Molecular Metabolism,
Год журнала:
2016,
Номер
5(8), С. 635 - 645
Опубликована: Июль 2, 2016
A
disturbed
day-night
rhythm
is
associated
with
metabolic
perturbations
that
can
lead
to
obesity
and
type
2
diabetes
mellitus
(T2DM).
In
skeletal
muscle,
a
reduced
oxidative
capacity
also
the
development
of
T2DM.
However,
whether
in
muscle
displays
humans
has
so
far
not
been
investigated.Lean,
healthy
subjects
were
enrolled
standardized
living
protocol
regular
meals,
physical
activity
sleep
reflect
our
everyday
lifestyle.
Mitochondrial
was
examined
biopsies
taken
at
five
time
points
within
24-hour
period.Core-body
temperature
lower
during
early
night,
confirming
normal
rhythm.
Skeletal
demonstrated
robust
rhythm,
significant
effect
ADP-stimulated
respiration
(state
3
MO,
state
MOG
MOGS,
p
<
0.05).
Respiration
lowest
1
PM
highest
11
MOGS:
80.6
±
4.0
vs.
95.8
4.7
pmol/mg/s).
Interestingly,
fluctuation
mitochondrial
function
observed
whole-body
energy
expenditure,
peak
expenditure
4
AM
(p
0.001).
addition,
we
demonstrate
rhythmicity
mRNA
expression
molecular
clock
genes
human
muscle.Our
results
suggest
biological
drives
rhythms
metabolism.
It
tempting
speculate
disruption
these
contribute
deterioration
health
circadian
misalignment.
Endocrine Reviews,
Год журнала:
2016,
Номер
37(3), С. 278 - 316
Опубликована: Май 9, 2016
The
steep
rise
of
type
2
diabetes
mellitus
(T2DM)
and
associated
complications
go
along
with
mounting
evidence
clinically
important
sex
gender
differences.
T2DM
is
more
frequently
diagnosed
at
lower
age
body
mass
index
in
men;
however,
the
most
prominent
risk
factor,
which
obesity,
common
women.
Generally,
large
sex-ratio
differences
across
countries
are
observed.
Diversities
biology,
culture,
lifestyle,
environment,
socioeconomic
status
impact
between
males
females
predisposition,
development,
clinical
presentation.
Genetic
effects
epigenetic
mechanisms,
nutritional
factors
sedentary
lifestyle
affect
differently
both
sexes.
Furthermore,
hormones
have
a
great
on
energy
metabolism,
composition,
vascular
function,
inflammatory
responses.
Thus,
endocrine
imbalances
relate
to
unfavorable
cardiometabolic
traits,
observable
women
androgen
excess
or
men
hypogonadism.
Both
biological
psychosocial
responsible
for
outcome.
Overall,
stress
appears
greater
rather
than
men.
In
addition,
increases
cardiovascular
risk,
myocardial
infarction,
stroke
mortality
men,
compared
nondiabetic
subjects.
However,
when
dialysis
therapy
initiated,
comparable
females.
Diabetes
attenuate
protective
effect
female
development
cardiac
diseases
nephropathy.
Endocrine
behavioral
involved
inequalities
More
research
regarding
sex-dimorphic
pathophysiological
mechanisms
its
could
contribute
personalized
care
future
would
thus
promote
awareness
terms
sex-
gender-specific
factors.
Endocrine Reviews,
Год журнала:
2016,
Номер
37(6), С. 584 - 608
Опубликована: Окт. 20, 2016
Abstract
Circadian
(∼24-hour)
timing
systems
pervade
all
kingdoms
of
life
and
temporally
optimize
behavior
physiology
in
humans.
Relatively
recent
changes
to
our
environments,
such
as
the
introduction
artificial
lighting,
can
disorganize
circadian
system,
from
level
molecular
clocks
that
regulate
cellular
activities
synchronization
between
daily
cycles
solar
day.
Sleep/wake
are
intertwined
with
global
trends
indicate
these,
too,
increasingly
subject
disruption.
A
large
proportion
world's
population
is
at
increased
risk
environmentally
driven
rhythm
sleep
disruption,
a
minority
individuals
also
genetically
predisposed
misalignment
disorders.
The
consequences
disruption
system
profound
include
myriad
metabolic
ramifications,
some
which
may
be
compounded
by
adverse
effects
on
dietary
choices.
If
not
addressed,
deleterious
will
continue
cause
widespread
health
problems;
therefore,
implementation
numerous
behavioral
pharmaceutical
interventions
help
restore
alignment
enhance
important.
Proceedings of the National Academy of Sciences,
Год журнала:
2016,
Номер
113(10)
Опубликована: Фев. 8, 2016
Significance
Shift
work
is
a
risk
factor
for
hypertension,
inflammation,
and
cardiovascular
disease,
even
after
controlling
traditional
factors.
workers
frequently
undergo
circadian
misalignment
(i.e.,
between
the
endogenous
system
24-h
environmental/behavioral
cycles).
This
has
been
proposed
to
explain,
in
part,
why
shift
disease.
However,
impact
of
per
se
on
blood
pressure
inflammatory
markers
poorly
understood.
We
show—under
highly
controlled
laboratory
conditions—that
short-term
increases
healthy
adults.
Our
findings
may
help
explain
disease
risk.
Nutrients,
Год журнала:
2019,
Номер
11(6), С. 1234 - 1234
Опубликована: Май 30, 2019
Time-restricted
feeding
(TRF)
is
a
form
of
intermittent
fasting
that
involves
having
longer
daily
period.
Preliminary
studies
report
TRF
improves
cardiometabolic
health
in
rodents
and
humans.
Here,
we
performed
the
first
study
to
determine
how
affects
gene
expression,
circulating
hormones,
diurnal
patterns
risk
factors
Eleven
overweight
adults
participated
4-day
randomized
crossover
where
they
ate
between
8
am
2
pm
(early
(eTRF))
(control
schedule).
Participants
underwent
continuous
glucose
monitoring,
blood
was
drawn
assess
factors,
expression
whole
cells.
Relative
control
schedule,
eTRF
decreased
mean
24-hour
levels
by
4
±
1
mg/dl
(p
=
0.0003)
glycemic
excursions
12
3
0.001).
In
morning
before
breakfast,
increased
ketones,
cholesterol,
stress
response
aging
SIRT1
autophagy
LC3A
(all
p
<
0.04),
while
evening,
it
tended
increase
brain-derived
neurotropic
factor
(BNDF;
0.10)
also
MTOR
0.007),
major
nutrient-sensing
protein
regulates
cell
growth.
altered
cortisol
several
circadian
clock
genes
0.05).
levels,
alters
lipid
metabolism
may
have
anti-aging
effects
