Frontiers in Lab on a Chip Technologies,
Journal Year:
2024,
Volume and Issue:
3
Published: May 13, 2024
Microfluidic
devices
are
useful
tools
for
a
wide
range
of
biomedical,
industrial,
and
environmental
applications.
Hybrid
microfluidic
utilising
more
than
two
materials
increasingly
being
used
their
capacity
to
produce
unique
structures
perform
novel
functions.
However,
an
analysis
publications
across
the
field
shows
that
whilst
hybrid
have
been
reported,
there
remains
no
system
classifying
which
could
help
future
researchers
in
optimising
material
selection.
To
resolve
this
issue,
we
propose
primarily
as
containing
either
structural,
chemical,
or
electrical
components.
This
is
expanded
upon
developed
into
hierarchy,
with
combinations
different
primary
components
categorised
secondary
tertiary
device
groupings.
classification
approach
it
describes
can
be
combined
create
devices.
Drug Discovery Today,
Journal Year:
2024,
Volume and Issue:
29(4), P. 103936 - 103936
Published: Feb. 29, 2024
This
review
highlights
the
transformative
impact
of
microfluidic
technology
on
personalized
drug
delivery.
Microfluidics
addresses
issues
in
traditional
synthesis,
providing
precise
control
and
scalability
nanoparticle
fabrication,
platforms
show
high
potential
for
versatility,
offering
patient-specific
dosing
real-time
monitoring
capabilities,
all
integrated
into
wearable
technology.
Covalent
conjugation
antibodies
to
nanoparticles
improves
bioactivity,
driving
innovations
targeting.
The
integration
microfluidics
with
sensor
technologies
artificial
intelligence
facilitates
feedback
autonomous
adaptation
delivery
systems.
Key
challenges,
such
as
droplet
polydispersity
fluidic
handling,
along
future
directions
focusing
reliability,
are
essential
considerations
advancing
Frontiers in Lab on a Chip Technologies,
Journal Year:
2025,
Volume and Issue:
4
Published: Jan. 28, 2025
Microfluidic
systems,
especially
those
using
capillary
forces,
have
recently
attracted
considerable
interest
due
to
their
potential
facilitate
passive
fluid
management
in
portable
diagnostic
devices
and
point-of-care
settings.
These
systems
utilize
forces
autonomously
regulate
flow,
eliminating
the
requirement
for
external
power
providing
a
more
straightforward
economical
option
compared
active
microfluidic
systems.
This
review
examines
fundamental
concepts
of
capillary-driven
microfluidics,
emphasizing
significant
progress
design
pumps
valves,
as
well
influence
surface
tension,
wettability,
geometrical
configurations
microchannels
on
enhancement
dynamics.
Furthermore,
explores
other
configurations,
such
porous
solid
substrates,
illustrate
healthcare
biochemical
applications.
Moreover,
challenges
related
managing
flow
rates
enhancing
reproducibility
are
addressed,
alongside
recent
innovations
designed
overcome
these
challenges.
Capillary
offer
an
effective
reliable
foundation
developing
miniaturized
instruments,
which
hold
across
various
domains,
including
biological
research
environmental
monitoring.
Biosensors,
Journal Year:
2025,
Volume and Issue:
15(4), P. 222 - 222
Published: March 31, 2025
The
growing
demand
for
real-time,
non-invasive,
and
cost-effective
health
monitoring
has
driven
significant
advancements
in
portable
point-of-care
testing
(POCT)
devices.
Among
these,
optical
biosensors
have
emerged
as
promising
tools
the
detection
of
critical
biomarkers
such
uric
acid
(UA)
blood
glucose.
Different
transduction
methods,
like
fluorescence,
surface
plasmon
resonance
(SPR),
colorimetric
approaches,
are
talked
about,
with
a
focus
on
how
sensitive,
specific,
they
are.
Despite
considerable
advancements,
several
challenges
persist,
including
sensor
stability,
miniaturization,
interference
effects,
need
calibration-free
operation.
This
review
also
explores
issues
related
to
cost-effectiveness,
data
integration,
wireless
connectivity
remote
monitoring.
further
examines
regulatory
considerations
commercialization
aspects
biosensors,
addressing
gap
between
research
developments
clinical
implementation.
Future
perspectives
emphasize
integration
artificial
intelligence
(AI)
healthcare
improved
diagnostics,
alongside
development
wearable
implantable
continuous
Innovative
potential
change
way
people
manage
their
by
quickly
accurately
measuring
glucose
levels.
is
especially
true
decentralized
solutions
grows.
By
critically
evaluating
existing
work
exploring
limitations
opportunities
field,
this
will
help
guide
more
efficient,
accessible,
reliable
POCT
devices
that
can
improve
patient
outcomes
quality
life.
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(1)
Published: Jan. 1, 2025
ABSTRACT
Silicone
rubbers,
such
as
polydimethylsiloxane
(PDMS),
have
been
widely
used
in
biotechnology
and
medical
science
because
of
their
excellent
properties.
However,
microfabrication
silicone
rubbers
remains
to
be
problematic
the
high
viscosity
adhesiveness
(tackiness)
rubber,
making
it
difficult
fill
molds
reproduce
shapes
during
soft
lithography.
