Cascade C(sp3)-H Bond Functionalization/Cyclization Reaction for the Synthesis of 3,3-Disubstituted Oxindoles by Decatungstate Photocatalysis DOI

X.-N. Fang,

Jiaxing Lv,

Shuxin Yang

и другие.

Tetrahedron, Год журнала: 2025, Номер unknown, С. 134578 - 134578

Опубликована: Март 1, 2025

Язык: Английский

Redox-Neutral Radical Cascade Cyclization of N-Arylacrylamides with Unactivated Alkyl and Aryl Chlorides DOI

Avishek Kumar Jha,

Dhananjay P. Nair,

Munaifa Arif

и другие.

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(21), С. 15389 - 15394

Опубликована: Окт. 24, 2023

Herein, we report the first metal-free, redox-neutral strategy for radical cascade alkylative addition, cyclization of N-arylacrylamides with unactivated alkyl chlorides to give corresponding 3,3-disubstituted oxindoles in moderate good yields. This transformation's salient features are utilization an organo photocatalyst, mild reaction conditions, and broad substrate scope. Moreover, this methodology is suitable hetero cycle derived acrylamides further allowed utilize aryl reaction. Finally, DFT studies allow us shed light on mechanism.

Язык: Английский

Процитировано

11
Cascade C(sp3)-H Bond Functionalization/Cyclization Reaction for the Synthesis of 3,3-Disubstituted Oxindoles by Decatungstate Photocatalysis DOI

X.-N. Fang,

Jiaxing Lv,

Shuxin Yang

и другие.

Tetrahedron, Год журнала: 2025, Номер unknown, С. 134578 - 134578

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0