The Journal of Experimental Medicine,
Год журнала:
2018,
Номер
216(2), С. 253 - 266
Опубликована: Дек. 26, 2018
Folate
metabolism
is
crucial
for
many
biochemical
processes,
including
purine
and
thymidine
monophosphate
(dTMP)
biosynthesis,
mitochondrial
protein
translation,
methionine
regeneration.
These
processes
in
turn
support
critical
cellular
functions
such
as
cell
proliferation,
respiration,
epigenetic
regulation.
Not
surprisingly,
abnormal
folate
has
been
causally
linked
with
a
myriad
of
diseases.
In
this
review,
we
provide
historical
perspective,
delve
into
chemistry
that
often
overlooked,
point
out
various
missing
links
underdeveloped
areas
future
exploration.
Experimental & Molecular Medicine,
Год журнала:
2020,
Номер
52(1), С. 15 - 30
Опубликована: Янв. 1, 2020
Abstract
Over
90
years
ago,
Otto
Warburg’s
seminal
discovery
of
aerobic
glycolysis
established
metabolic
reprogramming
as
one
the
first
distinguishing
characteristics
cancer
1
.
The
field
metabolism
subsequently
revealed
additional
alterations
in
by
focusing
on
central
carbon
metabolism,
including
citric
acid
cycle
and
pentose
phosphate
pathway.
Recent
reports
have,
however,
uncovered
substantial
non-carbon
contributions
to
cell
viability
growth.
Amino
acids,
nutrients
vital
survival
all
types,
experience
reprogrammed
cancer.
This
review
outlines
diverse
roles
amino
acids
within
tumor
microenvironment.
Beyond
their
role
biosynthesis,
they
serve
energy
sources
help
maintain
redox
balance.
In
addition,
derivatives
contribute
epigenetic
regulation
immune
responses
linked
tumorigenesis
metastasis.
Furthermore,
discussing
transporters
transaminases
that
mediate
uptake
synthesis,
we
identify
potential
liabilities
targets
for
therapeutic
intervention.
CA A Cancer Journal for Clinicians,
Год журнала:
2021,
Номер
71(4), С. 333 - 358
Опубликована: Май 13, 2021
Abstract
Cancer
has
myriad
effects
on
metabolism
that
include
both
rewiring
of
intracellular
to
enable
cancer
cells
proliferate
inappropriately
and
adapt
the
tumor
microenvironment,
changes
in
normal
tissue
metabolism.
With
recognition
fluorodeoxyglucose‐positron
emission
tomography
imaging
is
an
important
tool
for
management
many
cancers,
other
metabolites
biological
samples
have
been
spotlight
diagnosis,
monitoring,
therapy.
Metabolomics
global
analysis
small
molecule
like
‐omics
technologies
can
provide
critical
information
about
state
are
otherwise
not
apparent.
Here,
authors
review
how
therapies
interact
with
at
cellular
systemic
levels.
An
overview
metabolomics
provided
a
focus
currently
available
they
applied
clinical
translational
research
setting.
The
also
discuss
could
be
further
leveraged
future
improve
patients
cancer.
British Journal of Cancer,
Год журнала:
2017,
Номер
116(12), С. 1499 - 1504
Опубликована: Май 4, 2017
Cells
require
one-carbon
units
for
nucleotide
synthesis,
methylation
and
reductive
metabolism,
these
pathways
support
the
high
proliferative
rate
of
cancer
cells.
As
such,
anti-folates,
drugs
that
target
have
long
been
used
in
treatment
cancer.
Amino
acids,
such
as
serine
are
a
major
source,
cells
particularly
susceptible
to
deprivation
by
restriction
or
inhibition
de
novo
synthesis.
Recent
work
has
also
begun
decipher
specific
sub-cellular
compartments
important
metabolism
In
this
review
we
summarise
historical
understanding
cancer,
describe
recent
findings
regarding
generation
usage
explore
possible
future
therapeutics
could
exploit
dependency
on
metabolism.
The Journal of Cell Biology,
Год журнала:
2016,
Номер
214(3), С. 249 - 257
Опубликована: Июль 25, 2016
Serine
metabolism
is
frequently
dysregulated
in
cancers;
however,
the
benefit
that
this
confers
to
tumors
remains
controversial.
In
many
cases,
extracellular
serine
alone
sufficient
support
cancer
cell
proliferation,
whereas
some
cells
increase
synthesis
from
glucose
and
require
de
novo
even
presence
of
abundant
serine.
Recent
studies
cast
new
light
on
role
cancer,
suggesting
active
might
be
required
facilitate
amino
acid
transport,
nucleotide
synthesis,
folate
metabolism,
redox
homeostasis
a
manner
impacts
cancer.
