwide. This the fourth most common after breast, colorectal, lung cancer.

Язык: Английский

Процитировано

6