Cascade C(sp3)-H Bond Functionalization/Cyclization Reaction for the Synthesis of 3,3-Disubstituted Oxindoles by Decatungstate Photocatalysis DOI

X.-N. Fang,

Jiaxing Lv,

Shuxin Yang

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134578 - 134578

Published: March 1, 2025

Language: Английский

Redox-Neutral Radical Cascade Cyclization of N-Arylacrylamides with Unactivated Alkyl and Aryl Chlorides DOI

Avishek Kumar Jha,

Dhananjay P. Nair,

Munaifa Arif

et al.

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(21), P. 15389 - 15394

Published: Oct. 24, 2023

Herein, we report the first metal-free, redox-neutral strategy for radical cascade alkylative addition, cyclization of N-arylacrylamides with unactivated alkyl chlorides to give corresponding 3,3-disubstituted oxindoles in moderate good yields. This transformation's salient features are utilization an organo photocatalyst, mild reaction conditions, and broad substrate scope. Moreover, this methodology is suitable hetero cycle derived acrylamides further allowed utilize aryl reaction. Finally, DFT studies allow us shed light on mechanism.

Language: Английский

Citations

11
Cascade C(sp3)-H Bond Functionalization/Cyclization Reaction for the Synthesis of 3,3-Disubstituted Oxindoles by Decatungstate Photocatalysis DOI

X.-N. Fang,

Jiaxing Lv,

Shuxin Yang

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134578 - 134578

Published: March 1, 2025

Language: Английский

Citations

0