Mechanical forces and enzymatic digestion act together to induce the remodeling of collagen fibrils in tumor microenvironment
Lab on a Chip,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
microfluidic
chip-based
collagen
fibril
tissue
model
was
established
to
investigate
the
formation
of
orientation
fibrils
in
a
tumor
micro-environment.
Язык: Английский
Engineered Biomaterials and Model Systems to Study YAP/TAZ in Cancer
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(9), С. 5550 - 5561
Опубликована: Авг. 27, 2024
The
transcriptional
coactivators
yes-associated
protein
(YAP)
and
coactivator
with
PDZ-binding
motif
(TAZ)
are
master
regulators
involved
in
a
multitude
of
cancer
types
wide
range
tumorigenic
events,
including
stem
cell
renewal,
invasion,
metastasis,
tumor
precursor
emergence,
drug
resistance.
YAP/TAZ
known
to
be
regulated
by
several
external
cues
stimuli,
such
as
extracellular
matrix
stiffness,
spreading,
geometry,
shear
stress.
Therefore,
there
is
need
the
field
research
develop
design
relevant
Язык: Английский
Improving tumor microenvironment assessment in chip systems through next-generation technology integration
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Сен. 25, 2024
The
tumor
microenvironment
(TME)
comprises
a
diverse
array
of
cells,
both
cancerous
and
non-cancerous,
including
stromal
cells
immune
cells.
Complex
interactions
among
these
play
central
role
in
driving
cancer
progression,
impacting
critical
aspects
such
as
initiation,
growth,
invasion,
response
to
therapy,
the
development
drug
resistance.
While
targeting
TME
has
emerged
promising
therapeutic
strategy,
there
is
need
for
innovative
approaches
that
accurately
replicate
its
complex
cellular
non-cellular
interactions;
goal
being
develop
targeted,
personalized
therapies
can
effectively
elicit
anti-cancer
responses
patients.
Microfluidic
systems
present
notable
advantages
over
conventional
Язык: Английский