Extracellular Vesicles and Glaucoma: Opportunities and Challenges
Current Eye Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 10
Опубликована: Фев. 3, 2025
Purpose
Glaucoma
is
one
of
the
leading
causes
irreversible
blindness,
characterized
by
progressive
visual
field
loss.
Several
risk
factors
are
associated
with
developing
disease.
However,
exact
mechanisms
or
pathological
pathways
involved
still
unknown.
There
an
urgent
need
to
find
and
biomarkers
for
early
detection
therapy
halt
progression
cure
Extracellular
vesicles
(EVs),
specifically
exosomes,
have
emerged
as
a
crucial
player
in
all
aspects
glaucoma,
including
pathogenesis
therapeutic
application
their
cell-cell
communication
properties.
Язык: Английский
Efficacy of Ginkgo biloba on parameters in glaucoma: A systematic review
PLoS ONE,
Год журнала:
2025,
Номер
20(2), С. e0314644 - e0314644
Опубликована: Фев. 14, 2025
This
study
aims
to
analyse
the
efficacy
of
GBE
administration
in
patients
with
glaucoma
and
healthy
volunteers.
systematic
review
was
performed
according
PRISMA
2020
guidelines.
All
clinical
studies
investigating
on
intraocular
pressure
(IOP),
corrected
pattern
standard
deviation
(CPSD)
mean
visual
field
testing,
heart
rate
were
considered.
The
weighted
difference
(MD)
effect
measure,
95%
confidence
interval
(CI),
t-test
used
for
continuous
variables.
Data
from
8
studies,
including
428
patients,
retrieved.
age
all
51.1
±
15.5
years.
median
follow-up
3.7
(IQR
9.4)
months.
not
associated
an
improvement
IOP
(MD
-1.5;
95%CI
-7.1
9.6;
P
=
0.5),
0.7;
-9.4
8.2;
0.8),
CPSD
-1.6;
-3.8
6.9;
or
-2.5;
-11.5
16.5;
0.4)
baseline
last
follow-up.
There
no
between
versus
control
group
1.1;
-5.7
3.5;
0.4),
-0.4;
-9.1
9.9;
0.9),
0.3;
-6.8
6.2;
-1.3;
-15.1
17.7;
0.8)
at
Currently,
evidence
is
sufficient
conclude
that
affects
IOP,
deviation,
CPSD,
These
conclusions
must
be
interpreted
caution
given
limitations
reviewed
particularly
time
included
studies.
Язык: Английский
Twelve-Month Outcomes of Combined Phacoemulsification with Ab Interno Canaloplasty Versus Single-Use Dual Blade Goniotomy in Glaucoma Patients
Klinische Monatsblätter für Augenheilkunde,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
To
compare
the
efficacy
and
safety
of
combined
phacoemulsification
with
ab
interno
canaloplasty
(Phaco-AbiC)
versus
single-use
dual
blade
goniotomy
(Phaco-DBG).
In
this
prospective
consecutive
case
series,
intraocular
pressure
(IOP),
number
IOP-lowering
medications,
mean
deviation
(MD)
visual
field
testing,
surgery-related
complications
were
evaluated
in
25
eyes
following
Phaco-AbiC
20
Phaco-DBG
through
12
months
follow-up.
Qualified
or
complete
success
was
defined
as
postoperative
IOP
lower
than
21,
18,
16
mmHg
without
medications.
At
12-month
follow-up,
significantly
reduced
compared
to
baseline
(14.2
±
2.7
19.2
4.7
mmHg,
p
<
0.001)
groups
(16.7
3.4
19.9
3.9
0.001).
higher
(p
=
0.011).
Compared
baseline,
medications
(1.2
1.4
2.4
1.0,
(0.8
0.9
2.1
0.9,
at
For
qualified
rate
(36.0
76.2%,
respectively)
(17.5
40.6%;
0.037;
0.007,
respectively).
No
severe
intra-
occurred.
Both
achieved
a
significant
reduction
Phaco-DBG.
Язык: Английский
Factors influencing the outcomes of trabeculectomy, conventional canaloplasty, and mitomycin C augmented canaloplasty
Graefe s Archive for Clinical and Experimental Ophthalmology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 26, 2024
Язык: Английский
Monitoring of several morphometric parameters of the optic nerve and retina in persons without glaucoma and patients with primary open-angle glaucoma using various types of spectacle correction
Journal of Volgograd State Medical University,
Год журнала:
2024,
Номер
21(3), С. 48 - 54
Опубликована: Окт. 27, 2024
Purpose:
to
perform
long-term
monitoring
of
the
state
several
morphometric
parameters
retina
and
optic
nerve
in
persons
without
glaucoma
patients
with
primary
open-angle
(POAG)
conditions
achieving
tolerant
target
IOP
against
background
use
various
types
spectacle
correction.
Material
methods:
139
aged
40–60
years
clinical
refraction
were
examined,
41
subjects
(81
eyes)
them
glaucoma,
98
(164
had
POAG
at
stage
I–II.
In
addition
standard
methods,
scope
examination
included
optical
coherence
tomography
(OCT)
central
area
determine
thickness
retinal
fiber
layer
(RNFL),
ganglion
cell
complex
(RGCC)
neuroretinal
rim
(NRR).
The
study
was
conducted
4
observation
groups.
first
(21subjects)
second
(20
subjects)
groups
represented
by
who
used
monofocal
correction
progressive
for
near
work,
respectively.
third
(50
fourth
(48
composed
also
used,
respectively,
vision
or
topical
hypotensive
therapy
achievement
IOP.
follow-up
period
three
years.
Results:
There
no
significant
changes
NRR
(p
0,5)
RNFL
0,2)
RGCC
0,3)
over
three-year
all
glaucoma.
applied
correction,
negative
dynamics
revealed
during
period.
using
noticeable
losses
0,05)
a
decrease
0,3).
Conclusion:
provides
accommodative
regulation
implements
an
indirect
neuroprotective
effect.
Язык: Английский