Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 9, 2022
In
aging
society,
osteoporotic
fractures
have
become
one
major
social
problem
threatening
the
health
of
elderly
population
in
China.
Compared
with
conventional
fractures,
low
bone
mass,
defect
and
retarded
healing
issues
lead
to
great
difficulties
treatment
rehabilitation.
Addressing
concerns
clinical
settings,
we
proposed
“three
one”
repair
strategy
focusing
on
anti-osteoporosis
therapies,
appropriate
grafting
fracture
accelerating.
We
summarize
misconceptions
strategies
for
management,
expecting
improvement
prognosis
outcomes
further
improve
therapeutic
effect
living
quality
patients.
Advanced Functional Materials,
Год журнала:
2020,
Номер
30(44)
Опубликована: Фев. 19, 2020
Abstract
Bone
is
a
hard
yet
dynamic
tissue
with
remarkable
healing
capacities.
Research
to
date
has
greatly
advanced
the
understanding
of
how
bone
heals
and
led
marked
success
in
treatment
injuries.
Nevertheless,
effective
nonunions
large
defects
continues
present
challenge
for
orthopedic
surgeons.
Biomaterials
provide
researchers
powerful
instrument
potentially
guide
regeneration
challenging
environments.
However,
most
appropriate
biomaterial
engineering
be
an
area
intense
debate.
Indeed,
mechanical
properties
real
can
reproduced
vitro
but
development
functional
substitute
goes
beyond
sole
properties.
The
faithful
reproduction
as
organ
requires
combination
different
cell
types
temporal
regulation
molecular
signaling
involved
during
stages
formation
regeneration.
This
not
at
all
trivial
task.
Herein,
critical
aspects
healing/regeneration
including
loading,
inflammation,
vascularization,
innervation
are
described.
challenges
behind
biomaterials,
technologies
used
functionalize
them,
order
support
underlying
cellular
mechanisms
also
highlighted.
Journal of Clinical Investigation,
Год журнала:
2019,
Номер
129(12), С. 5137 - 5150
Опубликована: Окт. 21, 2019
Bone
is
richly
innervated
by
nerve
growth
factor–responsive
(NGF-responsive)
tropomyosin
receptor
kinase
A–expressing
(TrKa-expressing)
sensory
fibers,
which
are
required
for
osteochondral
progenitor
expansion
during
mammalian
skeletal
development.
Aside
from
pain
sensation,
little
known
regarding
the
role
of
innervation
in
bone
repair.
Here,
we
characterized
reinnervation
tissue
following
experimental
ulnar
stress
fracture
and
assessed
impact
loss
TrkA
signaling
this
process.
Sequential
histological
data
obtained
reporter
mice
subjected
to
demonstrated
a
marked
upregulation
NGF
expression
periosteal
stromal
progenitors
fracture-associated
macrophages.
Sprouting
arborization
CGRP+TrkA+
fibers
within
reactive
periosteum
NGF-enriched
cellular
domains
were
evident
at
time
points
preceding
vascularization,
ossification,
mineralization.
Temporal
inhibition
catalytic
activity
administration
1NMPP1
TrkAF592A
significantly
reduced
numbers
blunted
revascularization,
delayed
ossification
callus.
We
observed
similar
deficiencies
regrowth
healing
mouse
model
peripheral
neuropathy
induced
paclitaxel
treatment.
Together,
our
studies
demonstrate
an
essential
repair
implicate
nerves
as
important
upstream
mediator
Physiological Reviews,
Год журнала:
2018,
Номер
98(3), С. 1083 - 1112
Опубликована: Май 2, 2018
It
is
from
the
discovery
of
leptin
and
central
nervous
system
as
a
regulator
bone
remodeling
that
presence
autonomic
nerves
within
skeleton
transitioned
mere
histological
observation
to
mechanism
whereby
neurons
communicate
with
cells
microenvironment
regulate
homeostasis.
