Lab on a Chip, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 4, 2024
We fabricate 3D microfluidics and high-aspect-ratio walls (∼50 : 1) using a custom 5-axis CNC mill with sub-μm repeatability step resolution.
Язык: Английский
Biotechnology Advances, Год журнала: 2024, Номер 71, С. 108317 - 108317
Опубликована: Янв. 13, 2024
Язык: Английский
Процитировано
31
Drug Discovery Today, Год журнала: 2024, Номер 29(4), С. 103936 - 103936
Опубликована: Фев. 29, 2024
This review highlights the transformative impact of microfluidic technology on personalized drug delivery. Microfluidics addresses issues in traditional synthesis, providing precise control and scalability nanoparticle fabrication, platforms show high potential for versatility, offering patient-specific dosing real-time monitoring capabilities, all integrated into wearable technology. Covalent conjugation antibodies to nanoparticles improves bioactivity, driving innovations targeting. The integration microfluidics with sensor technologies artificial intelligence facilitates feedback autonomous adaptation delivery systems. Key challenges, such as droplet polydispersity fluidic handling, along future directions focusing reliability, are essential considerations advancing
Язык: Английский
Процитировано
24
Frontiers in Lab on a Chip Technologies, Год журнала: 2025, Номер 4
Опубликована: Янв. 28, 2025
Microfluidic systems, especially those using capillary forces, have recently attracted considerable interest due to their potential facilitate passive fluid management in portable diagnostic devices and point-of-care settings. These systems utilize forces autonomously regulate flow, eliminating the requirement for external power providing a more straightforward economical option compared active microfluidic systems. This review examines fundamental concepts of capillary-driven microfluidics, emphasizing significant progress design pumps valves, as well influence surface tension, wettability, geometrical configurations microchannels on enhancement dynamics. Furthermore, explores other configurations, such porous solid substrates, illustrate healthcare biochemical applications. Moreover, challenges related managing flow rates enhancing reproducibility are addressed, alongside recent innovations designed overcome these challenges. Capillary offer an effective reliable foundation developing miniaturized instruments, which hold across various domains, including biological research environmental monitoring.
Язык: Английский
Процитировано
2
Biosensors, Год журнала: 2025, Номер 15(4), С. 222 - 222
Опубликована: Март 31, 2025
The growing demand for real-time, non-invasive, and cost-effective health monitoring has driven significant advancements in portable point-of-care testing (POCT) devices. Among these, optical biosensors have emerged as promising tools the detection of critical biomarkers such uric acid (UA) blood glucose. Different transduction methods, like fluorescence, surface plasmon resonance (SPR), colorimetric approaches, are talked about, with a focus on how sensitive, specific, they are. Despite considerable advancements, several challenges persist, including sensor stability, miniaturization, interference effects, need calibration-free operation. This review also explores issues related to cost-effectiveness, data integration, wireless connectivity remote monitoring. further examines regulatory considerations commercialization aspects biosensors, addressing gap between research developments clinical implementation. Future perspectives emphasize integration artificial intelligence (AI) healthcare improved diagnostics, alongside development wearable implantable continuous Innovative potential change way people manage their by quickly accurately measuring glucose levels. is especially true decentralized solutions grows. By critically evaluating existing work exploring limitations opportunities field, this will help guide more efficient, accessible, reliable POCT devices that can improve patient outcomes quality life.
Язык: Английский
Процитировано
1
Micromachines, Год журнала: 2024, Номер 15(9), С. 1137 - 1137
Опубликована: Сен. 6, 2024
This review explores significant advancements in polymer science and fabrication processes that have enhanced the performance broadened application scope of microfluidic devices. Microfluidics, essential biotechnology, medicine, chemical engineering, relies on precise fluid manipulation micrometer-sized channels. Recent innovations materials, such as flexible, biocompatible, structurally robust polymers, been pivotal developing advanced systems. Techniques like replica molding, microcontact printing, solvent-assisted injection 3D printing are examined, highlighting their advantages recent developments. Additionally, discusses diverse applications polymer-based devices biomedical diagnostics, drug delivery, organ-on-chip models, environmental monitoring, industrial processes. paper also addresses future challenges, including enhancing resistance, achieving multifunctionality, ensuring biocompatibility, scaling up production. By overcoming these potential for widespread adoption impactful use technologies can be realized.
