Association between triglyceride-glucose index and cardiovascular disease in US adults with chronic kidney disease: a population-based study DOI Creative Commons
Lijia Liu, Hui–Chuan Sun,

Lan Yi

и другие.

BMC Cardiovascular Disorders, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 20, 2024

Triglyceride-glucose (TyG) index, which is a valuable measure of insulin resistance, has been found to have predictive value for cardiovascular disease (CVD). However, its relationship with CVD among individuals chronic kidney (CKD) not thoroughly investigated. This study focused on examining the TyG index and CKD patients in United States. 3507 eligible participants from National Health Nutrition Examination Survey (2003–2018) were surveyed this study. Methods such as multivariable logistic regression analysis smooth curve fitting employed estimate how linked populations. Subgroup interaction analyses conducted order figure out potential moderating effects various factors. In cross-sectional based population CKD, 29.5% also had CVD. An independent positive link was revealed (OR 1.213, 95% CI 1.059, 1.389). association nonlinear, threshold effect observed at 8.98. The results subgroup suggested that relationships differed according stage: 1.048, 0.857, 1.282) stages 1–2; 1.267, 1.030–1.560) stage 3; 2.131, 1.224–3.709) 4–5. Interaction further stage. Additionally, specific types, only coronary heart (CHD) significant 1.617, 1.123, 2.327). identified be independently positively related likelihood CVD, specifically populations an eGFR < 60 mL/min/1.73 m². effect. highlight tool screening risk assessment suffering warranting investigation.

Язык: Английский

Mechanism of Ershen Zhenwu Decoction in ameliorating chronic heart failure via JNK/MAPK-regulated apoptosis: insights from network pharmacology and experimental validation DOI Creative Commons
Yulong Liu, Xinyue Wang,

Maomao Zhang

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 22, 2025

Chronic heart failure (CHF) is a complex cardiovascular disease caused by different pathological mechanisms. Modern medicine has made advancements in CHF treatment; however, there are still many challenges. Ershen Zhenwu Decoction (ESZWD) Xin'an that been clinically applied for years and had good efficacy against CHF; its underlying mechanisms remain undetermined. Therefore, this study aims to investigate the primary molecular of ESZWD treatment elucidate multi-target multi-level mode action. The aim was main This employed network pharmacology approach analyze components core targets. Furthermore, targets were predicted develop protein-protein interaction (PPI) perform Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses. Moreover, docking carried out validate binding between active ingredients key For vitro studies, myocardial cell injury models employed, immunofluorescence, RT-qPCR, Western blot, flow cytometry critical relevant signaling pathways specific regulatory Network identified 437 34 major components. Of these, 216 drug-disease intersection identified. PPI analysis following targets: STAT3, HSP90AA1, MAPK8, NFKB1, HIF1A, MMP9, PTGS2, BCL2L1, TLR4, ESR1. GO revealed these associated with exogenous stimuli responses, phosphorylation regulation, inflammatory response, protein tyrosine kinase activity. KEGG showed predominantly impacts cancer, apoptosis pathways, c-Jun N-terminal kinase/mitogen-activated (JNK/MAPK)-regulated being pathway. In analyses effectively inhibited JNK activation, modulated MAPK signaling, downregulated pro-apoptotic gene expression, significantly reduced cardiomyocyte rates, thus validating findings. Our shows paeoniflorin, acetylaconitine, cryptotanshinone bind proteins JNK/MAPK validation confirms drug serum from regulates pathway, supporting therapeutic potential CHF.