Also,
patterns
made
rubber
are
prone
pattern
collapse.
To
address
these,
we
designed
molecules
that
can
modified
by
radiation
whose
hardness
adjusted
after
microfabrication.
By
combining
materials
with
different
chemical
structures
molecular
weights,
developed
a
low
suitable
for
modification.
The
synthesized
had
filling
ability
micropatterned
adhesiveness,
which
prevented
Moreover,
elastic
modulus
controlled
using
high‐energy
electron
beam
(EB)
irradiation.
radiation‐modified
sheet
retained
its
transparency
visible
light,
oxygen
permeability,
drug
adsorption
adhesion.
utilizing
these
characteristics,
new
technique
was
produces
microfabricated
hydrophilicity
imprinting
technology
followed
EB
Soft
lithography
then
performed
on
transfer
micropillar
structure.
Pillar
were
accurately
fabricated
diameter
1.0
μm
or
less
along
mold,
is
fabricate
conventional
PDMS.
This
overcomes
problems
associated
promising
material
high‐performance
microdevices.
Physics of Fluids,
Journal Year:
2025,
Volume and Issue:
37(3)
Published: March 1, 2025
Inertial
microfluidic
technology
has
emerged
as
a
highly
promising
approach
for
the
separation
of
particles/cells,
characterized
by
high
throughput
and
label-free
features.
This
study
presents
novel
inertial
chip
design
that
enables
continuous
target
particles
at
low
Reynolds
numbers
(Re
≤
36).
To
enhance
its
sorting
performance,
influences
=
3.7–60),
particle
sizes
(d
10
20
μm),
outlet
flow
rates
on
efficiency
purity
are
further
examined,
phase
diagram
optimal
working
conditions
is
obtained.
The
evolution
field
structure
within
comprehensively
analyzed,
which
can
be
divided
into
three
distinct
regions,
namely,
main
flow,
sheath
vortex.
mechanism
migration
behavior
across
curved
streamlines
explored.
device
achieve
maximum
94%
large
with
fivefold
increase
in
enrichment
concentration,
31.3-fold
purity,
removal
small
reaching
97.1%.
results
demonstrate
this
facilitate
direct
larger
based
their
size,
presenting
numerous
advantages,
such
short
microchannel
length,
number,
minimal
cell
damage,
ease
operation.
Hence,
method
represents
an
easy-to-use
straightforward
techniques
anticipated
to
have
practical
application
rare
circulating
tumor
cells
from
complex
solutions.
Micromachines,
Journal Year:
2025,
Volume and Issue:
16(4), P. 385 - 385
Published: March 28, 2025
Microfluidic
technology
is
an
emerging
interdisciplinary
field
that
uses
micropipes
to
handle
or
manipulate
tiny
fluids
in
chemistry,
fluid
physics,
and
biomedical
engineering.
As
one
of
the
rapid
prototyping
methods,
three-dimensional
(3D)
printing
technique,
which
cost-effective
has
integrated
molding
characteristics,
become
important
manufacturing
for
microfluidic
chips.
Polymethyl-methacrylate
(PMMA),
as
exceptional
thermoplastic
material,
found
widespread
application
microfluidics.
This
paper
presents
a
comprehensive
process
study
on
fabrication
fused
deposition
modeling
(FDM)
3D-printed
PMMA
chips
(chips),
encompassing
finite
element
numerical
analysis
studies,
orthogonal
parameter
optimization
experiments,
reactors
reaction
between
copper
ions
ammonium
hydroxide.
In
this
work,
thermal
stress
model
shows
platform
temperature
was
significant
prevent
warping
delamination
3D
process.
A
single
technique
employed
fabricate
with
square
cross-sectional
dimensions
reduced
200
μm,
microchannels
exhibited
no
clogging
leakage.
The
experimental
method
carried
out,
optimized
resulted
reduction
microchannel
profile
Ra
1.077
μm.
Finally,
set
chemical
experiments
hydroxide
are
performed
microreactor.
Furthermore,
color
data
graph
obtained.
provides
cheap
high-quality
research
future
water
quality
detection
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
The
existence
of
massive
amounts
red
blood
cells
(RBCs)
and
other
cell
components
poses
a
challenge
for
the
efficient
extraction
white
(WBCs)
from
blood.
Herein,
we
proposed
modular
inertial
microfluidics
WBCs
lysed
samples.
different
WBC
needs
could
be
met
by
flexibly
combining
washing
module
concentration
in
microfluidics.
First,
respective
optimal
flow
rates
modules
with
channel
sizes
were
explored.
Then,
based
on
combination
modules,
three
modes
to
meet
processing
large-volume
sample,
low
volume
expansion,
easy
operation.
replacement
efficiency
recovery
rate
target
particles
all
greater
than
93%.
Finally,
samples
was
tested.
combined
use
Modes
1
2
achieved
93.1%
93.6%,
while
single
Mode
3
97.1%
95.9%.
Compared
traditional
centrifuges,
our
showed
better
performance
reduced
residual
RBC
fragments.
More
importantly,
it
provided
an
excellent
free
capability
needs.
