Frontiers in Endocrinology,
Год журнала:
2019,
Номер
10
Опубликована: Июль 17, 2019
Melatonin,
a
hormone
synthesized
by
both
the
pineal
gland
and
retina,
functions
as
an
important
modulator
of
number
physiological
functions.
In
addition
to
its
rather
well-established
roles
in
regulation
circadian
rhythms,
sleep,
reproduction,
melatonin
has
also
been
identified
regulator
glucose
metabolism.
Recent
genomic
studies
have
shown
that
disruption
receptors
signaling
may
contribute
pathogenesis
type
2
diabetes,
although
exact
mechanisms
underlying
action
remain
unclear.
Additionally,
large
animal
highlighted
role
for
metabolism
energy
balance.
This
review
summarizes
current
knowledge
on
associated
play
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Июль 6, 2022
The
centenary
of
insulin
discovery
represents
an
important
opportunity
to
transform
diabetes
from
a
fatal
diagnosis
into
medically
manageable
chronic
condition.
Insulin
is
key
peptide
hormone
and
mediates
the
systemic
glucose
metabolism
in
different
tissues.
resistance
(IR)
disordered
biological
response
for
stimulation
through
disruption
molecular
pathways
target
Acquired
conditions
genetic
factors
have
been
implicated
IR.
Recent
biochemical
studies
suggest
that
dysregulated
metabolic
mediators
released
by
adipose
tissue
including
adipokines,
cytokines,
chemokines,
excess
lipids
toxic
lipid
metabolites
promote
IR
other
associated
with
several
groups
abnormal
syndromes
include
obesity,
diabetes,
dysfunction-associated
fatty
liver
disease
(MAFLD),
cardiovascular
disease,
polycystic
ovary
syndrome
(PCOS),
abnormalities.
Although
no
medication
specifically
approved
treat
IR,
we
summarized
lifestyle
changes
pharmacological
medications
used
as
efficient
intervention
improve
sensitivity.
Ultimately,
systematic
discussion
complex
mechanism
will
help
identify
potential
new
targets
closely
Nutrients,
Год журнала:
2019,
Номер
11(4), С. 719 - 719
Опубликована: Март 28, 2019
The
influence
of
meal
frequency
and
timing
on
health
disease
has
been
a
topic
interest
for
many
years.
While
epidemiological
evidence
indicates
an
association
between
higher
frequencies
lower
risk,
experimental
trials
have
shown
conflicting
results.
Furthermore,
recent
prospective
research
demonstrated
significant
increase
in
risk
with
high
(≥6
meals/day)
as
compared
to
low
(1–2
meals/day).
Apart
from
we
also
consider
breakfast
consumption
the
distribution
daily
energy
intake,
caloric
restriction,
night-time
eating.
A
central
role
this
complex
scenario
is
played
by
fasting
period
length
two
meals.
physiological
underpinning
these
interconnected
variables
may
be
through
internal
circadian
clocks,
food
that
asynchronous
natural
rhythms
exert
adverse
effects
risk.
Additionally,
alterations
potential
macronutrient
intake.A
regular
pattern
including
consumption,
consuming
proportion
early
day,
reduced
(i.e.,
2–3
meals/day),
periods
provide
benefits
such
inflammation,
improved
rhythmicity,
increased
autophagy
stress
resistance,
modulation
gut
microbiota
Journal of Internal Medicine,
Год журнала:
2019,
Номер
286(2), С. 181 - 191
Опубликована: Май 13, 2019
Abstract
The
Metabolic
Syndrome
is
a
cluster
of
cardio‐metabolic
risk
factors
and
comorbidities
conveying
high
both
cardiovascular
disease
type
2
diabetes.
It
responsible
for
huge
socio‐economic
costs
with
its
resulting
morbidity
mortality
in
most
countries.
underlying
aetiology
this
clustering
has
been
the
subject
much
debate.
More
recently,
significant
interest
focussed
on
involvement
circadian
system,
major
regulator
almost
every
aspect
human
health
metabolism.
Circadian
now
implicated
several
chronic
diseases
including
diabetes
disease.
There
increasing
evidence
connecting
disturbances
rhythm
not
only
key
components
but
also
main
sleep
disturbances,
depression,
steatohepatitis
cognitive
dysfunction.
Based
this,
we
propose
that
disruption
may
be
an
important
aetiological
factor
suggest
it
renamed
‘Circadian
Syndrome’.
With
increased
recognition
Syndrome’,
medicine,
through
timing
exercise,
light
exposure,
food
consumption,
dispensing
medications
sleep,
likely
to
play
greater
role
maintenance
individual
population
future.