Язык: Английский

Процитировано

0
Fraxin Alleviates Atherosclerosis by Inhibiting Oxidative Stress and Inflammatory Responses via the TLR4/PI3K/Akt Pathway DOI Creative Commons
Yaru Wang,

Bailing Wei,

Mingyang Leng

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(5), С. 308 - 308

Опубликована: Апрель 27, 2025

Fraxin is a bioactive compound derived from Cortex Fraxini. It known for its diverse biological activities and numerous benefits, including anti-inflammatory, antioxidant, analgesic, antimicrobial, antiviral, immunomodulatory effects. Despite growing interest in natural compounds cardiovascular diseases Fraxin’s atheroprotective properties molecular targets have not yet been fully elucidated. To address this gap, our research employed an integrated approach combining network pharmacology, docking simulations, vitro validation to systematically unravel therapeutic mechanisms against atherosclerosis (AS). The results showed that 84 potential AS were predicted through public databases, the key target TLR4 was identified by protein–protein interaction analysis. GO enrichment KEGG pathway analysis revealed these significantly enriched PI3K-Akt oxidative stress responses pathways. Subsequently conducted studies validated modulates TLR4/PI3K/Akt signaling suppress reactive oxygen species generation downregulate pro-inflammatory cytokines Il1b, Il6, Tnf thereby slowing atherosclerotic disease advancement. This investigation methodically delineates underlying management, establishing scientific foundation translation into clinical practice.

Язык: Английский

Процитировано

0
Relationship Between TGF‐β1 and Left Ventricular Geometry and Function in Patients With Essential Hypertension DOI
Ran Hou,

Wen Shui,

Xueqing Xing

и другие.

Journal of Clinical Ultrasound, Год журнала: 2025, Номер unknown

Опубликована: Май 10, 2025

ABSTRACT Objective To explore the association of transforming growth factor β1 (TGF‐β1) with left ventricular geometry (LVG) and function (LVF) in cases having essential hypertension. Methods This retrospective study 213 hypertension, according to echocardiogram measurements, were split into normal (NG), concentric remodeling (CR), eccentric hypertrophy (EH), (CH) groups. General clinical data each patient was analyzed office blood pressure measurements performed. Detection biochemistry serum TGF‐β1 content conducted. The LVG LVF parameters assessed. Results In contrast NG CR groups, concentration higher EH CH it most pronounced group. positively linked E/e′ ( r = 0.506, p < 0.001), whereas global longitudinal strain (GLS) −0.447, 0.001) negatively correlated. Moreover, levels independently CH. Conclusion associated abnormal indicating that may induce abnormalities.

Язык: Английский

Процитировано

0
The critical role of platelets in venous thromboembolism: Pathogenesis, clinical status, and emerging therapeutic strategies DOI
Shuang Liu, Yan Shen, Jiayi Chen

и другие.

Blood Reviews, Год журнала: 2025, Номер unknown, С. 101302 - 101302

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Association between triglyceride-glucose index and cardiovascular disease in US adults with chronic kidney disease: a population-based study DOI Creative Commons
Lijia Liu, Hui–Chuan Sun,

Lan Yi

и другие.

BMC Cardiovascular Disorders, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 20, 2024

Triglyceride-glucose (TyG) index, which is a valuable measure of insulin resistance, has been found to have predictive value for cardiovascular disease (CVD). However, its relationship with CVD among individuals chronic kidney (CKD) not thoroughly investigated. This study focused on examining the TyG index and CKD patients in United States. 3507 eligible participants from National Health Nutrition Examination Survey (2003–2018) were surveyed this study. Methods such as multivariable logistic regression analysis smooth curve fitting employed estimate how linked populations. Subgroup interaction analyses conducted order figure out potential moderating effects various factors. In cross-sectional based population CKD, 29.5% also had CVD. An independent positive link was revealed (OR 1.213, 95% CI 1.059, 1.389). association nonlinear, threshold effect observed at 8.98. The results subgroup suggested that relationships differed according stage: 1.048, 0.857, 1.282) stages 1–2; 1.267, 1.030–1.560) stage 3; 2.131, 1.224–3.709) 4–5. Interaction further stage. Additionally, specific types, only coronary heart (CHD) significant 1.617, 1.123, 2.327). identified be independently positively related likelihood CVD, specifically populations an eGFR < 60 mL/min/1.73 m². effect. highlight tool screening risk assessment suffering warranting investigation.

Язык: Английский

Процитировано

1