Progress in Neurobiology, Год журнала: 2016, Номер 151, С. 101 - 138
Опубликована: Апрель 12, 2016
Язык: Английский
The Lancet, Год журнала: 2006, Номер 368(9533), С. 387 - 403
Опубликована: Июль 1, 2006
Язык: Английский
Процитировано
2872
FEBS Journal, Год журнала: 2006, Номер 273(13), С. 2813 - 2838
Опубликована: Июнь 15, 2006
Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring unicellular organisms, plants, fungi animals. In most vertebrates, including humans, melatonin synthesized primarily the pineal gland regulated by environmental light/dark cycle via suprachiasmatic nucleus. Pinealocytes function as 'neuroendocrine transducers' to secrete during dark phase of and, consequently, often called 'hormone darkness'. principally secreted at night centrally involved sleep regulation, well number other cyclical bodily activities. exclusively signaling 'time day' year' (hence considered help both clock calendar functions) all tissues thus be body's chronological pacemaker or 'Zeitgeber'. Synthesis also occurs areas body, retina, gastrointestinal tract, skin, bone marrow lymphocytes, from which it may influence physiological functions through paracrine signaling. has been extracted seeds leaves plants its concentration some this material several orders magnitude higher than night-time plasma value humans. participates diverse functions. addition timekeeping functions, an effective antioxidant scavenges free radicals up-regulates enzymes. It strong antiapoptotic function, effect exerts even ischemia. Melatonin's cytoprotective properties have practical implications treatment neurodegenerative diseases. immune-enhancing oncostatic properties. Its 'chronobiotic' shown treating various circadian rhythm disorders, such jet lag shift-work disorder. acting 'internal facilitator' promotes sleep, melatonin's sleep-facilitating found useful for insomnia symptoms elderly depressive patients. A recently introduced analog, agomelatine, efficient major disorder bipolar affective role 'photoperiodic molecule' seasonal reproduction established photoperiodic species, although regulatory humans remains under investigation. Taken together, evidence implicates broad range effects significant over many
Язык: Английский
Процитировано
846
Progress in Neurobiology, Год журнала: 2010, Номер 93(3), С. 350 - 384
Опубликована: Дек. 29, 2010
Язык: Английский
Процитировано
798
American Journal of Geriatric Psychiatry, Год журнала: 2013, Номер 21(12), С. 1190 - 1222
Опубликована: Ноя. 8, 2013
Язык: Английский
Процитировано
618
Journal of Neuropathology & Experimental Neurology, Год журнала: 2006, Номер 65(7), С. 631 - 641
Опубликована: Июль 1, 2006
Genetic and lifestyle-related risk factors for Alzheimer disease (AD) are associated with an increase in oxidative stress, suggesting that stress is involved at early stage of the pathologic cascade. Moreover, mechanistically chronologically other key features AD, namely, metabolic, mitochondrial, metal, cell-cycle abnormalities. Contrary to commonly held notion hallmarks AD signify etiology, several lines evidence now indicate aggregation amyloid-β tau a compensatory response underlying stress. Therefore, removal proteinaceous accumulations may treat epiphenomenon rather than actually enhance damage. Although some antioxidants have been shown reduce incidence magnitude effect be modified by individual such as genetic predisposition (e.g. apolipoprotein E genotype) habitual behaviors. Because caloric restriction, exercise, intellectual activity experimentally promote neuronal survival through enhancement endogenous antioxidant defenses, combination dietary regimen low total calorie rich nutrients maintaining physical activities ultimately prove one most efficacious strategies prevention.
Язык: Английский
Процитировано
600
Biochimica et Biophysica Acta (BBA) - Biomembranes, Год журнала: 2007, Номер 1768(8), С. 1976 - 1990
Опубликована: Фев. 10, 2007
Язык: Английский
Процитировано
586
Trends in Pharmacological Sciences, Год журнала: 2008, Номер 29(12), С. 609 - 615
Опубликована: Окт. 5, 2008
Язык: Английский
Процитировано
550
Nature reviews. Neuroscience, Год журнала: 2012, Номер 13(5), С. 325 - 335
Опубликована: Март 7, 2012
Язык: Английский
Процитировано
446
Molecular Neurobiology, Год журнала: 2014, Номер 53(1), С. 648 - 661
Опубликована: Дек. 16, 2014
Язык: Английский
Процитировано
412
Journal of Pineal Research, Год журнала: 2011, Номер 51(1), С. 17 - 43
Опубликована: Апрель 4, 2011
Abstract: The human pineal gland is a neuroendocrine transducer that forms an integral part of the brain. Through nocturnally elevated synthesis and release neurohormone melatonin, encodes disseminates information on circadian time, thus coupling outside world to biochemical physiological internal demands body. Approaches better understand molecular details behind rhythmic signalling in are limited but implicitly warranted, as chronobiological dysfunctions often associated with alterations melatonin synthesis. Current knowledge based minimally invasive analyses, by comparison events between different vertebrate species, emphasis put data acquired sheep other primates. Together investigations using autoptic tissue, remnant silhouette premortem dynamics within hormone's biosynthesis pathway can be constructed. detected scenario generation positions surprisingly isolated. In this brain structure, protein-protein interactions nucleo-cytoplasmic protein shuttling indicate furthermore novel twist cells structure. These findings have seen light impaired observed elderly and/or demented patients, individuals affected Alzheimer's disease, Smith–Magenis syndrome, autism spectrum disorder sleep phase disorders. Already, recent advances understanding significantly helped counteract through proper restoration nocturnal surge.
Язык: Английский
Процитировано
393