Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 30, 2024
To
investigate
the
application
value
of
neutrophil
to
lymphocyte
count
ratio
(NLR)
in
prognostic
analysis
intrahepatic
cholangiocarcinoma
(ICC)
after
radical
resection,
and
offer
guidance
for
individualized
perioperative
diagnosis
treatment
ICC.
Cancers,
Год журнала:
2024,
Номер
16(9), С. 1761 - 1761
Опубликована: Май 1, 2024
Biliary
tract
cancers
(BTCs),
including
intrahepatic,
perihilar,
and
distal
cholangiocarcinomas,
as
well
gallbladder
cancer,
are
a
diverse
group
of
that
exhibit
unique
molecular
characteristics
in
each
their
anatomic
pathological
subtypes.
The
classification
BTCs
compromises
distinct
growth
patterns,
mass
forming,
periductal
infiltrating,
intraductal
growing
types,
which
can
be
identified
through
gross
examination.
small-duct
large-duct
types
intrahepatic
cholangiocarcinoma
have
been
recently
introduced
into
the
WHO
classification.
presentation
typical
clinical
symptoms,
extensive
utilization
radiological,
endoscopic,
diagnostic
methods,
is
thoroughly
detailed
description.
To
overcome
limitations
traditional
tissue
acquisition
new
modalities
being
explored.
treatment
landscape
also
rapidly
evolving
owing
to
emergence
subgroups
with
alterations
corresponding
targeted
therapies.
Furthermore,
we
emphasize
crucial
aspects
diagnosing
BTC
practical
settings.
Cancers,
Год журнала:
2024,
Номер
16(18), С. 3232 - 3232
Опубликована: Сен. 23, 2024
Cholangiocarcinoma
(CCA)
is
a
rare
and
aggressive
malignancy
originating
from
the
bile
ducts,
with
poor
prognosis
limited
treatment
options.
Traditional
therapies,
such
as
surgery,
chemotherapy,
radiation,
have
shown
efficacy,
especially
in
advanced
cases.
Recent
advancements
immunotherapy,
particularly
T
cell-based
therapies
like
chimeric
antigen
receptor
(CAR
T)
cells,
tumor-infiltrating
lymphocytes
(TILs),
cell
(TCR)-based
opened
new
avenues
for
improving
outcomes
CCA.
This
review
provides
comprehensive
overview
of
current
state
CCA,
focusing
on
CAR
therapy.
It
highlights
key
challenges,
including
complex
tumor
microenvironment
immune
evasion
mechanisms,
progress
made
preclinical
clinical
trials.
The
also
discusses
ongoing
trials
targeting
specific
CCA
antigens,
MUC1,
EGFR,
CD133,
evolving
role
precision
immunotherapy
enhancing
outcomes.
Despite
significant
progress,
further
research
needed
to
optimize
these
solid
tumors
By
summarizing
most
recent
results
future
directions,
this
underscores
promising
potential
revolutionizing
treatment.
Cancers,
Год журнала:
2024,
Номер
16(20), С. 3542 - 3542
Опубликована: Окт. 20, 2024
Treatment
options
for
intrahepatic
cholangiocarcinoma
(iCCA),
a
highly
malignant
tumor
with
poor
prognosis,
are
limited.
Recent
developments
in
immunotherapy
and
immune
checkpoint
inhibitors
(ICIs)
have
offered
new
hope
treating
iCCA.
However,
several
issues
remain,
including
the
identification
of
reliable
biomarkers
response
to
ICIs
immune-based
combinations.
Tumor
microenvironment
(TIME)
these
hepatobiliary
tumors
has
been
evaluated
is
under
assessment
this
setting
order
boost
efficacy
convert
immunologically
"cold"
"hot"
tumors.
Herein,
review
TIME
ICCA
its
critical
function
immunotherapy.
Moreover,
paper
also
discusses
potential
avenues
future
research,
novel
targets
emerging
treatment
plans
aimed
increase
effectiveness
survival
rates
iCCA
patients.
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 8, 2025
Cholangiocarcinoma
is
the
second
most
common
primary
liver
cancer,
and
its
global
incidence
has
increased
in
recent
years.
Radical
surgical
resection
systemic
chemotherapy
have
traditionally
been
standard
treatment
options.
However,
complexity
of
cholangiocarcinoma
subtypes
often
presents
a
challenge
for
early
diagnosis.
Additionally,
high
recurrence
rates
following
radical
resistance
to
late-stage
limit
benefits
patients.
Immunotherapy
emerged
as
an
effective
strategy
treating
various
types
shown
efficacy
when
combined
with
cholangiocarcinoma.
