Magnetic cilia carpets with programmable metachronal waves

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Май 26, 2020

Abstract Metachronal waves commonly exist in natural cilia carpets. These emergent phenomena, which originate from phase differences between neighbouring self-beating cilia, are essential for biological transport processes including locomotion, liquid pumping, feeding, and cell delivery. However, studies of such complex active systems limited, particularly the experimental side. Here we report magnetically actuated, soft, artificial By stretching folding onto curved templates, programmable magnetization patterns can be encoded into carpets, exhibit metachronal dynamic magnetic fields. We have tested both capabilities a fluid environment locomotion on solid surface. This robotic system provides highly customizable platform that not only assists understanding fundamental rules but also paves path to cilia-inspired soft robots future biomedical applications.

Язык: Английский

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The multiscale physics of cilia and flagella

Nature Reviews Physics, Год журнала: 2020, Номер 2(2), С. 74 - 88

Опубликована: Янв. 3, 2020

Язык: Английский

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Dynamics of Flexible Fibers in Viscous Flows and Fluids

Annual Review of Fluid Mechanics, Год журнала: 2019, Номер 51(1), С. 539 - 572

Опубликована: Янв. 5, 2019

The dynamics and deformations of immersed flexible fibers are at the heart important industrial biological processes, induce peculiar mechanical transport properties in fluids that contain them, basis for novel methods flow control. Here we focus on low Reynolds number regime where advances studying these fiber-fluid systems have been especially rapid. On experimental side this is due to new fiber synthesis, microfluidic control, microscope based tracking measurement techniques. Likewise, there continuous improvements specialized mathematical modeling numerical needed capture interactions slender with flows, boundaries, each other.

Язык: Английский

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A lasting symbiosis: how the Hawaiian bobtail squid finds and keeps its bioluminescent bacterial partner

Nature Reviews Microbiology, Год журнала: 2021, Номер 19(10), С. 666 - 679

Опубликована: Июнь 4, 2021

Язык: Английский

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Links between metamorphosis and symbiosis in holometabolous insects

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2019, Номер 374(1783), С. 20190068 - 20190068

Опубликована: Авг. 23, 2019

Many animals depend on microbial symbionts to provide nutrition, defence or other services. Holometabolous insects, as well that undergo metamorphosis, face unique constraints symbiont maintenance. Microbes present in larvae encounter a radical transformation of their habitat and may also need withstand chemical immunological challenges. Metamorphosis provides an opportunity, symbiotic associations can be decoupled over development. For example, some holometabolous insects maintain the same adults, but house it different tissues; species, adults harbour entirely types numbers microbes, accordance with shifts host diet habitat. Such flexibility advantage hemimetabolous which selection adult-stage constrained by its negative effects immature stages, vice versa. Additionally, metamorphosis itself directly influenced symbionts. Across disparate insect taxa, microbes protect hosts from pathogen infection, supply nutrients essential for rebuilding adult body cues regulating pupation. However, remain completely unstudied many families even orders Holometabola, future research will undoubtedly reveal more links between microbiota, two widespread features animal life. This article is part theme issue ‘The evolution complete metamorphosis’.

Язык: Английский

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A lasting symbiosis: how Vibrio fischeri finds a squid partner and persists within its natural host

Nature Reviews Microbiology, Год журнала: 2021, Номер 19(10), С. 654 - 665

Опубликована: Июнь 4, 2021

Язык: Английский

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The effect of flow on swimming bacteria controls the initial colonization of curved surfaces

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Июнь 5, 2020

Abstract The colonization of surfaces by bacteria is a widespread phenomenon with consequences on environmental processes and human health. While much known about the molecular mechanisms surface colonization, influence physical environment remains poorly understood. Here we show that non-planar motile largely controlled flow. Using microfluidic experiments Pseudomonas aeruginosa Escherichia coli , demonstrate velocity gradients created curved drive preferential attachment to specific regions collecting surface, namely leeward side cylinders immediately downstream apexes corrugated surfaces, in stark contrast where nonmotile cells attach. Attachment location rate depend local hydrodynamics and, as revealed mathematical model benchmarked observations, cell morphology swimming traits. These results highlight importance flow magnitude bacterial surfaces.

Язык: Английский

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Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays

Nature Physics, Год журнала: 2020, Номер 16(9), С. 958 - 964

Опубликована: Июнь 8, 2020

Язык: Английский

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Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia

eLife, Год журнала: 2023, Номер 12

Опубликована: Янв. 26, 2023

Motile cilia are hair-like cell extensions that beat periodically to generate fluid flow along various epithelial tissues within the body. In dense multiciliated carpets, were shown exhibit a remarkable coordination of their in form traveling metachronal waves, phenomenon which supposedly enhances transport. Yet, how coordinate regular epithelia move fluids remains insufficiently understood, particularly due lack rigorous quantification. We combine experiments, novel analysis tools, and theory address this knowledge gap. To investigate collective dynamics cilia, we studied zebrafish nose brain. focused mainly on nose, its conserved properties with other ciliated superior accessibility for non-invasive imaging. revealed synchronized only locally size local synchronization domains increases viscosity surrounding medium. Even though is only, observed global patterns waves across epithelium. Intriguingly, these wave direction individual fish, but different left right noses, unveiling chiral asymmetry coordination. understand implications pumping, used computational model array cilia. found prevents steric collisions, i.e., colliding each other, improves pumping hardly affects flow. conclusion, show together tissue-scale alignment coincide epithelia, enhance physiological function pumping.

Язык: Английский

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Multiorifice acoustic microrobot for boundary-free multimodal 3D swimming

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(4)

Опубликована: Янв. 22, 2025

The emerging new generation of small-scaled acoustic microrobots is poised to expedite the adoption microrobotics in biomedical research. Recent designs these have enabled intricate bioinspired motions, paving way for their real-world applications. We present a multiorifice design air-filled spherical that convert wave energy efficient propulsion through resonant encapsulated microbubble. These can swim boundary-free three-dimensional (3D) space while switching between various frequency-dependent locomotion modes. explore dynamics with diameters ranging from 10 μm 100 μm, focusing on 3D swimming and multimodal response stimuli below 1 MHz. Further, we elucidate microrobots, featuring single cavity, which contributes complex streaming facilitates swift, unrestricted movements. Finally, demonstrate incorporating additional nickel gold layers significantly enhances steering visibility optoacoustic ultrasound imaging, enabling development next healthcare

Язык: Английский

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