Gut dysbiosis-related thrombosis in inflammatory bowel disease: Potential disease mechanisms and emerging therapeutic strategies DOI Creative Commons
Alfredo Papa, Paolo Santini, Sara Sofia De Lucia

и другие.

Thrombosis Research, Год журнала: 2023, Номер 232, С. 77 - 88

Опубликована: Ноя. 6, 2023

Patients with inflammatory bowel disease (IBD) have an increased risk of developing venous thromboembolic events, which a considerable impact on morbidity and mortality. Chronic inflammation plays crucial role in the pathogenesis thrombotic events patients IBD. However, many unresolved questions remain, particularly regarding mechanisms that determine persistent state independent activity. This review explored gut microbiota dysbiosis intestinal barrier dysfunction, are considered distinctive features IBD, determining pro-thrombotic tendencies. Gut-derived endotoxemia due to translocation bacterial lipopolysaccharides (LPS) from intestine bloodstream metabolite trimethylamine-N-oxide (TMAO) most important molecules involved dysbiosis-related thrombosis. The pathogenic prothrombotic pathways linked LPS TMAO been discussed. Finally, we present emerging therapeutic approaches can help reduce LPS-mediated TMAO, such as restoring eubiosis, normalizing function, counterbalancing effects TMAO.

Язык: Английский

Elucidation of the beneficial role of co-fermented whole grain quinoa and black barley with Lactobacillus on rats fed a western-style diet via a multi-omics approach DOI
Zi-Han Lin,

Lingyue Zhong,

Hui-Bin Jiang

и другие.

Food Research International, Год журнала: 2024, Номер 187, С. 114345 - 114345

Опубликована: Апрель 19, 2024

Язык: Английский

Процитировано

6
Challenges in IBD Research 2024: Environmental Triggers DOI Creative Commons
Ashwin N. Ananthakrishnan, Konstantinos Gerasimidis,

Shuk-Mei Ho

и другие.

Inflammatory Bowel Diseases, Год журнала: 2024, Номер 30(Supplement_2), С. S19 - S29

Опубликована: Май 1, 2024

Abstract Environmental factors play an important role in inflammatory bowel diseases (IBD; Crohn’s disease, [CD], ulcerative colitis [UC]). As part of the & Colitis Challenges 2024 agenda, Triggers workgroup summarized progress made field environmental impact on IBD since last cycle this document. The identified 4 unmet gaps content area pertaining to broad categories: (1) Epidemiology; (2) Exposomics and measurement; (3) Biologic mechanisms; (4) Interventions Implementation. Within epidemiology, biggest were study understudied populations including racial ethnic minority groups witnessing rapid rise disease incidence globally. also a lack robust knowledge how may difference stages for different disease-related end points. Leveraging existing cohorts targeted new prospective studies felt be need field. limitations traditional questionnaire-based assessment exposure placed high priority identification measurable biomarkers that can quantify cross-sectional longitudinal exposure. This would, turn, allow identifying biologic mechanisms influence understand heterogeneity effect such influences. Finally, working group emphasized importance generating high-quality data effective modification individual societal level, scalable sustainable methods deliver changes.

Язык: Английский

Процитировано

6
Design and reporting of prebiotic and probiotic clinical trials in the context of diet and the gut microbiome DOI
Kevin Whelan, Margaret Alexander, Claire Gaïani

и другие.

Nature Microbiology, Год журнала: 2024, Номер 9(11), С. 2785 - 2794

Опубликована: Окт. 30, 2024

Язык: Английский

Процитировано

6
Nutrition and immunity: perspectives on key issues and next steps DOI Creative Commons

Carolyn Dunbar,

Harold M. Aukema, Philip C. Calder

и другие.

Applied Physiology Nutrition and Metabolism, Год журнала: 2023, Номер 48(7), С. 484 - 497

Опубликована: Март 8, 2023

In January 2022, a group of experts came together to discuss current perspectives and future directions in nutritional immunology as part symposium organized by the Canadian Nutrition Society. Objectives included (1) creating an understanding complex interplay between diet immune system from infants through older adults, (2) illustrating role micronutrients that are vital system, (3) learning about research comparing impact various dietary patterns novel approaches reduce inflammation, autoimmune conditions, allergies, infections, (4) discussing select recommendations aimed at improving disease-specific function. The aims this review summarize identify key areas require additional exploration better understand dynamic relationship nutrition

Язык: Английский

Процитировано

13
Gut dysbiosis-related thrombosis in inflammatory bowel disease: Potential disease mechanisms and emerging therapeutic strategies DOI Creative Commons
Alfredo Papa, Paolo Santini, Sara Sofia De Lucia

и другие.

Thrombosis Research, Год журнала: 2023, Номер 232, С. 77 - 88

Опубликована: Ноя. 6, 2023

Patients with inflammatory bowel disease (IBD) have an increased risk of developing venous thromboembolic events, which a considerable impact on morbidity and mortality. Chronic inflammation plays crucial role in the pathogenesis thrombotic events patients IBD. However, many unresolved questions remain, particularly regarding mechanisms that determine persistent state independent activity. This review explored gut microbiota dysbiosis intestinal barrier dysfunction, are considered distinctive features IBD, determining pro-thrombotic tendencies. Gut-derived endotoxemia due to translocation bacterial lipopolysaccharides (LPS) from intestine bloodstream metabolite trimethylamine-N-oxide (TMAO) most important molecules involved dysbiosis-related thrombosis. The pathogenic prothrombotic pathways linked LPS TMAO been discussed. Finally, we present emerging therapeutic approaches can help reduce LPS-mediated TMAO, such as restoring eubiosis, normalizing function, counterbalancing effects TMAO.

Язык: Английский

Процитировано

12