Cell Reports,
Год журнала:
2022,
Номер
40(13), С. 111410 - 111410
Опубликована: Сен. 1, 2022
Microbial
communities
execute
metabolic
pathways
to
drive
global
nutrient
cycles.
Within
a
community,
functionally
specialized
strains
can
perform
different
yet
complementary
steps
within
linear
pathway,
phenomenon
termed
division
of
labor
(MDOL).
However,
little
is
known
about
how
such
behaviors
shape
microbial
communities.
Here,
we
derive
theoretical
framework
define
the
assembly
community
that
degrades
an
organic
compound
through
MDOL.
The
indicates
ensure
stability,
performing
initial
should
hold
growth
advantage
(m)
over
"private
benefit"
(n)
strain
last
step.
steady-state
frequency
then
determined
by
quotient
n
and
m.
Our
experiments
show
accurately
predicts
our
synthetic
consortia
degrade
naphthalene
results
provide
insights
for
designing
managing
stable
systems
pathway
optimization.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Апрель 19, 2022
Honeybees
are
highly
social
insects
with
a
rich
behavioral
repertoire
and
versatile
model
for
neurobiological
research.
Their
gut
microbiota
comprises
limited
number
of
host-restricted
bacterial
phylotypes
that
important
honeybee
health.
However,
it
remains
unclear
how
specific
members
affect
behaviors.
Here,
we
find
antibiotic
exposure
disturbs
the
community
influences
phenotypes
under
field
conditions.
Using
laboratory-generated
gnotobiotic
bees,
show
normal
is
required
olfactory
learning
memory
abilities.
Brain
transcriptomic
profiling
reveals
distinct
brain
gene
expression
patterns
between
microbiota-free
conventional
bees.
Subsequent
metabolomic
analyses
both
hemolymph
samples
mainly
regulates
tryptophan
metabolism.
Our
results
indicate
host-specific
Lactobacillus
strains
promote
behavior
by
transforming
to
indole
derivatives
activate
host
aryl
hydrocarbon
receptor.
findings
highlight
contributions
neurological
processes,
thus
providing
promising
understand
host-microbe
interactions.
Journal of Experimental Biology,
Год журнала:
2021,
Номер
224(2)
Опубликована: Янв. 15, 2021
ABSTRACT
Insects
are
the
most
diverse
group
of
animals
and
colonize
almost
all
environments
on
our
planet.
This
diversity
is
reflected
in
structure
function
microbial
communities
inhabiting
insect
digestive
system.
As
mammals,
gut
microbiota
insects
can
have
important
symbiotic
functions,
complementing
host
nutrition,
facilitating
dietary
breakdown
or
providing
protection
against
pathogens.
There
an
increasing
number
models
that
experimentally
tractable,
mechanistic
studies
microbiota–host
interactions.
In
this
Review,
we
will
summarize
recent
findings
advanced
understanding
molecular
mechanisms
underlying
symbiosis
between
their
microbiota.
We
open
article
with
a
general
introduction
to
then
turn
towards
discussion
particular
processes
governing
colonization
environment
as
well
beneficial
roles
mediated
by
The
Review
highlights
that,
although
active
field
research
implications
for
fundamental
applied
science,
still
early
stage
mechanisms.
However,
expanding
capability
culture
microbiomes
manipulate
microbe–host
interactions
promises
new
insights
from
symbioses.
Microbiology Spectrum,
Год журнала:
2022,
Номер
10(1)
Опубликована: Янв. 5, 2022
Honeybee
gut
microbiota
plays
an
important
role
in
host
physiology
and
metabolism.
Recent
studies
have
shown
that
the
influence
of
resident
microorganisms
regulation
honeybee
immune
system
is
profound,
which
protects
against
pathogen
Serratia
marcescens.
However,
only
few
core
members
functions
been
studied.
Here,
we
explored
how
different
bee
bacterial
species
aided
clearance
pathogenic
Hafnia
alvei,
causes
septicemia
with
a
high
mortality
rate.
We
found
both
Gilliamella
apicola
W8136
Lactobacillus
apis
W8172
protect
honeybees
from
opportunistic
pathogen,
while
two
other
strains
did
not
affect
invasion
H.
alvei.
Transcriptomic
analysis
revealed
induced
expression
profiles
gut.
Specifically,
regulator
genes
Toll
pathway,
PGRP-S3
recognizing
Gram-positive
Spätzle
bind
to
protein
for
downstream
signal
transduction,
were
elevated
by
L.
apis.
Correspondingly,
multiple
encoding
antibacterial
proteins
also
stimulated
Interestingly,
increased
apidaecin,
exhibited
vitro
inhibitory
effect
on
To
elucidate
difference
host's
regulation,
comparative
genomic
analyses
indicate
S-layer
unique
are
potentially
involved
signaling
activation
production.
IMPORTANCE
Honeybees
essential
pollinators
supporting
global
agricultural
economies
food
supplies.
decline
has
linked
several
factors,
infection
considered
one
most
significant
contributing
factors.
Although
limited
number
pathogens
identified,
alvei
causing
adult
bees.
In
this
study,
showed
members,
Lactobacillus,
can
clear
invasion.
Mono-colonization
specific
stimulate
pathway
AMPs.
apidaecin
upregulated
symbionts
more
effective
pathogen.
Moreover,
our
suggests
surface-layer
driver
signaling,
highlighting
variation
regulating
system.
Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2020,
Номер
375(1808), С. 20190602 - 20190602
Опубликована: Авг. 9, 2020
Across
the
tree
of
life,
hosts
have
evolved
mechanisms
to
control
and
mediate
interactions
with
symbiotic
partners.
We
suggest
that
evolution
physical
structures
allow
spatially
separate
symbionts,
termed
compartmentalization,
is
a
common
mechanism
used
by
hosts.
Such
compartmentalization
allows
to:
(i)
isolate
symbionts
their
reproduction;
(ii)
reward
cooperative
punish
or
stop
non-cooperative
symbionts;
(iii)
reduce
direct
conflict
among
different
strains
in
single
host.
Compartmentalization
has
allowed
increase
benefits
they
obtain
from
partners
across
diversity
interactions,
including
legumes
rhizobia,
plants
fungi,
squid
Vibrio
,
insects
nutrient
provisioning
bacteria,
insects,
human
microbiome.
In
cases
where
not
evolved,
we
ask
why
not.
argue
when
interact
competitive
hierarchy,
engage
partnerships
which
are
less
costly,
likely
evolve.
conclude
key
understanding
cooperation.
This
article
part
theme
issue
‘The
role
microbiome
host
evolution’.
