Gut dysbiosis-related thrombosis in inflammatory bowel disease: Potential disease mechanisms and emerging therapeutic strategies DOI Creative Commons
Alfredo Papa, Paolo Santini, Sara Sofia De Lucia

и другие.

Thrombosis Research, Год журнала: 2023, Номер 232, С. 77 - 88

Опубликована: Ноя. 6, 2023

Patients with inflammatory bowel disease (IBD) have an increased risk of developing venous thromboembolic events, which a considerable impact on morbidity and mortality. Chronic inflammation plays crucial role in the pathogenesis thrombotic events patients IBD. However, many unresolved questions remain, particularly regarding mechanisms that determine persistent state independent activity. This review explored gut microbiota dysbiosis intestinal barrier dysfunction, are considered distinctive features IBD, determining pro-thrombotic tendencies. Gut-derived endotoxemia due to translocation bacterial lipopolysaccharides (LPS) from intestine bloodstream metabolite trimethylamine-N-oxide (TMAO) most important molecules involved dysbiosis-related thrombosis. The pathogenic prothrombotic pathways linked LPS TMAO been discussed. Finally, we present emerging therapeutic approaches can help reduce LPS-mediated TMAO, such as restoring eubiosis, normalizing function, counterbalancing effects TMAO.

Язык: Английский

The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health: A Narrative Review” DOI Open Access
Vincenzo Abrignani, Andrea Salvo, Antonino Tuttolomondo

и другие.

Опубликована: Март 7, 2024

Mediterranean Diet (MD), rich in minimally processed plant foods and monounsaturated fats, but low saturated meat dairy products, represents one of the most studied diets for cardiovascular health. It has been shown, from both observational randomized controlled trials, that MD reduces body weight, improves disease surrogates such as waist-to-hip ratio, lipids, inflammation markers, even prevents development fatal non-fatal disease, diabetes, obesity, other diseases. However, it is unclear whether offers benefits its individual components or a whole. Furthermore, limitations methodology studies meta-analyses have raised some concerns on potential benefits. also associated with characteristic changes intestinal microbiota, mediated through constituents. These include increased growth species producing short-chain fatty acids, Clostridium leptum Eubacterium rectale, Bifidobacteria, Bacteroides Faecalibacterium prausnitzii species, reduced Firmicutes Blautia species. Such are known to be favorably inflammation, oxidative status, overall metabolic This review will focus effects health action gut microbioma.

Язык: Английский

Процитировано

13
Integrating multi-omics to unravel host-microbiome interactions in inflammatory bowel disease DOI Creative Commons
Yiran Zhang,

John P. Thomas,

Tamás Korcsmáros

и другие.

Cell Reports Medicine, Год журнала: 2024, Номер 5(9), С. 101738 - 101738

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

11
The 2023 Impact of Inflammatory Bowel Disease in Canada: Epidemiology of IBD DOI Creative Commons
Stephanie Coward, Eric I. Benchimol, M Ellen Kuenzig

и другие.

Journal of the Canadian Association of Gastroenterology, Год журнала: 2023, Номер 6(Supplement_2), С. S9 - S15

Опубликована: Сен. 1, 2023

Abstract Inflammatory bowel disease (IBD), consisting of Crohn’s and ulcerative colitis, is recognized across the world, though Canada has among highest burdens IBD in world. The Canadian Gastro-Intestinal Epidemiology Consortium (CanGIEC) led a six-province study that demonstrated compounding prevalence from 400 per 100,000 2002 to 636 2014. 2023 estimated at 825 100,000, meaning over 320,000 people are living with IBD. Prevalence forecasted rise by 2.44% year such 1.1% population, 470,000 Canadians, will live 2035. overall incidence 30 person-years, indicating 11,000 Canadians be newly diagnosed 2023. Incidence 0.58% up 32.1 rising propelled pediatric-onset IBD, which 1.23% 15.6 18.0 In contrast, rates adults seniors relatively stable. Understanding determinates expanded through prospective cohort studies as Colitis Genetic, Environmental, Microbial (CCC-GEM) project. Consensus recommendations towards diet, lifestyle, behavioural environmental modifications have been proposed international organizations goal optimizing control ultimately preventing development Despite these efforts, healthcare systems need prepare for number

Язык: Английский

Процитировано

23
Should the Mediterranean diet be recommended for inflammatory bowel diseases patients? A narrative review DOI Creative Commons
Alicja Ewa Ratajczak, Stefano Festa, Annalisa Aratari

и другие.

Frontiers in Nutrition, Год журнала: 2023, Номер 9

Опубликована: Янв. 10, 2023

Inflammatory bowel diseases (IBD) are chronic, progressive and relapsing inflammatory disorders of unknown etiology that may cause disability over time. Data from epidemiologic studies indicate diet play a role in the risk developing course IBD. It is known group beneficial bacteria was reduced IBD Mediterranean (MD)-which defined as eating habits characterized by high consumption plant foods, mainly cereals, vegetables, fruit well olive oil, small portions dairy products, sweets, sugar meat products-affects gut microbiota, enriching bacteria, which support barrier function reduce inflammation. Although several different favorable effects MD on IBD, adherence to patients generally low, including Basin. Patients avoid many products elements because there gastrointestinal symptoms. should be encouraged have healthy well-balanced according individual tolerance products. A good option seems modified MD, changing hard-to-digest easy digest.

