Approach Toward Stereoselective α‐Arylation by Pd/Cu‐Catalyzed Arylboration of Electron Deficient Alkenes
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Abstract
Palladium‐catalyzed
cross
coupling
of
enolates—α‐arylation—is
an
established
method
for
chemical
synthesis.
A
major
challenge
in
the
field
is
control
stereochemistry
α‐carbon.
This
typically
due
to
facile
epimerization
under
basic
reaction
conditions
α‐arylation.
In
this
study,
alternative
approach
presented
that
involves
Pd/Cu‐catalyzed
arylboration
electron
deficient
alkenes.
The
products
are
generated
with
high
levels
diastereoselectivity
a
broad
range
substitution
patterns.
Enantioselective
variants
also
addition
product
derivatizations.
Язык: Английский
Approach Toward Stereoselective α‐Arylation by Pd/Cu‐Catalyzed Arylboration of Electron Deficient Alkenes
Angewandte Chemie,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Abstract
Palladium‐catalyzed
cross
coupling
of
enolates—α‐arylation—is
an
established
method
for
chemical
synthesis.
A
major
challenge
in
the
field
is
control
stereochemistry
α‐carbon.
This
typically
due
to
facile
epimerization
under
basic
reaction
conditions
α‐arylation.
In
this
study,
alternative
approach
presented
that
involves
Pd/Cu‐catalyzed
arylboration
electron
deficient
alkenes.
The
products
are
generated
with
high
levels
diastereoselectivity
a
broad
range
substitution
patterns.
Enantioselective
variants
also
addition
product
derivatizations.
Язык: Английский