Multiple dimensions of neurological injury in a liver transplant recipient with cryptococcal meningitis DOI Creative Commons
Shmuel Shoham, Sabin Thapaliya, Robin K. Avery

и другие.

Deleted Journal, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

ABSTRACT Background Meningitis due to Cryptococcus neoformans continues cause substantial morbidity and mortality in victims of this infection. Worldwide, immunosuppression uncontrolled HIV disease is the main risk factor. In United States, however, a percentage cryptococcal meningitis cases occur people with non-HIV immune compromising conditions such as solid organ transplantation. Neurological damage can be caused by direct fungal-induced injury, consequence elevated intracranial pressure, immune-mediated injury. An understanding these pathophysiological processes an appreciation for roles specific treatments address them are necessary optimal care patients meningitis. Case Summary report, we present case liver transplant recipient whose manifestations were (i) fungal invasion, (ii) (iii) over-exuberant response that blossomed soon after reduction clearance cerebrospinal fluid culture. Conclusion This patient’s course exemplifies multidimensional nature neurological injury diverse treatment strategies required infection complications. IMPORTANCE critical management highlights three so they quickly diagnosed treated before irreversible occurs.

Язык: Английский

Waldenström's Macroglobulinemia/Lymphoplasmacytic Lymphoma Developing Renal AA Amyloidosis: A Case Report and Literature Review DOI Open Access

Yusuke Ishizuka,

Yuji Oe,

S. Kinomura

и другие.

Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

AA amyloidosis is a rare renal complication of Waldenström's macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL). A 66-year-old man with WM/LPL presented nephrotic syndrome. biopsy showed amyloidosis. Chemotherapy resulted in the remission hematologic and syndromes. Two years into follow-up, he became infected COVID-19 had massive proteinuria, despite no relapse WM/LPL. second confirmed diagnosis However, increased prednisolone did not improve proteinuria. The patient ultimately died cryptococcal meningitis. This case highlights diverse spectrum involvement monoclonal IgM-secreting diseases difficulty managing fatal complications.

Язык: Английский

Процитировано

1
The microbial damage and host response framework: lesson learned from pathogenic survival trajectories and immunoinflammatory responses of Talaromyces marneffei infection DOI Creative Commons
Kritsada Pruksaphon, Artid Amsri, Juthatip Jeenkeawpieam

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 12, 2024

The adverse outcomes of fungal infection in mammalian hosts depend on the complex interactions between host immune system and pathogen virulence-associated traits. main clinical problems arise when response is either too weak to effectively eliminate or overly aggressive, resulting tissue damage rather than protection. This article will highlight current knowledge regarding virulence attributions mechanisms involved dual-sided role immunopathogenesis thermally dimorphic fungus Talaromyces marneffei through lens framework (DRF) microbial pathogenesis model.

Язык: Английский

Процитировано

6
Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome DOI Creative Commons
Jessica C. Hargarten, Kenneth Ssebambulidde, Seher Anjum

и другие.

Science Advances, Год журнала: 2025, Номер 11(12)

Опубликована: Март 21, 2025

Therapies to reduce neuroinflammation following resolution of acute central nervous system (CNS) infections are urgently needed, particularly for patients with non–HIV-associated cryptococcal meningoencephalitis complicated by a postinfectious inflammatory response syndrome (cPIIRS). To identify druggable targets in cPIIRS, patient cerebral spinal fluid samples underwent transcriptional analysis, revealing Janus kinase/signal transducer and activator transcription (JAK/STAT) pathway dominance neuroinflammatory gene signatures. MurinecPIIRS models recapitulated this predominance treatment the JAK inhibitor ruxolitinib, confirmed mechanistic requirement disease pathology. Ruxolitinib improved markers neuronal damage, reduced activated T cell myeloid cells, weight. On basis these findings, we conducted first-in-human ruxolitinib cPIIRS (NCT00001352). six led demonstrated tolerability, reductions biomarkers immune brain imaging. These results advocate pathway-instructed therapeutics diseases endorse inhibitors further clinical studies cPIIRS.

Язык: Английский

Процитировано

0
Construction of a nomogram model based on multiple factors to differentiate cryptococcal meningitis from tuberculous meningitis in HIV-Infected patients DOI Creative Commons
Hao Xiao, Cheng Chen,

Fangbo Lin

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 11, 2025

Язык: Английский

Процитировано

0
Persistent NK cell deficiency associated with pulmonary cryptococcosis DOI Creative Commons

M. Martinot,

Shu Shun Li, Catherine Farnarier

и другие.

Annals of Clinical Microbiology and Antimicrobials, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 18, 2025

We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed primary NK cell deficiency associated with secondary impaired anti-Cryptococcus CD8 lymphocyte response and the expansion of CD8Vβ14 + T clone. This case illustrates potential role cells immunity against Cryptococcus.