Current
immunotherapies
targeting
predominantly
focused
on
T
lymphocytes
within
tumor
microenvironment,
new
yielded
unsatisfactory
results
clinical
trials.
Therefore,
it
essential
achieve
comprehensive
understanding
unique
microenvironment
pivotal
role
it.
In
this
review,
we
describe
heterogeneous
immune
landscape
intercellular
communication
summarize
specific
distribution
lymphocytes.
Finally,
review
potential
checkpoints
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
ABSTRACT
Liquid
chromatography
(LC)
tandem
mass
spectrometry
(MS/MS)
is
one
of
the
widely
used
proteomic
techniques
to
study
alterations
occurred
at
protein
expression
level
as
well
post-translation
modifications
(PTMs)
proteins
that
are
relevant
different
physiological
or
pathological
statuses.
The
spectrometric
analysis
peptides
fragmented
from
(bottom-up
proteomics)
has
emerged
major
approaches
for
proteomics.
In
this
approach,
first
cleaved
into
and
with
PTMs
further
enriched
followed
by
LC-MS/MS
analysis.
To
achieve
a
reproducible
quantitative
characterization,
well-established
protease
digestion
PTM
peptide
enrichment
protocol
critical.
study,
we
developed
an
automated
sample
preparation
(AUTO-SP)
analyzing
utilizing
Patient-Derived
Xenograft
(PDX)
breast
cancer
tumors
(basal-like
luminal
subtypes).
amount
was
quantified
were
digested
using
AUTO-SP
each
PDX
sample.
Based
on
data-independent
acquisition
(DIA)-MS
data,
observed
samples
same
subtypes
highly
correlated
(>0.98).
Additionally,
>14,000
ubiquitinated
identified
in
when
ubiquitin
enrichment,
while
unique
pathways
basal-like
subtypes.
demonstrated
its
efficacy
provide
reliable
procedure
MS-based
analyses.
Hepatology Communications,
Год журнала:
2025,
Номер
9(3)
Опубликована: Фев. 26, 2025
Background:
Intrahepatic
cholangiocarcinoma
(ICC)
is
a
poor
prognosis
of
malignant
cancer
with
high
lymph
node
metastasis
and
resistance
to
systemic
therapies.
Recent
studies
suggested
that
the
involvement
IL-8
could
promote
ICC
through
epithelial–mesenchymal
transition
while
ICC-ALDH1A1
subtype
clarified
by
multi-omics
study.
The
correlation
between
ALDH1A1
in
remains
elusive.
This
study
aims
further
explore
roles
regulatory
mechanisms
ICC.
Methods:
We
analyzed
expression
patients
cells.
CXCR2
inhibitor
(SB225002)
was
applied
inhibit
function
IL-8,
JSH-23
NF-κB
signaling
pathway.
examined
effects
inhibition
on
NF-κB,
expression,
cell
growth,
migration,
invasion,
stemness.
Moreover,
we
tumor
growth
were
validated
using
subcutaneous
tumors
nude
mice.
Results:
IL-8-derived
cells
progression.
serum
associated
metastasis.
upregulate
activating
pathway,
promoting
Upregulation
activate
secretion,
forming
positive
feedback
loop
invasiveness
stemness
Conclusions:
Biology,
Год журнала:
2025,
Номер
14(4), С. 351 - 351
Опубликована: Март 28, 2025
CCA
is
a
highly
desmoplastic
malignant
cancer
and
the
second
most
common
primary
liver
malignancy
after
hepatocellular
carcinoma
(HCC),
accounting
for
approximately
15%
of
all
tumors.
has
poor
prognosis,
with
an
average
five-year
survival
rate
9%,
which
lower
than
that
pancreatic
cancer.
Although
considerable
efforts
have
been
invested
into
genomics,
epigenetics,
risk
factors,
very
little
known
about
what
might
key
causes
high
level
CCA.
In
this
review,
we
analyze
incidence
mortality
in
different
regions
based
on
data
from
1994
to
2022
obtained
International
Agency
Research
Cancer
(IARC),
discuss
current
status
treatment
disease,
focus
be
main
factors
contributing
CCA:
alkalosis
caused
by
Fenton
reaction,
hypoxia,
TIME.
The
review
includes
studies
published
1979
2024,
aiming
provide
updated
synthesis
basic
early
classical
theoretical
knowledge
By
revealing
epidemiological
characteristics
CCA,
potential
mechanisms
malignancy,
challenges
treatment,
aims
new
directions
future
research,
promote
development
personalized
strategies,
facilitate
deeper
understanding
more
effective
management
worldwide.