Chronic kidney disease in older adults: challenges and opportunities for the primary care provider

BMC Primary Care, Journal Year: 2024, Volume and Issue: 25(1)

Published: Nov. 1, 2024

Kidney disease and its comorbidities disproportionately affect older persons. modifying therapy is underutilized in adults, as guidelines lack consensus on approaching diagnosis treatment adults. This review aims to highlight the challenges presented by, opportunities for, identifying treating CKD

Language: Английский

efficacy and safety of dapagliflozin in patients with ckd: Real world experience in 93 italian renal clinics

Clinical Kidney Journal, Journal Year: 2024, Volume and Issue: 18(1)

Published: Dec. 3, 2024

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are recommended for reducing the renal and cardiovascular risk in patients with chronic kidney disease (CKD) based on positive results reported by clinical trials. However, real-world data efficacy safety of these drugs CKD population followed nephrology setting lacking. We report effects dapagliflozin using collected during a learning program which 105 nephrologists added (10 mg/day) to consecutive referred their clinics. Efficacy endpoints were albuminuria change determinants an decline ≥30%. Adverse events also collected. A total 1724 (age 67.4 ± 13.2 years, 72.8% males, diabetes 59.9%, eGFR 43.5 17.4 ml/min/1.73 m2, severe 70.1%) received 4 1 months. Dapagliflozin significantly reduced body weight (-1.3 kg), (-0.27 ml/min/month), blood pressure (-3.6/-1.7 mmHg). Albuminuria declined 25.1% (95%CI 23.0-27.2) from 500 mg/day [IQR 225-1425] 320 100-900]. reduction was ≥30% 48.3% patients, 0-29% 37.6% while it increased 14.1% patients. At logistic regression analysis, older age, female sex, use mineralocorticoid receptor antagonist, higher eGFR, all significant predictors 46 side leading drug discontinuation 36 (2%), acute injury urinary tract infection being most frequent adverse events. provide evidence anti-proteinuric short-term presence good profile nephrology.

Language: Английский

Table of Contents

American Journal of Kidney Diseases, Journal Year: 2023, Volume and Issue: 82(1), P. A11 - A13

Published: June 21, 2023

Language: Английский