efficacy and safety of dapagliflozin in patients with ckd: Real world experience in 93 italian renal clinics

Clinical Kidney Journal, Год журнала: 2024, Номер 18(1)

Опубликована: Дек. 3, 2024

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are recommended for reducing the renal and cardiovascular risk in patients with chronic kidney disease (CKD) based on positive results reported by clinical trials. However, real-world data efficacy safety of these drugs CKD population followed nephrology setting lacking. We report effects dapagliflozin using collected during a learning program which 105 nephrologists added (10 mg/day) to consecutive referred their clinics. Efficacy endpoints were albuminuria change determinants an decline ≥30%. Adverse events also collected. A total 1724 (age 67.4 ± 13.2 years, 72.8% males, diabetes 59.9%, eGFR 43.5 17.4 ml/min/1.73 m2, severe 70.1%) received 4 1 months. Dapagliflozin significantly reduced body weight (-1.3 kg), (-0.27 ml/min/month), blood pressure (-3.6/-1.7 mmHg). Albuminuria declined 25.1% (95%CI 23.0-27.2) from 500 mg/day [IQR 225-1425] 320 100-900]. reduction was ≥30% 48.3% patients, 0-29% 37.6% while it increased 14.1% patients. At logistic regression analysis, older age, female sex, use mineralocorticoid receptor antagonist, higher eGFR, all significant predictors 46 side leading drug discontinuation 36 (2%), acute injury urinary tract infection being most frequent adverse events. provide evidence anti-proteinuric short-term presence good profile nephrology.

Язык: Английский

Relationship between health system quality and racial and ethnic equity in diabetes care

Health Affairs Scholar, Год журнала: 2024, Номер 2(7)

Опубликована: Июнь 3, 2024

Abstract Failing to consider disparities in quality measures, such as by race and ethnicity, may obscure inequities care, which could exist facilities with overall high-quality ratings. We examined the relationship between racial ethnic diabetes care health facility–level performance on a diabetes-related measure within national dataset of veterans using Veterans Health Administration (VA) ambulatory March 1, 2020 Feburary 28, 2021, were eligible for assessment. found existed top-performing VA medical centers (VAMCs) among American Indian or Alaska Native (AIAN) (predicted probability = 30%), Black 29%), Hispanic VA-users 30%) vs White 26%). While similar relative across VAMCs at all levels, exacerbated AIAN Hawaiian Other Pacific Islander bottom-performing VAMCs. Equity remains an issue even providing care. Integrating equity component measures can incentivize greater focus improvement.

Язык: Английский

Table of Contents

American Journal of Kidney Diseases, Год журнала: 2023, Номер 82(1), С. A11 - A13

Опубликована: Июнь 21, 2023

Язык: Английский