Язык: Английский

Процитировано

22
Dietary Intake and Systemic Inflammation: Can We Use Food as Medicine? DOI
Erica Graff, Shyam Vedantam,

Mary Parianos

и другие.

Current Nutrition Reports, Год журнала: 2023, Номер 12(2), С. 247 - 254

Опубликована: Янв. 20, 2023

Язык: Английский

Процитировано

22
Epidemiology of Pediatric Inflammatory Bowel Disease DOI
Rabia Khan, M Ellen Kuenzig, Eric I. Benchimol

и другие.

Gastroenterology Clinics of North America, Год журнала: 2023, Номер 52(3), С. 483 - 496

Опубликована: Авг. 3, 2023

Язык: Английский

Процитировано

20
The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health: A Narrative Review DOI Open Access
Vincenzo Abrignani, Andrea Salvo, Gaetano Pacinella

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4942 - 4942

Опубликована: Апрель 30, 2024

The Mediterranean diet (MD), rich in minimally processed plant foods and monounsaturated fats but low saturated fats, meat, dairy products, represents one of the most studied diets for cardiovascular health. It has been shown, from both observational randomized controlled trials, that MD reduces body weight, improves disease surrogates such as waist-to-hip ratios, lipids, inflammation markers, even prevents development fatal nonfatal disease, diabetes, obesity, other diseases. However, it is unclear whether offers benefits its individual components or a whole. Furthermore, limitations methodology studies meta-analyses have raised some concerns over potential benefits. also associated with characteristic changes intestinal microbiota, mediated through constituents. These include increased growth species producing short-chain fatty acids, Clostridium leptum Eubacterium rectale, Bifidobacteria, Bacteroides, Faecalibacterium prausnitzii species, reduced Firmicutes Blautia species. Such are known to be favorably inflammation, oxidative status, overall metabolic This review will focus on effects health action gut microbiota.

Язык: Английский

Процитировано

9
The Benefits of the Mediterranean Diet on Inflamm-Aging in Childhood Obesity DOI Open Access
Valeria Calcaterra, Elvira Verduci,

Chiara Milanta

и другие.

Nutrients, Год журнала: 2024, Номер 16(9), С. 1286 - 1286

Опубликована: Апрель 25, 2024

(1) Background: Numerous elements of the Mediterranean diet (MD) have antioxidant and anti-inflammatory qualities. (2) Methods: We present a narrative review potential benefits dietary pattern in mitigating aging-related inflammation (inflamm-aging) associated with childhood obesity. The mechanisms underlying chronic obesity are also discussed. A total 130 papers were included after screening abstracts full texts. (3) Results: complex interplay between obesity, inflammation, related comorbidities is documented. MD emerges as promising for inflammation. Studies suggest that may contribute to weight control, improved lipid profiles, insulin sensitivity, endothelial function, thereby reducing risk metabolic syndrome children adolescents (4) Conclusions: While evidence supporting effects pediatric still evolving, existing literature underscores its preventive therapeutic strategy. However, adherence remains low among adolescents, necessitating targeted interventions promote healthier habits. Future high-quality intervention studies necessary elucidate specific impact on diverse populations comorbidities.

Язык: Английский

Процитировано

8
Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms DOI Creative Commons
Matthew A. Ciorba, Liza Konnikova, Simon A. Hirota

и другие.

Inflammatory Bowel Diseases, Год журнала: 2024, Номер 30(Supplement_2), С. S5 - S18

Опубликована: Май 1, 2024

Abstract Preclinical human inflammatory bowel disease (IBD) mechanisms is one of 5 focus areas the Challenges in IBD Research 2024 document, which also includes environmental triggers, novel technologies, precision medicine, and pragmatic clinical research. Herein, we provide a comprehensive overview current gaps diseases research that relate to preclinical deliver actionable approaches address them with on how these can lead advancements interception, remission, restoration. The document result multidisciplinary input from scientists, clinicians, patients, funders represents valuable resource for patient-centric prioritization. This section identifies major whose investigation will elucidate pathways be targeted unmet medical needs IBD. were identified following areas: genetics, risk alleles, epigenetics; microbiome; cell states interactions; barrier function; complications (specifically fibrosis stricturing); extraintestinal manifestations. To gaps, share specific opportunities basic translational scientists identify priority actions.

Язык: Английский

Процитировано

8
Is the Mediterranean Diet in Inflammatory Bowel Diseases Ready for Prime Time? DOI Creative Commons
Lihi Godny, Iris Dotan

Journal of the Canadian Association of Gastroenterology, Год журнала: 2023, Номер 7(1), С. 97 - 103

Опубликована: Дек. 23, 2023

The rising incidence of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), specifically in the developing world, suggests an important environmental effect. Amongst influences, dietary factors, particularly adoption a westernized diet, have been noticed. In contrast, Mediterranean diet (MED), characterized by high intake fruits, vegetables, whole grains, legumes, nuts, olive oil, moderate consumption animal ultra processed foods, has shown potential positive effects IBD.

Язык: Английский

Процитировано

14