Frontiers in Physiology,
Год журнала:
2019,
Номер
10
Опубликована: Июнь 25, 2019
Circadian
rhythms
(CR)
are
a
series
of
endogenous
autonomous
oscillators
generated
by
the
molecular
circadian
clock
which
acting
on
coordinating
internal
time
with
external
environment
in
24-h
daily
cycle.
The
system
is
major
regulatory
factor
for
nearly
all
physiological
activities
and
its
disorder
has
severe
consequences
human
health.
CR
disruption
common
issue
modern
society,
researches
about
people
jet
lag
or
shift
works
have
revealed
that
can
cause
cognitive
impairment,
psychiatric
illness,
metabolic
syndrome,
dysplasia,
cancer.
In
this
review,
we
summarized
synchronizers
synchronization
methods
used
experimental
research,
introduced
monitoring
detection
methods.
Moreover,
evaluated
conventional
databases,
analyzed
experiments
characterized
underlying
causes
disorder.
Finally,
further
discussed
latest
developments
understanding
disruption,
how
it
may
be
relevant
to
health
disease.
Briefly,
review
aimed
synthesize
previous
studies
aid
future
CR-related
diseases.
Cardiovascular Research,
Год журнала:
2021,
Номер
118(14), С. 2880 - 2902
Опубликована: Сен. 30, 2021
Abstract
Non-communicable
diseases
(NCDs)
are
fatal
for
more
than
38
million
people
each
year
and
thus
the
main
contributors
to
global
burden
of
disease
accounting
70%
mortality.
The
majority
these
deaths
caused
by
cardiovascular
(CVD).
risk
NCDs
is
strongly
associated
with
exposure
environmental
stressors
such
as
pollutants
in
air,
noise
exposure,
artificial
light
at
night,
climate
change,
including
heat
extremes,
desert
storms,
wildfires.
In
addition
traditional
factors
CVD
diabetes,
arterial
hypertension,
smoking,
hypercholesterolaemia,
genetic
predisposition,
there
a
growing
body
evidence
showing
that
physicochemical
environment
contribute
significantly
high
NCD
numbers.
Furthermore,
urbanization
accumulation
intensification
stressors.
This
comprehensive
expert
review
will
summarize
epidemiology
pathophysiology
focus
on
NCDs.
We
also
discuss
solutions
mitigation
measures
lower
impact
CVD.
Frontiers in Nutrition,
Год журнала:
2020,
Номер
7
Опубликована: Апрель 17, 2020
The
molecular
circadian
clock
regulates
metabolic
processes
within
the
cell,
and
alignment
of
these
clocks
between
tissues
is
essential
for
maintenance
homeostasis.
possibility
misalignment
arises
from
differential
responsiveness
to
environmental
cues
that
synchronize
(zeitgebers).
Although
light
dominant
cue
master
suprachiasmatic
nucleus,
many
other
are
sensitive
feeding
fasting.
When
rhythms
behaviour
altered,
example
by
shift
work
or
constant
availability
highly
palatable
foods,
strong
feedback
sent
peripheral
clocks.
Varying
degrees
phase
can
cause
systemic
processes.
Moreover,
when
there
a
endogenous
in
physiology
inputs,
such
as
during
inactive
phase,
body's
ability
maintain
homeostasis
impaired.
loss
coordination
organism
environment,
well
internal
tissues,
produce
cardiometabolic
disease
consequence.
aim
this
review
synthesize
on
mechanisms
effects
misalignment.
timing
food
intake
highlighted
powerful
with
potential
destroy
restore
synchrony
metabolism.
Diabetologia,
Год журнала:
2021,
Номер
64(11), С. 2367 - 2377
Опубликована: Авг. 16, 2021
Sleep
disorders
are
linked
to
development
of
type
2
diabetes
and
increase
the
risk
developing
complications.
Treating
sleep
might
therefore
play
an
important
role
in
prevention
progression.
However,
detection
treatment
not
part
standardised
care
for
people
with
diabetes.
To
highlight
importance
diabetes,
we
provide
a
review
literature
on
prevalence
association
between
health
outcomes,
such
as
glycaemic
control,
microvascular
macrovascular
complications,
depression,
mortality
quality
life.
Additionally,
examine
extent
which
treating
improves
these
outcomes.
We
performed
search
PubMed
from
inception
until
January
2021,
using
terms
disorders,
prevalence,
Both
observational
experimental
studies
were
included
review.
found
that
insomnia
(39%
[95%
CI
34,
44]),
obstructive
apnoea
(55-86%)
restless
legs
syndrome
(8-45%)
more
prevalent
compared
general
population.
No
reported
rates
circadian
rhythm
sleep-wake
central
hypersomnolence
or
parasomnias.
several
cross-sectional
prospective
showed
negatively
affect
outcomes
at
least
one
domain,
especially
control.
For
example,
is
associated
increased
HbA