This
shift
in
paradigm
sparked
new
preclinical
clinical
investigations
aimed
at
defining
contribution
sympathetic,
parasympathetic,
sensory
process
development,
mass
accrual,
remodeling,
cancer
metastasis.
The
aim
this
article
review
data
led
current
understanding
interactions
between
skeletal
systems
present
critical
appraisal
literature,
bringing
forth
schema
can
put
into
physiological
context
main
genetic
pharmacological
observations
pointing
existence
an
control
different
types
found
skeleton,
their
functional
cells,
impact
on
accrual
possible
or
pathophysiological
relevance
these
findings
are
discussed.
Abstract
For
the
past
two
decades,
function
of
intrabony
nerves
on
bone
has
been
a
subject
intense
research,
while
is
still
hidden
in
corner.
In
present
review,
possible
crosstalk
between
and
peripheral
will
be
comprehensively
analyzed.
Peripheral
participate
development
repair
via
host
signals
generated
through
secretion
neurotransmitters,
neuropeptides,
axon
guidance
factors
neurotrophins,
with
additional
contribution
from
nerve‐resident
cells.
return,
contributes
to
this
microenvironmental
rendezvous
by
housing
within
its
internal
milieu
provide
mechanical
support
protective
shelf.
A
large
ensemble
chemical,
mechanical,
electrical
cues
works
harmony
marrow
stromal
cells
regulation
nerves.
The
not
limited
physiological
state,
but
also
involved
various
diseases
including
osteoporosis,
osteoarthritis,
heterotopic
ossification,
psychological
stress‐related
abnormalities,
related
tumors.
This
may
harnessed
design
tissue
engineering
scaffolds
for
defects
or
targeted
treatment
Abstract
The
initiation
of
osteogenesis
primarily
occurs
as
mesenchymal
stem
cells
undergo
differentiation
into
osteoblasts.
This
process
plays
a
crucial
role
in
bone
formation
and
homeostasis
is
regulated
by
two
intricate
processes:
cell
signal
transduction
transcriptional
gene
expression.
Various
essential
signaling
pathways,
including
Wnt,
BMP,
TGF-β,
Hedgehog,
PTH,
FGF,
Ephrin,
Notch,
Hippo,
Piezo1/2,
play
critical
facilitating
osteoblast
differentiation,
formation,
homeostasis.
Key
factors
this
include
Runx2,
Cbfβ,
Runx1,
Osterix,
ATF4,
SATB2,
TAZ/YAP.
Furthermore,
diverse
array
epigenetic
also
roles
at
the
level.
review
provides
an
overview
latest
developments
current
comprehension
concerning
pathways
signaling,
regulation
hormones,
genes
involved
commitment
lineage,
well
maintenance
paper
reviews
via
mechanisms,
such
histone
DNA
modifications.
Additionally,
we
summarize
biology
spurred
recent
advancements
various
modern
technologies
bioinformatics.
By
synthesizing
these
insights
comprehensive
understanding
further
clarification
mechanisms
underlying
lineage
commitment,
highlights
potential
new
therapeutic
applications
for
treatment
diseases.
Experimental & Molecular Medicine,
Год журнала:
2022,
Номер
54(11), С. 1844 - 1849
Опубликована: Ноя. 29, 2022
Abstract
The
mammalian
skeletal
system
is
densely
innervated
by
both
neural
and
vascular
networks.
Peripheral
nerves
in
the
skeleton
include
sensory
sympathetic
nerves.
crosstalk
between
tissues
critical
for
development
regeneration.
cellular
processes
of
osteogenesis
angiogenesis
are
coupled
physiological
pathophysiological
contexts.
molecular
regulation
have
yet
to
be
fully
defined.
This
review
will
provide
a
detailed
characterization
regulatory
role
blood
vessels
during
bone
Furthermore,
given
importance
spatial
relationship
bone,
we
discuss
neurovascular
coupling
pathological
formation.
A
better
understanding
interactions
inform
future
novel
therapeutic
targeting
clinical
repair
