Monitoring of several morphometric parameters of the optic nerve and retina in persons without glaucoma and patients with primary open-angle glaucoma using various types of spectacle correction DOI Open Access

I.A. Gndoyan,

N. A. Kuznetsova,

L.B. Kushtareva

et al.

Journal of Volgograd State Medical University, Journal Year: 2024, Volume and Issue: 21(3), P. 48 - 54

Published: Oct. 27, 2024

Purpose: to perform long-term monitoring of the state several morphometric parameters retina and optic nerve in persons without glaucoma patients with primary open-angle (POAG) conditions achieving tolerant target IOP against background use various types spectacle correction. Material methods: 139 aged 40–60 years clinical refraction were examined, 41 subjects (81 eyes) them glaucoma, 98 (164 had POAG at stage I–II. In addition standard methods, scope examination included optical coherence tomography (OCT) central area determine thickness retinal fiber layer (RNFL), ganglion cell complex (RGCC) neuroretinal rim (NRR). The study was conducted 4 observation groups. first (21subjects) second (20 subjects) groups represented by who used monofocal correction progressive for near work, respectively. third (50 fourth (48 composed also used, respectively, vision or topical hypotensive therapy achievement IOP. follow-up period three years. Results: There no significant changes NRR (p 0,5) RNFL 0,2) RGCC 0,3) over three-year all glaucoma. applied correction, negative dynamics revealed during period. using noticeable losses 0,05) a decrease 0,3). Conclusion: provides accommodative regulation implements an indirect neuroprotective effect.

Language: Английский

Efficacy of Ginkgo biloba on parameters in glaucoma: A systematic review DOI Creative Commons
J. C. Prinz, Verena Prokosch‐Willing, Xiaosha Wang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0314644 - e0314644

Published: Feb. 14, 2025

This study aims to analyse the efficacy of GBE administration in patients with glaucoma and healthy volunteers. systematic review was performed according PRISMA 2020 guidelines. All clinical studies investigating on intraocular pressure (IOP), corrected pattern standard deviation (CPSD) mean visual field testing, heart rate were considered. The weighted difference (MD) effect measure, 95% confidence interval (CI), t-test used for continuous variables. Data from 8 studies, including 428 patients, retrieved. age all 51.1 ± 15.5 years. median follow-up 3.7 (IQR 9.4) months. not associated an improvement IOP (MD -1.5; 95%CI -7.1 9.6; P = 0.5), 0.7; -9.4 8.2; 0.8), CPSD -1.6; -3.8 6.9; or -2.5; -11.5 16.5; 0.4) baseline last follow-up. There no between versus control group 1.1; -5.7 3.5; 0.4), -0.4; -9.1 9.9; 0.9), 0.3; -6.8 6.2; -1.3; -15.1 17.7; 0.8) at Currently, evidence is sufficient conclude that affects IOP, deviation, CPSD, These conclusions must be interpreted caution given limitations reviewed particularly time included studies.

Language: Английский

Citations

0
Twelve-Month Outcomes of Combined Phacoemulsification with Ab Interno Canaloplasty Versus Single-Use Dual Blade Goniotomy in Glaucoma Patients DOI
J. C. Prinz, Niklas Plange, Hannah Schellhase

et al.

Klinische Monatsblätter für Augenheilkunde, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

To compare the efficacy and safety of combined phacoemulsification with ab interno canaloplasty (Phaco-AbiC) versus single-use dual blade goniotomy (Phaco-DBG). In this prospective consecutive case series, intraocular pressure (IOP), number IOP-lowering medications, mean deviation (MD) visual field testing, surgery-related complications were evaluated in 25 eyes following Phaco-AbiC 20 Phaco-DBG through 12 months follow-up. Qualified or complete success was defined as postoperative IOP lower than 21, 18, 16 mmHg without medications. At 12-month follow-up, significantly reduced compared to baseline (14.2 ± 2.7 19.2 4.7 mmHg, p < 0.001) groups (16.7 3.4 19.9 3.9 0.001). higher (p = 0.011). Compared baseline, medications (1.2 1.4 2.4 1.0, (0.8 0.9 2.1 0.9, at For qualified rate (36.0 76.2%, respectively) (17.5 40.6%; 0.037; 0.007, respectively). No severe intra- occurred. Both achieved a significant reduction Phaco-DBG.

Language: Английский

Citations

0
Extracellular Vesicles and Glaucoma: Opportunities and Challenges DOI
Mofazzal Hossain, Yutao Liu

Current Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: Feb. 3, 2025

Purpose Glaucoma is one of the leading causes irreversible blindness, characterized by progressive visual field loss. Several risk factors are associated with developing disease. However, exact mechanisms or pathological pathways involved still unknown. There an urgent need to find and biomarkers for early detection therapy halt progression cure Extracellular vesicles (EVs), specifically exosomes, have emerged as a crucial player in all aspects glaucoma, including pathogenesis therapeutic application their cell-cell communication properties.

Language: Английский

Citations

0
Factors influencing the outcomes of trabeculectomy, conventional canaloplasty, and mitomycin C augmented canaloplasty DOI Creative Commons
J. C. Prinz, Matthias Fuest, David Kuerten

et al.

Graefe s Archive for Clinical and Experimental Ophthalmology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

Language: Английский

Citations

1
Monitoring of several morphometric parameters of the optic nerve and retina in persons without glaucoma and patients with primary open-angle glaucoma using various types of spectacle correction DOI Open Access

I.A. Gndoyan,

N. A. Kuznetsova,

L.B. Kushtareva

et al.

Journal of Volgograd State Medical University, Journal Year: 2024, Volume and Issue: 21(3), P. 48 - 54

Published: Oct. 27, 2024

Purpose: to perform long-term monitoring of the state several morphometric parameters retina and optic nerve in persons without glaucoma patients with primary open-angle (POAG) conditions achieving tolerant target IOP against background use various types spectacle correction. Material methods: 139 aged 40–60 years clinical refraction were examined, 41 subjects (81 eyes) them glaucoma, 98 (164 had POAG at stage I–II. In addition standard methods, scope examination included optical coherence tomography (OCT) central area determine thickness retinal fiber layer (RNFL), ganglion cell complex (RGCC) neuroretinal rim (NRR). The study was conducted 4 observation groups. first (21subjects) second (20 subjects) groups represented by who used monofocal correction progressive for near work, respectively. third (50 fourth (48 composed also used, respectively, vision or topical hypotensive therapy achievement IOP. follow-up period three years. Results: There no significant changes NRR (p 0,5) RNFL 0,2) RGCC 0,3) over three-year all glaucoma. applied correction, negative dynamics revealed during period. using noticeable losses 0,05) a decrease 0,3). Conclusion: provides accommodative regulation implements an indirect neuroprotective effect.

Language: Английский

Citations

0