Язык: Английский
Процитировано
6
Micromachines, Год журнала: 2024, Номер 15(9), С. 1135 - 1135
Опубликована: Сен. 6, 2024
Inertial focusing-based Lab-on-Chip systems represent a promising technology for cell sorting in various applications, thanks to their alignment with the ASSURED criteria recommended by World Health Organization: Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, Delivered. focusing techniques using spiral microchannels offer rapid, portable, easy-to-prototype solution sorting. Various microfluidic devices have been investigated literature understand how hydrodynamic forces influence particle microchannels. This is crucial effective prototyping of that allow high-throughput efficient filtration particles different sizes. However, clear, comprehensive, organized overview current research this area lacking. review aims fill gap offering thorough summary existing literature, thereby guiding future experimentation facilitating selection geometries materials To end, we begin detailed theoretical introduction physical mechanisms underlying separation channels. We also dedicate section most commonly used microchannels, highlighting discussing respective advantages disadvantages. Subsequently, provide critical examination key details inertial across cross-sections (rectangular, trapezoidal, triangular, hybrid) as reported literature.
Язык: Английский
Процитировано
3
Applied Thermal Engineering, Год журнала: 2025, Номер unknown, С. 125536 - 125536
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(1)
Опубликована: Янв. 1, 2025
ABSTRACT Silicone rubbers, such as polydimethylsiloxane (PDMS), have been widely used in biotechnology and medical science because of their excellent properties. However, microfabrication silicone rubbers remains to be problematic the high viscosity adhesiveness (tackiness) rubber, making it difficult fill molds reproduce shapes during soft lithography. Also, patterns made rubber are prone pattern collapse. To address these, we designed molecules that can modified by radiation whose hardness adjusted after microfabrication. By combining materials with different chemical structures molecular weights, developed a low suitable for modification. The synthesized had filling ability micropatterned adhesiveness, which prevented Moreover, elastic modulus controlled using high‐energy electron beam (EB) irradiation. radiation‐modified sheet retained its transparency visible light, oxygen permeability, drug adsorption adhesion. utilizing these characteristics, new technique was produces microfabricated hydrophilicity imprinting technology followed EB Soft lithography then performed on transfer micropillar structure. Pillar were accurately fabricated diameter 1.0 μm or less along mold, is fabricate conventional PDMS. This overcomes problems associated promising material high‐performance microdevices.
Язык: Английский
Процитировано
0
Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113076 - 113076
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Physics of Fluids, Год журнала: 2025, Номер 37(3)
Опубликована: Март 1, 2025
Inertial microfluidic technology has emerged as a highly promising approach for the separation of particles/cells, characterized by high throughput and label-free features. This study presents novel inertial chip design that enables continuous target particles at low Reynolds numbers (Re ≤ 36). To enhance its sorting performance, influences = 3.7–60), particle sizes (d 10 20 μm), outlet flow rates on efficiency purity are further examined, phase diagram optimal working conditions is obtained. The evolution field structure within comprehensively analyzed, which can be divided into three distinct regions, namely, main flow, sheath vortex. mechanism migration behavior across curved streamlines explored. device achieve maximum 94% large with fivefold increase in enrichment concentration, 31.3-fold purity, removal small reaching 97.1%. results demonstrate this facilitate direct larger based their size, presenting numerous advantages, such short microchannel length, number, minimal cell damage, ease operation. Hence, method represents an easy-to-use straightforward techniques anticipated to have practical application rare circulating tumor cells from complex solutions.
Язык: Английский
Процитировано
0