Sulfilimines: An Underexplored Bioisostere for Drug Design?
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Sulfilimines
have
so
far
received
little
attention
as
a
bioisostere
for
sulfoxides
in
the
design
of
biologically
active
compounds.
A
recent
study
on
physicochemical
and
vitro
drug-like
properties
shows
that
sulfilimines
deserve
place
medicinal
chemist's
toolbox.
Язык: Английский
Anionic Stereogenic-at-Cobalt(III) Complex-Enabled Asymmetric Oxidation of N,N-Dialkyl Sulfenamides
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
An
asymmetric
oxidation
of
N,N-dialkyl
sulfenamides
is
exhibited
by
using
anionic
stereogenic-at-cobalt(III)
complexes
as
catalysts.
This
protocol
provides
an
alternative
approach
to
access
a
diverse
set
chiral
tertiary
sulfinamides
with
high
enantioselectivities
(24
examples,
up
94:6
e.r.).
Additionally,
control
experiments
suggest
that
this
could
be
accomplished
through
cationic
S(IV)
intermediate.
Язык: Английский
Strategic Synthesis of Sulfinamides as Versatile S(IV) Intermediates
ACS Organic & Inorganic Au,
Год журнала:
2024,
Номер
5(1), С. 1 - 12
Опубликована: Ноя. 30, 2024
Sulfinamides
constitute
adaptable
S(IV)
intermediates
with
a
sulfur
stereocenter,
having
emerging
interest
in
divergent
synthesis
of
high-valent
S(VI)
functional
bioisosteres.
Recent
years
have
witnessed
the
strategic
development
mild
and
selective
synthetic
routes
for
highly
functionalized
sulfinamides,
employing
stable
organometallic
reagents,
carbon-centered
radical
precursors,
other
abundant
coupling
partners
merged
various
reagents
arena
metal,
photoredox,
organocatalysis.
Furthermore,
asymmetric
metal
organocatalysis
enabled
stereoselective
enantioenriched
sulfinamides.
In
this
Perspective,
we
present
recent
(2021
to
present)
advancement
methods
toward
Язык: Английский
Synthesis of Sulfenamides via Photoredox N–S Coupling of Dialkyl Azodicarboxylates and Thiols
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
We
herein
report
a
photoredox
N–S
coupling
reaction
between
dialkyl
azodicarboxylates
and
thiols
to
access
sulfenamide
scaffolds.
This
proceeds
under
mild,
green,
operationally
simple
conditions,
offering
broad
scope
of
sulfenamides
with
high
yields
excellent
atom
efficiency.
Mechanistic
investigations
revealed
this
followed
photoinitiated
radical
pathway
in
which
iodide
plays
crucial
role
as
both
initiator
single-electron
reductant.
Язык: Английский