The ecology of the microbiome: Networks, competition, and stability

Science, Год журнала: 2015, Номер 350(6261), С. 663 - 666

Опубликована: Ноя. 5, 2015

What makes the gut microbiome stable? Classically, we think of our as stable, benign, and cooperative. Recent experimental work is beginning to unpick essential functions that can be attributed stable microbiota humans. To able manipulate improve health, need understand community structure composition models quantify predict stability. Coyte et al. applied concepts tools from ecology assembly. Independently developed converged on a surprising answer: A high diversity species likely coexist stably when system dominated by competitive, rather than cooperative, interactions. Science , this issue p. 663

Язык: Английский

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Spatial structure, cooperation and competition in biofilms

Nature Reviews Microbiology, Год журнала: 2016, Номер 14(9), С. 589 - 600

Опубликована: Июль 25, 2016

Язык: Английский

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Bacterial siderophores in community and host interactions

Nature Reviews Microbiology, Год журнала: 2019, Номер 18(3), С. 152 - 163

Опубликована: Ноя. 20, 2019

Язык: Английский

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The evolution of cooperation within the gut microbiota

Nature, Год журнала: 2016, Номер 533(7602), С. 255 - 259

Опубликована: Апрель 22, 2016

Язык: Английский

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Tumorigenesis: it takes a village

Nature reviews. Cancer, Год журнала: 2015, Номер 15(8), С. 473 - 483

Опубликована: Июль 2, 2015

Язык: Английский

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Metabolic co-dependence gives rise to collective oscillations within biofilms

Nature, Год журнала: 2015, Номер 523(7562), С. 550 - 554

Опубликована: Июль 1, 2015

Язык: Английский

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Ecology and evolution of metabolic cross-feeding interactions in bacteria

Natural Product Reports, Год журнала: 2018, Номер 35(5), С. 455 - 488

Опубликована: Янв. 1, 2018

The causes and consequences of bacterial metabolic cross-feeding mutualisms.

Язык: Английский

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Microbial nutrient niches in the gut

Environmental Microbiology, Год журнала: 2016, Номер 19(4), С. 1366 - 1378

Опубликована: Дек. 30, 2016

Summary The composition and function of the mammalian gut microbiota has been subject much research in recent years, but principles underlying assembly structure this complex community remain incompletely understood. Processes that shape are thought to be mostly niche‐driven, with environmental factors such as available nutrients largely determining whether or not an organism can establish. concept nutrient landscape dictates which organisms successfully colonize persist was first proposed Rolf Freter's niche theory. In a situation where perfectly mixed there is balanced microbial growth, Freter postulated only survive if it able utilize one few limiting more efficiently than its competitors. Recent experimental work indicates, however, vary space time. We propose scenario, theory must expanded account for co‐existence microorganisms utilizing same distinct sites at different times, metabolic flexibility mixed‐substrate utilization common strategies survival face ever‐present fluctuations.

Язык: Английский

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Biofilm Formation As a Response to Ecological Competition

PLoS Biology, Год журнала: 2015, Номер 13(7), С. e1002191 - e1002191

Опубликована: Июль 9, 2015

Bacteria form dense surface-associated communities known as biofilms that are central to their persistence and how they affect us. Biofilm formation is commonly viewed a cooperative enterprise, where strains species work together for common goal. Here we explore an alternative model: biofilm response ecological competition. We co-cultured diverse collection of natural isolates the opportunistic pathogen Pseudomonas aeruginosa studied effect on formation. show strain mixing reliably increases compared unmixed conditions. Importantly, leads strong competition: one dominates largely excludes other from biofilm. Furthermore, pyocins, narrow-spectrum antibiotics made by P. strains, can stimulate increasing attachment cells. Side-by-side comparisons using microfluidic assays suggest increase in occurs due general cellular damage: comparable pyocins disrupt membranes commercial damage DNA, inhibit protein synthesis or transcription. Our data bacteria competition detected antibiotic stress. This inconsistent with idea sub-lethal concentrations signals coordinate microbial communities, often concluded. Instead, our consistent sensing low-levels used detect respond competing genotypes produce them.

Язык: Английский

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Superorganismality and caste differentiation as points of no return: how the major evolutionary transitions were lost in translation

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Год журнала: 2017, Номер 93(1), С. 28 - 54

Опубликована: Май 15, 2017

More than a century ago, William Morton Wheeler proposed that social insect colonies can be regarded as superorganisms when they have morphologically differentiated reproductive and nursing castes are analogous to the metazoan germ-line soma. Following rise of sociobiology in 1970s, Wheeler's insights were largely neglected, we left with multiple new superorganism concepts mutually inconsistent uninformative on how superorganismality originated. These difficulties traced broadened sociobiological concept eusociality, which denies physical queen-worker caste differentiation is universal hallmark superorganismal colonies. Unlike early evolutionary naturalists geneticists such Weismann, Huxley, Fisher Haldane, who set out explain acquisition an unmated worker caste, goal was understand evolution broad-brush convenience category covers most forms cooperative breeding. By lumping diverse spectrum systems into single category, drawing attention away from distinct quantifiable traits, tradition has impeded straightforward connections between inclusive fitness theory major transitions paradigm for understanding irreversible shifts higher organizational complexity. We evaluate history by these inconsistencies accumulated, develop common-cause approach origins all eukaryote hierarchical complexity, use Hamilton's rule argue directly comparable. show only original definition unambiguously linked context-dependent altruism unconditional permanently ants, corbiculate bees, vespine wasps termites. strictly monogamous parents necessary, albeit not sufficient condition superorganismality, single-zygote bottlenecking being necessary but convergent complex soma across multicellular eukaryotes. infer conflict reduction origin any transitions, conclude controversies over status primarily emanate arbitrarily defined itself.

Язык: Английский

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