Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 7, 2024
Introduction
and
objectives
Recent
studies
have
indicated
a
potential
association
of
hypertension
with
Hashimoto’s
thyroiditis
(HT)
other
autoimmune
diseases,
yet
the
impact
antihypertensive
drugs
on
HT
risk
is
not
well
understood.
Methods
We
employed
drug-target
Mendelian
randomization
approach
to
investigate
prolonged
9
classes
medications
susceptibility
in
European
Asian
populations.
Genetic
variants
close
or
within
genes
associated
drug
targets
systolic
blood
pressure
(SBP)
were
utilized
mimic
effects
medications.
focused
linked
lower
coronary
artery
disease
for
our
main
analysis.
gathered
genetic
data
SBP
from
comprehensive
genome-wide
available
groups.
For
supplementary
analysis,
we
used
expression
quantitative
trait
loci
(eQTLs)
related
target
as
proxies.
Results
Our
analysis
revealed
that
use
calcium
channel
blockers
(CCBs)
reduced
both
(OR
[95%
CI]:
0.96
[0.95
0.98]
per
1
mmHg
decrease
SBP;
p
=
3.51×10
-5
)
populations
0.28
[0.12,
0.66];
3.54×10
-3
).
Moreover,
genetically
mimicking
loop
diuretics
0.94
[0.91,
0.97];
3.57×10
thiazide
(0.98
[0.96,
0.99];
3.83×10
showed
significant
decreased
only
population.
These
outcomes
confirmed
when
eQTLs
represent
Conclusion
The
study
suggests
CCBs
could
potentially
reduce
different
Additional
research
needed
assess
feasibility
repurposing
prevention
HT.
Journal of Clinical Ultrasound,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 10, 2025
ABSTRACT
Objective
To
explore
the
association
of
transforming
growth
factor
β1
(TGF‐β1)
with
left
ventricular
geometry
(LVG)
and
function
(LVF)
in
cases
having
essential
hypertension.
Methods
This
retrospective
study
213
hypertension,
according
to
echocardiogram
measurements,
were
split
into
normal
(NG),
concentric
remodeling
(CR),
eccentric
hypertrophy
(EH),
(CH)
groups.
General
clinical
data
each
patient
was
analyzed
office
blood
pressure
measurements
performed.
Detection
biochemistry
serum
TGF‐β1
content
conducted.
The
LVG
LVF
parameters
assessed.
Results
In
contrast
NG
CR
groups,
concentration
higher
EH
CH
it
most
pronounced
group.
positively
linked
E/e′
(
r
=
0.506,
p
<
0.001),
whereas
global
longitudinal
strain
(GLS)
−0.447,
0.001)
negatively
correlated.
Moreover,
levels
independently
CH.
Conclusion
associated
abnormal
indicating
that
may
induce
abnormalities.
BMC Cardiovascular Disorders,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Dec. 20, 2024
Triglyceride-glucose
(TyG)
index,
which
is
a
valuable
measure
of
insulin
resistance,
has
been
found
to
have
predictive
value
for
cardiovascular
disease
(CVD).
However,
its
relationship
with
CVD
among
individuals
chronic
kidney
(CKD)
not
thoroughly
investigated.
This
study
focused
on
examining
the
TyG
index
and
CKD
patients
in
United
States.
3507
eligible
participants
from
National
Health
Nutrition
Examination
Survey
(2003–2018)
were
surveyed
this
study.
Methods
such
as
multivariable
logistic
regression
analysis
smooth
curve
fitting
employed
estimate
how
linked
populations.
Subgroup
interaction
analyses
conducted
order
figure
out
potential
moderating
effects
various
factors.
In
cross-sectional
based
population
CKD,
29.5%
also
had
CVD.
An
independent
positive
link
was
revealed
(OR
1.213,
95%
CI
1.059,
1.389).
association
nonlinear,
threshold
effect
observed
at
8.98.
The
results
subgroup
suggested
that
relationships
differed
according
stage:
1.048,
0.857,
1.282)
stages
1–2;
1.267,
1.030–1.560)
stage
3;
2.131,
1.224–3.709)
4–5.
Interaction
further
stage.
Additionally,
specific
types,
only
coronary
heart
(CHD)
significant
1.617,
1.123,
2.327).
identified
be
independently
positively
related
likelihood
CVD,
specifically
populations
an
eGFR
<
60
mL/min/1.73
m².
effect.
highlight
tool
screening
risk
assessment
suffering
warranting
investigation.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 7, 2024
Introduction
and
objectives
Recent
studies
have
indicated
a
potential
association
of
hypertension
with
Hashimoto’s
thyroiditis
(HT)
other
autoimmune
diseases,
yet
the
impact
antihypertensive
drugs
on
HT
risk
is
not
well
understood.
Methods
We
employed
drug-target
Mendelian
randomization
approach
to
investigate
prolonged
9
classes
medications
susceptibility
in
European
Asian
populations.
Genetic
variants
close
or
within
genes
associated
drug
targets
systolic
blood
pressure
(SBP)
were
utilized
mimic
effects
medications.
focused
linked
lower
coronary
artery
disease
for
our
main
analysis.
gathered
genetic
data
SBP
from
comprehensive
genome-wide
available
groups.
For
supplementary
analysis,
we
used
expression
quantitative
trait
loci
(eQTLs)
related
target
as
proxies.
Results
Our
analysis
revealed
that
use
calcium
channel
blockers
(CCBs)
reduced
both
(OR
[95%
CI]:
0.96
[0.95
0.98]
per
1
mmHg
decrease
SBP;
p
=
3.51×10
-5
)
populations
0.28
[0.12,
0.66];
3.54×10
-3
).
Moreover,
genetically
mimicking
loop
diuretics
0.94
[0.91,
0.97];
3.57×10
thiazide
(0.98
[0.96,
0.99];
3.83×10
showed
significant
decreased
only
population.
These
outcomes
confirmed
when
eQTLs
represent
Conclusion
The
study
suggests
CCBs
could
potentially
reduce
different
Additional
research
needed
assess
feasibility
repurposing
prevention
HT.
