Approach Toward Stereoselective α‐Arylation by Pd/Cu‐Catalyzed Arylboration of Electron Deficient Alkenes

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Palladium‐catalyzed cross coupling of enolates—α‐arylation—is an established method for chemical synthesis. A major challenge in the field is control stereochemistry α‐carbon. This typically due to facile epimerization under basic reaction conditions α‐arylation. In this study, alternative approach presented that involves Pd/Cu‐catalyzed arylboration electron deficient alkenes. The products are generated with high levels diastereoselectivity a broad range substitution patterns. Enantioselective variants also addition product derivatizations.

Language: Английский

Approach Toward Stereoselective α‐Arylation by Pd/Cu‐Catalyzed Arylboration of Electron Deficient Alkenes

Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Palladium‐catalyzed cross coupling of enolates—α‐arylation—is an established method for chemical synthesis. A major challenge in the field is control stereochemistry α‐carbon. This typically due to facile epimerization under basic reaction conditions α‐arylation. In this study, alternative approach presented that involves Pd/Cu‐catalyzed arylboration electron deficient alkenes. The products are generated with high levels diastereoselectivity a broad range substitution patterns. Enantioselective variants also addition product derivatizations.

Language: Английский