BMC Cardiovascular Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 20, 2024
Triglyceride-glucose
(TyG)
index,
which
is
a
valuable
measure
of
insulin
resistance,
has
been
found
to
have
predictive
value
for
cardiovascular
disease
(CVD).
However,
its
relationship
with
CVD
among
individuals
chronic
kidney
(CKD)
not
thoroughly
investigated.
This
study
focused
on
examining
the
TyG
index
and
CKD
patients
in
United
States.
3507
eligible
participants
from
National
Health
Nutrition
Examination
Survey
(2003–2018)
were
surveyed
this
study.
Methods
such
as
multivariable
logistic
regression
analysis
smooth
curve
fitting
employed
estimate
how
linked
populations.
Subgroup
interaction
analyses
conducted
order
figure
out
potential
moderating
effects
various
factors.
In
cross-sectional
based
population
CKD,
29.5%
also
had
CVD.
An
independent
positive
link
was
revealed
(OR
1.213,
95%
CI
1.059,
1.389).
association
nonlinear,
threshold
effect
observed
at
8.98.
The
results
subgroup
suggested
that
relationships
differed
according
stage:
1.048,
0.857,
1.282)
stages
1–2;
1.267,
1.030–1.560)
stage
3;
2.131,
1.224–3.709)
4–5.
Interaction
further
stage.
Additionally,
specific
types,
only
coronary
heart
(CHD)
significant
1.617,
1.123,
2.327).
identified
be
independently
positively
related
likelihood
CVD,
specifically
populations
an
eGFR
<
60
mL/min/1.73
m².
effect.
highlight
tool
screening
risk
assessment
suffering
warranting
investigation.
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 22, 2025
Chronic
heart
failure
(CHF)
is
a
complex
cardiovascular
disease
caused
by
different
pathological
mechanisms.
Modern
medicine
has
made
advancements
in
CHF
treatment;
however,
there
are
still
many
challenges.
Ershen
Zhenwu
Decoction
(ESZWD)
Xin'an
that
been
clinically
applied
for
years
and
had
good
efficacy
against
CHF;
its
underlying
mechanisms
remain
undetermined.
Therefore,
this
study
aims
to
investigate
the
primary
molecular
of
ESZWD
treatment
elucidate
multi-target
multi-level
mode
action.
The
aim
was
main
This
employed
network
pharmacology
approach
analyze
components
core
targets.
Furthermore,
targets
were
predicted
develop
protein-protein
interaction
(PPI)
perform
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
analyses.
Moreover,
docking
carried
out
validate
binding
between
active
ingredients
key
For
vitro
studies,
myocardial
cell
injury
models
employed,
immunofluorescence,
RT-qPCR,
Western
blot,
flow
cytometry
critical
relevant
signaling
pathways
specific
regulatory
Network
identified
437
34
major
components.
Of
these,
216
drug-disease
intersection
identified.
PPI
analysis
following
targets:
STAT3,
HSP90AA1,
MAPK8,
NFKB1,
HIF1A,
MMP9,
PTGS2,
BCL2L1,
TLR4,
ESR1.
GO
revealed
these
associated
with
exogenous
stimuli
responses,
phosphorylation
regulation,
inflammatory
response,
protein
tyrosine
kinase
activity.
KEGG
showed
predominantly
impacts
cancer,
apoptosis
pathways,
c-Jun
N-terminal
kinase/mitogen-activated
(JNK/MAPK)-regulated
being
pathway.
In
analyses
effectively
inhibited
JNK
activation,
modulated
MAPK
signaling,
downregulated
pro-apoptotic
gene
expression,
significantly
reduced
cardiomyocyte
rates,
thus
validating
findings.
Our
shows
paeoniflorin,
acetylaconitine,
cryptotanshinone
bind
proteins
JNK/MAPK
validation
confirms
drug
serum
from
regulates
pathway,
supporting
therapeutic
potential
CHF.
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(5), С. 308 - 308
Опубликована: Апрель 27, 2025
Fraxin
is
a
bioactive
compound
derived
from
Cortex
Fraxini.
