Human kidney organoids for modeling the development of different diseases
Current topics in developmental biology/Current Topics in Developmental Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Advances in cardiac organoid research: implications for cardiovascular disease treatment
Ziteng Huang,
Keran Jia,
Yadan Tan
и другие.
Cardiovascular Diabetology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 18, 2025
Globally,
cardiovascular
diseases
remain
among
the
leading
causes
of
mortality,
highlighting
urgent
need
for
innovative
research
models.
Consequently,
development
accurate
models
that
simulate
cardiac
function
holds
significant
scientific
and
clinical
value
both
disease
therapeutic
interventions.
Cardiac
organoids,
which
are
three-dimensional
structures
derived
from
induced
differentiation
stem
cells,
particularly
promising.
These
organoids
not
only
replicate
autonomous
beating
essential
electrophysiological
properties
heart
but
also
widely
employed
in
studies
related
to
diseases,
drug
efficacy
testing,
regenerative
medicine.
This
review
comprehensively
surveys
various
fabrication
techniques
used
create
their
diverse
applications
modeling
a
range
diseases.
We
emphasize
role
advanced
technologies
enhancing
maturation
functionality
ensuring
these
closely
resemble
native
tissue.
Furthermore,
we
discuss
monitoring
evaluation
parameters
critical
assessing
performance
considering
complex
interactions
within
multi-organ
systems.
approach
is
vital
precision
efficiency
development,
allowing
more
effective
strategies.
Ultimately,
this
aims
provide
thorough
perspective
on
fundamental
treatment
offering
insights
could
pave
way
future
advancements
understanding
addressing
prevalent
health
challenges.
Язык: Английский
Advances in humanoid organoid-based research on inter-organ communications during cardiac organogenesis and cardiovascular diseases
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 28, 2025
The
intimate
correlation
between
cardiovascular
diseases
and
other
organ
pathologies,
such
as
metabolic
kidney
diseases,
underscores
the
intricate
interactions
among
these
organs.
Understanding
inter-organ
communications
is
crucial
for
developing
more
precise
drugs
effective
treatments
systemic
diseases.
While
animal
models
have
traditionally
been
pivotal
in
studying
interactions,
human-induced
pluripotent
stem
cells
(hiPSCs)
offer
distinct
advantages
when
constructing
vitro
models.
Beyond
conventional
two-dimensional
co-culture
model,
hiPSC-derived
humanoid
organoids
emerged
a
substantial
advancement,
capable
of
replicating
essential
structural
functional
attributes
internal
organs
vitro.
This
breakthrough
has
spurred
development
multilineage
organoids,
assembloids,
organoids-on-a-chip
technologies,
which
allow
enhanced
physiological
relevance.
These
technologies
shown
great
potential
mimicking
coordinated
organogenesis,
exploring
disease
pathogenesis,
facilitating
drug
discovery.
As
central
system,
heart
serves
focal
point
an
extensively
studied
network
interactions.
review
focuses
on
advancements
challenges
organs,
presenting
comprehensive
exploration
this
cutting-edge
approach
research.
Язык: Английский
Advancements in Research on Genetic Kidney Diseases Using Human-Induced Pluripotent Stem Cell-Derived Kidney Organoids
Cells,
Год журнала:
2024,
Номер
13(14), С. 1190 - 1190
Опубликована: Июль 13, 2024
Genetic
or
hereditary
kidney
disease
stands
as
a
pivotal
cause
of
chronic
(CKD).
The
proliferation
and
widespread
utilization
DNA
testing
in
clinical
settings
have
notably
eased
the
diagnosis
genetic
diseases,
which
were
once
elusive
but
are
now
increasingly
identified
cases
previously
deemed
CKD
unknown
etiology.
However,
despite
these
diagnostic
strides,
research
into
pathogenesis
novel
drug
development
faces
significant
hurdles,
chiefly
due
to
dearth
appropriate
animal
models
challenges
posed
by
limited
patient
cohorts
studies.
Conversely,
advent
human-induced
pluripotent
stem
cells
(hiPSCs)
offer
promising
avenue
for
research.
Particularly,
hiPSC-derived
organoid
systems
presents
platform
investigating
various
forms
diseases.
Moreover,
integration
CRISPR/Cas9
technique
this
system
holds
immense
potential
efficient
on
This
review
aims
explore
applications
vitro
organoids
generated
from
hiPSCs
study
diverse
Additionally,
it
will
delve
limitations
outline
future
perspectives
advancing
crucial
area.
Язык: Английский
hPSCs-derived brain organoids for disease modeling, toxicity testing and drug evaluation
Experimental Neurology,
Год журнала:
2024,
Номер
385, С. 115110 - 115110
Опубликована: Дек. 10, 2024
Язык: Английский
人源类器官表型组学的研究进展及展望
Scientia Sinica Vitae,
Год журнала:
2024,
Номер
54(11), С. 2125 - 2142
Опубликована: Июль 24, 2024
Synthetic Biology and AI
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 265 - 290
Опубликована: Дек. 17, 2024
Synthetic
biology
and
artificial
intelligence
are
ushering
in
a
new
era
of
healthcare.
In
the
specific
context
bioengineering,
organoids,
brain-computer
interfaces,
ethical
considerations
particularly
salient.
Challenges
such
as
data
inadequacy,
unintended
bias
can
undermine
reliability
fairness
decision
making.
Additionally,
cultural
barriers
concerns
related
to
nonmaleficence,
autonomy,
justice
must
be
carefully
considered.
To
fully
realize
benefits
this
technological
synergy,
multidisciplinary
approach
is
necessary,
involving
scientists,
engineers,
ethicists,
policymakers.
Transparent
accountable
AI
systems
essential
mitigate
biases,
protect
privacy,
avoid
consequences.
By
proactively
addressing
developing
robust
regulatory
frameworks,
we
harness
power
these
technologies
for
betterment
humanity.
Язык: Английский