Язык: Английский

Процитировано

0
A fatal case of chronic Cryptococcus neoformans meningitis progressing over a 4-year period following cladribine therapy DOI Creative Commons
Christina Ekenberg, Jon Gitz Holler, Christian Stenör

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

ABSTRACT Background Globally, cryptococcal meningitis (CM) remains most common in human immunodeficiency virus (HIV)-infected individuals. However, Cryptococcus neoformans increasingly causes CM patients with non-HIV immunosuppression due to glucocorticoid treatment, organ transplantation, and hematological cancer, among others. The clinical presentations of disease are highly host dependent, resulting varying immunocompromised patients. Case Summary Here, we report a fatal case patient previously treated cladribine hairy cell leukemia. had an atypical presentation, the progressed slowly over 4-year period, hampering timely diagnostics treatment. Retrospective analyses cerebrospinal fluid blood revealed that antigen (CrAg) test was already positive when initially presented pleocytosis 3 years prior diagnosis. Conclusion This adds valuable knowledge our current understanding unusual time course furthermore demonstrates important pitfalls associated cryptococcosis HIV-negative patients, including presentation diagnostic challenges which resulted delay years. Morbidity mortality remain high, growing population increased awareness low threshold screen these for CrAg warranted.

Язык: Английский

Процитировано

0
Epidemiological Study of Cryptococcus gattii Complex Infection in Domestic and Wild Animals in Oregon DOI Creative Commons

Stephen A. Ballard,

Alexandria S. Montgomery,

I.C. Rose

и другие.

Veterinary Sciences, Год журнала: 2025, Номер 12(2), С. 185 - 185

Опубликована: Фев. 19, 2025

The members of the Cryptococcus gattii species complex are etiologic agents potentially fatal human infection. C. causes disease in both immunocompetent and immunocompromised hosts. In early 2000s, infection caused by emerged Pacific Northwest US. While many studies have been published about infection, epidemiological characteristics animals, with a possible role not investigated. Cases diagnosed animals Oregon from 2008 to 2019 were cataloged county, animal, site season year, genotype. One hundred nine cases diagnosed, among genotypes gattii, VGII (Cryptococcus deuterogatti) VGIIa, VGIIb, VGIIc was responsible for 98% cases. VGIIa identified more than 50% bacilliporus (VGIII) only isolated cat patients. majority infections dogs cats, although caprines, equines, camelids, ovines, elk also seen disease. most common brain; that cats nasal cavity skin, while lung affected camelids elk. Marion Lane Counties account infections, followed Clackamas, Benton, Multnomah Counties. predominantly during Fall Winter months, except Benton County, where it commonly Summer months. This study reviews all Department Public Health veterinarians years between 2019.

Язык: Английский

Процитировано

0
An Atypical Presentation of Immune Reconstitution Inflammatory Syndrome (Iris) in a Patient with Cryptococcal Meningitis in the Setting of Fingolimod Therapy for Multiple Sclerosis DOI
Henco Nel, Siong Hui

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
The Diagnostic Role of Elevated Serum Cryptococcal Antigen Titers in Patients with Suspected Cryptococcal Meningitis When Lumbar Puncture Is Contraindicated: A case Report DOI Creative Commons

Asmus Tukundane,

Richard Kwizera, Lillian Tugume

и другие.

Medical Mycology Case Reports, Год журнала: 2025, Номер unknown, С. 100700 - 100700

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Polymorphic α-Glucans as Structural Scaffolds inCryptococcusCell Walls for Chitin, Capsule, and Melanin: Insights from13C and1H Solid-State NMR DOI

Ankur Ankur,

Jayasubba Reddy Yarava, Isha Gautam

и другие.

Опубликована: Апрель 18, 2025

ABSTRACT Cryptococcus species are major fungal pathogens responsible for life-threatening infections in approximately a million individuals globally each year, with alarmingly high mortality rates. These fungi distinguished by distinctive cell wall architecture further reinforced two virulence-associated layers, melanin and capsule, rendering them insensitive to antifungal agents targeting the wall, such as echinocandins. The molecular interplay between these three biomolecular layers remains poorly understood. Here we employ solid-state NMR spectroscopy examine intact cells of both wild-type capsule-deficient strains C. neoformans , along its melanized cells. High-resolution 13 C 1 H data revealed five distinct structural forms α-1,3-glucans that play versatile roles forming rigid scaffold interacting chitin microfibrils chitosan, stabilizing mobile matrix associating β-1,6-glucan small fraction β-1,3-glucan. Two primary were distributed throughout hosting deposition inner domain capsule attachment on surface. findings offer paradigm shift understanding cryptococcal interaction key virulence factors opposite sides, raising critical biochemical questions could inform development more effective treatments cryptococcosis.

Язык: Английский

Процитировано

0