It
known
for
its
diverse
biological
activities
and
numerous
benefits,
including
anti-inflammatory,
antioxidant,
analgesic,
antimicrobial,
antiviral,
immunomodulatory
effects.
Despite
growing
interest
in
natural
compounds
cardiovascular
diseases
Fraxin’s
atheroprotective
properties
molecular
targets
have
not
yet
been
fully
elucidated.
To
address
this
gap,
our
research
employed
an
integrated
approach
combining
network
pharmacology,
docking
simulations,
vitro
validation
to
systematically
unravel
therapeutic
mechanisms
against
atherosclerosis
(AS).
The
results
showed
that
84
potential
AS
were
predicted
through
public
databases,
the
key
target
TLR4
was
identified
by
protein–protein
interaction
analysis.
GO
enrichment
KEGG
pathway
analysis
revealed
these
significantly
enriched
PI3K-Akt
oxidative
stress
responses
pathways.
Subsequently
conducted
studies
validated
modulates
TLR4/PI3K/Akt
signaling
suppress
reactive
oxygen
species
generation
downregulate
pro-inflammatory
cytokines
Il1b,
Il6,
Tnf
thereby
slowing
atherosclerotic
disease
advancement.
This
investigation
methodically
delineates
underlying
management,
establishing
scientific
foundation
translation
into
clinical
practice.
Journal of Clinical Ultrasound,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 10, 2025
ABSTRACT
Objective
To
explore
the
association
of
transforming
growth
factor
β1
(TGF‐β1)
with
left
ventricular
geometry
(LVG)
and
function
(LVF)
in
cases
having
essential
hypertension.
Methods
This
retrospective
study
213
hypertension,
according
to
echocardiogram
measurements,
were
split
into
normal
(NG),
concentric
remodeling
(CR),
eccentric
hypertrophy
(EH),
(CH)
groups.
General
clinical
data
each
patient
was
analyzed
office
blood
pressure
measurements
performed.
Detection
biochemistry
serum
TGF‐β1
content
conducted.
The
LVG
LVF
parameters
assessed.
Results
In
contrast
NG
CR
groups,
concentration
higher
EH
CH
it
most
pronounced
group.
positively
linked
E/e′
(
r
=
0.506,
p
<
0.001),
whereas
global
longitudinal
strain
(GLS)
−0.447,
0.001)
negatively
correlated.
Moreover,
levels
independently
CH.
Conclusion
associated
abnormal
indicating
that
may
induce
abnormalities.
BMC Cardiovascular Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 20, 2024
Triglyceride-glucose
(TyG)
index,
which
is
a
valuable
measure
of
insulin
resistance,
has
been
found
to
have
predictive
value
for
cardiovascular
disease
(CVD).
However,
its
relationship
with
CVD
among
individuals
chronic
kidney
(CKD)
not
thoroughly
investigated.
This
study
focused
on
examining
the
TyG
index
and
CKD
patients
in
United
States.
3507
eligible
participants
from
National
Health
Nutrition
Examination
Survey
(2003–2018)
were
surveyed
this
study.
Methods
such
as
multivariable
logistic
regression
analysis
smooth
curve
fitting
employed
estimate
how
linked
populations.
Subgroup
interaction
analyses
conducted
order
figure
out
potential
moderating
effects
various
factors.
In
cross-sectional
based
population
CKD,
29.5%
also
had
CVD.
An
independent
positive
link
was
revealed
(OR
1.213,
95%
CI
1.059,
1.389).
association
nonlinear,
threshold
effect
observed
at
8.98.
The
results
subgroup
suggested
that
relationships
differed
according
stage:
1.048,
0.857,
1.282)
stages
1–2;
1.267,
1.030–1.560)
stage
3;
2.131,
1.224–3.709)
4–5.
Interaction
further
stage.
Additionally,
specific
types,
only
coronary
heart
(CHD)
significant
1.617,
1.123,
2.327).
identified
be
independently
positively
related
likelihood
CVD,
specifically
populations
an
eGFR
<
60
mL/min/1.73
m².
effect.
highlight
tool
screening
risk
assessment
suffering
warranting
investigation.